ID Q2V4S5_CAEEL Unreviewed; 420 AA.
AC Q2V4S5;
DT 10-JAN-2006, integrated into UniProtKB/TrEMBL.
DT 10-JAN-2006, sequence version 1.
DT 27-MAR-2024, entry version 125.
DE SubName: Full=G-protein coupled receptors family 1 profile domain-containing protein {ECO:0000313|EMBL:CCD64322.1};
GN Name=npr-16 {ECO:0000313|EMBL:CCD64322.1,
GN ECO:0000313|WormBase:F56B6.5b};
GN ORFNames=CELE_F56B6.5 {ECO:0000313|EMBL:CCD64322.1}, F56B6.5
GN {ECO:0000313|WormBase:F56B6.5b};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD64322.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD64322.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD64322.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR EMBL; BX284606; CCD64322.1; -; Genomic_DNA.
DR RefSeq; NP_001041259.1; NM_001047794.2.
DR AlphaFoldDB; Q2V4S5; -.
DR SMR; Q2V4S5; -.
DR EnsemblMetazoa; F56B6.5b.1; F56B6.5b.1; WBGene00006864.
DR GeneID; 180643; -.
DR UCSC; F56B6.5b; c. elegans.
DR AGR; WB:WBGene00006864; -.
DR WormBase; F56B6.5b; CE39375; WBGene00006864; npr-16.
DR GeneTree; ENSGT00940000157017; -.
DR HOGENOM; CLU_645979_0_0_1; -.
DR OrthoDB; 2874314at2759; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00006864; Expressed in larva and 3 other cell types or tissues.
DR ExpressionAtlas; Q2V4S5; baseline and differential.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR CDD; cd00637; 7tm_classA_rhodopsin-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24229:SF50; G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24229; NEUROPEPTIDES RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000688};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 46..69
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 121..147
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 182..204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 272..294
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 25..292
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 420 AA; 48129 MW; C9B9FDE252BB23E5 CRC64;
MSDSSQHLRL ALTVTHLLLV ALGSVNLIII LLIITRPYLR SITNVYMIGL CLADFIYLAD
LILVAATSLN GKSWPFGPTI CHLFHGTEAT GKYASVLFVV LLAADRYIAM CKSDLCGRYR
TYRTAIFLSG LAWIAAFICS LPLYVYADEI KVRMRPKNGT DSIENNHTLC IAHWPSPPHA
QWYISVCSVM IFILPGLVIF YCYYHVFCKL REAAKGSRRL HRNKRSRSSY QRVTRSVQRV
VLFHLLCWSP FWLFNLFSAI FRVRITTQLM RIIVNIIHLF PYVNCALNPV LYAYRAENFR
TAFKSLLFWS RRNRPLPLPE DVRSTSASTY YRNSSNLDCL KSSLPIKSTM EPASVYQPEE
ESPVDSTENL EMERKKAELQ AWRPYDGTNC EVLEVQYDHH KCSARSILLP AVTVDEGTKL
//
