ID Q2UZM9_9TRYP Unreviewed; 184 AA.
AC Q2UZM9;
DT 24-JAN-2006, integrated into UniProtKB/TrEMBL.
DT 24-JAN-2006, sequence version 1.
DT 22-FEB-2023, entry version 79.
DE SubName: Full=Mono-cysteine glutaredoxin {ECO:0000313|EMBL:CAF02300.1};
GN Name=mgrx {ECO:0000313|EMBL:CAF02300.1};
OS Trypanosoma brucei.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=5691 {ECO:0000313|EMBL:CAF02300.1};
RN [1] {ECO:0000313|EMBL:CAF02300.1}
RP NUCLEOTIDE SEQUENCE.
RA Filser M.;
RT "Cloning and functional chracterization of a mono-cysteine glutaredoxin
RT from Trypanosoma brucei.";
RL Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CAF02300.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=17242409; DOI=10.1074/jbc.M608140200;
RA Melchers J., Dirdjaja N., Ruppert T., Krauth-Siegel R.L.;
RT "Glutathionylation of trypanosomal thiol redox proteins.";
RL J. Biol. Chem. 282:8678-8694(2007).
RN [3] {ECO:0007829|PDB:2LTK}
RP STRUCTURE BY NMR OF 76-184.
RX PubMed=23259530; DOI=10.1089/ars.2012.4859;
RA Manta B., Pavan C., Sturlese M., Medeiros A., Crispo M., Berndt C.,
RA Krauth-Siegel R.L., Bellanda M., Comini M.A.;
RT "Iron-sulfur cluster binding by mitochondrial monothiol glutaredoxin-1 of
RT Trypanosoma brucei: molecular basis of iron-sulfur cluster coordination and
RT relevance for parasite infectivity.";
RL Antioxid. Redox Signal. 19:665-682(2013).
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DR EMBL; AJ619696; CAF02300.1; -; Genomic_DNA.
DR PDB; 2LTK; NMR; -; A=76-184.
DR PDBsum; 2LTK; -.
DR AlphaFoldDB; Q2UZM9; -.
DR BMRB; Q2UZM9; -.
DR SMR; Q2UZM9; -.
DR VEuPathDB; TriTrypDB:Tb1125.9.3590; -.
DR VEuPathDB; TriTrypDB:Tb427_090021600; -.
DR VEuPathDB; TriTrypDB:Tb927.9.3590; -.
DR VEuPathDB; TriTrypDB:Tbg972.9.1840; -.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd03028; GRX_PICOT_like; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR002109; Glutaredoxin.
DR InterPro; IPR033658; GRX_PICOT-like.
DR InterPro; IPR004480; Monothiol_GRX-rel.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR10293; GLUTAREDOXIN FAMILY MEMBER; 1.
DR PANTHER; PTHR10293:SF70; GLUTAREDOXIN-LIKE PROTEIN; 1.
DR Pfam; PF00462; Glutaredoxin; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS51354; GLUTAREDOXIN_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:2LTK}; Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT DOMAIN 91..155
FT /note="Glutaredoxin"
FT /evidence="ECO:0000259|Pfam:PF00462"
SQ SEQUENCE 184 AA; 20431 MW; 882F6BA0E78905AA CRC64;
MRRLSGSTCL LTGVTRAGRW LPTTAPCLSL CSFFLTASRR KQSTSGIGGD VRDIEETHPD
FQPRLVSADL AEDEIAMVKK DIDDTIKSED VVTFIKGLPE APMCAYSKRM IDVLEALGLE
YTSFDVLAHP VVRSYVKEVS EWPTIPQLFI KAEFVGGLDI VTKMLESGDL KKMLRDKGIT
CRDL
//
