ID Q2XP18_9PICO Unreviewed; 2248 AA.
AC Q2XP18;
DT 20-DEC-2005, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2005, sequence version 1.
DT 27-MAR-2024, entry version 134.
DE RecName: Full=Genome polyprotein {ECO:0000256|ARBA:ARBA00020107};
OS Equine rhinitis A virus.
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Picornavirales; Picornaviridae; Caphthovirinae; Aphthovirus.
OX NCBI_TaxID=47000 {ECO:0000313|EMBL:ABB76804.1, ECO:0000313|Proteomes:UP000174695};
RN [1] {ECO:0000313|EMBL:ABB76804.1, ECO:0000313|Proteomes:UP000174695}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T10 {ECO:0000313|EMBL:ABB76804.1};
RA Aminev A., Palmenberg A.;
RT "Comparative Genomics Among Equine Rhinitis A Viruses.";
RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004180}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004180}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004180}. Host cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004295}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004295}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004295}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}. Virion
CC {ECO:0000256|ARBA:ARBA00004328}.
CC -!- SIMILARITY: Belongs to the picornaviruses polyprotein family.
CC {ECO:0000256|ARBA:ARBA00008303}.
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DR EMBL; DQ272577; ABB76804.1; -; Genomic_RNA.
DR MEROPS; C28.002; -.
DR Proteomes; UP000174695; Genome.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044162; C:host cell cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0039618; C:T=pseudo3 icosahedral viral capsid; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0075509; P:endocytosis involved in viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0051259; P:protein complex oligomerization; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0019082; P:viral protein processing; IEA:InterPro.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR GO; GO:0039707; P:virus-mediated pore formation in host cell membrane; IEA:UniProtKB-KW.
DR CDD; cd00205; rhv_like; 3.
DR Gene3D; 1.20.960.20; -; 1.
DR Gene3D; 2.60.120.20; -; 3.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 4.10.90.10; Capsid protein VP4 superfamily, Picornavirus; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR015031; Capsid_VP4_Picornavir.
DR InterPro; IPR037080; Capsid_VP4_sf_Picornavirus.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR004004; Helic/Pol/Pept_Calicivir-typ.
DR InterPro; IPR000605; Helicase_SF3_ssDNA/RNA_vir.
DR InterPro; IPR014759; Helicase_SF3_ssRNA_vir.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR044067; PCV_3C_PRO.
DR InterPro; IPR008739; Peptidase_C28.
DR InterPro; IPR000199; Peptidase_C3A/C3B_picornavir.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001676; Picornavirus_capsid.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR033703; Rhv-like.
DR InterPro; IPR001205; RNA-dir_pol_C.
DR InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR InterPro; IPR029053; Viral_coat.
DR Pfam; PF05408; Peptidase_C28; 1.
DR Pfam; PF00548; Peptidase_C3; 1.
DR Pfam; PF00680; RdRP_1; 1.
DR Pfam; PF00073; Rhv; 2.
DR Pfam; PF00910; RNA_helicase; 1.
DR Pfam; PF08935; VP4_2; 1.
DR PRINTS; PR00918; CALICVIRUSNS.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF88633; Positive stranded ssRNA viruses; 2.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS51887; APHTHOVIRUS_LPRO; 1.
DR PROSITE; PS51874; PCV_3C_PRO; 1.
DR PROSITE; PS50507; RDRP_SSRNA_POS; 1.
DR PROSITE; PS51218; SF3_HELICASE_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Capsid protein {ECO:0000256|ARBA:ARBA00022561};
KW Covalent protein-RNA linkage {ECO:0000256|ARBA:ARBA00022520};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Host cytoplasm {ECO:0000256|ARBA:ARBA00023200};
KW Host cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00022488};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Myristate {ECO:0000256|ARBA:ARBA00022707};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484};
KW T=pseudo3 icosahedral capsid protein {ECO:0000256|ARBA:ARBA00022706};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW Viral ion channel {ECO:0000256|ARBA:ARBA00023039};
KW Viral penetration into host cytoplasm {ECO:0000256|ARBA:ARBA00022595};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953};
KW Virion {ECO:0000256|ARBA:ARBA00022706};
KW Virus endocytosis by host {ECO:0000256|ARBA:ARBA00022890};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT TRANSMEM 1071..1094
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1521..1546
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 31..184
FT /note="Peptidase C28"
FT /evidence="ECO:0000259|PROSITE:PS51887"
FT DOMAIN 1228..1392
FT /note="SF3 helicase"
FT /evidence="ECO:0000259|PROSITE:PS51218"
FT DOMAIN 1582..1776
FT /note="Peptidase C3"
FT /evidence="ECO:0000259|PROSITE:PS51874"
FT DOMAIN 2018..2136
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50507"
FT REGION 246..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2248 AA; 249712 MW; 91E76D34CA7CE35D CRC64;
MMAASKVYRV CEQTLLAGAV RMMDKFLQKR TVFVPHLDKT IRLTGLHNYD NTCWLNALTQ
LTQILGIRLF DEHFGNRGLF TRKTIDWVSD QTGIKDLKSG APPLVVVYKL WQHGHLDVGT
MEKPRSITLW SGPKVCLSDF WACVSAKPGH AVFYLLTSEG WICVDDKKIY PETPKTEDVL
VFAPYDFESL GKDPPKLHQR YEKAFERLSG AGTSTPTTGN QNMSGNSGSI VQNFYMQQYQ
NSIDADLGDN VISPEGQGSN TSSSTSSSQS SGLGGWFSSL LNLGTKLLAD KKTEETTNIE
DRIETTVVGV TIINSQGSVG TTYCYSKPDG RPPSTVSDPV TRLGPSLSRH YTFKVGEWPH
SQSHGHAWIC PLPGDKLKKM GSFHGVVKAH HLVKNGWDVV VQVNASFAHS GALCVAAVPE
YEHTHEKALK WSELEEPAYT YQQLSVFPHQ LLNLRTNSSV HLVMPYIGPG QPTNLALHNP
WTIVILILSE LTGPGQTVPV TMSVAPIDAM VNGPLPNPEA PIRVVSVPES DSFMSSVPDN
STPLYPKVVV PPRQVPGRFT NFIDVAKQTY SFCSISGKPY FMVTNTSGDE PLFQMDVSLS
AAELHGTYVA SLSSFFAQYR GSLNFNFIFT GAAATKAKFL VAFVPPHSAA PKTRDEAMAC
IHAVWDVGLN SAFSFNVPYS SPADFMAVYS AEATVVNVSG WLQVYALTAL TSTDIAVNSK
GRVLVAVSAG PDFSLRHPVD LPDKQVTNVG EDGEPGETEP RHALSPVDMH VHTDVSFLLD
RFFDVETLEL SNLTGSPATH VLDPFGSTAQ LAWARLLNTC TYFFSDLELS IQFKFTTTPS
SVGEGFVWVK WFPVGAPTKT TDAWQLEGGG NAVRIQKLAV AGLSPTVVFK IAGSRSQACA
SALPYTSMWR VVPVFYNGWG SPTKEKATYN WLPGAHFGSI LLTSDAHDKG GCYLRYRFPR
ANMYCPRPIP PAFTRPADKT RHKFPTNINK QCTNYSLLKL AGDVESNPGP IIFSKASADP
NALSTSLGEL TGLLKDLKAK AETYSPFYKM AKMLFKLATL AVAAMRTKDP VVVVMLIADF
GLEVFDTGFF FSYFQEKLQP YMKTIPGKIS DLVTDAATAA AQIPKGVYSF VSSFFETPEG
VVEKQVSLRT VNDIFTLLKN SDWFIKTLVA LKKWLTSWFA QEQQADDALY SELEKYPLYK
LKLKEPDTQK EARQWFKDMQ QRALAVKDKG LFSLLQIPLV DLPQSRPEPV VCVLRGASGQ
GKSYLANLMA QAISLLLVGK QNSVWSCPPD PTYFDGYNGQ AVVIMDDLGQ NPNGADFKYF
CQMVSTTAFV PPMAHLDDKG IPFTSPVVIC TTNLHSSFTP ITVSCPEALK RRFRFDVTVS
AKPGFVRTVG SSQLLNLPLA LKPAGLPPHP IFENDMPIIN GQAVKLALFG GEVTAFELIE
MILSEVQNRQ DTHKMPIFKQ SWSDLFRKCT TDEEQKMLQF LIDNKDSEIL RAFVSERSIL
LHEEYLKWES YMTRRAKFHR LAADFAMFLS ILTSLIVIFC LVYSMYQLFK TPDEHSAYDP
STKPKPKTQE VKTLKIRTET GVPATDLQQS IMKNVQPIEL YFDNELVTDC SALGVYDNSY
LVPLHLFEFD FDTIVLGGRH YKKADCEKVE FELEVNGDMV SSDACLLRVP SGPKVRNIVH
LFTNEIELKK MTQVTGIMNS PHQARTVFFG SFLTVRKSIL TSDGTVMPNV LSYAAQTSRG
YCGAAIVAGS PARIIGIHSA GTGSVAFCSL VSRDALERTL PQKQGNVSRL DDDVRVSVPR
RSKLVKSLAY PIFKPDYGPA PLSQFDKRLS DGVKLDEVVF AKHTGDKEIS AQDQKWLLRA
AHVYAQKVFS RIGFDNQALT EKEAICGIPG LDKMEQDTAP GLPYAQQNKR RKDICDFEEG
RLKGAAKFQK DRFMAGDYSD LIYQSFLKDE IRPLEKVRAG KTRLIDVPPM PHVVVGRQLL
GRFVAKFHEA NGFDIGSAIG CDPDVDWTRF GLELERFRYV YACDYSRFDA NHAADAMRVV
LNYFFSEDHG FDPGVPAFIE SLIDSVHAYE EKRYNIYGGL PSGCSCTSIL NTILNNVYIL
AAMMKAYENF EPDDIQVICY GDDCLIASDF EIDFQQLVPV FSSFGQVITT ADKTDFFKLT
TLSEVTFLKR AFVPDGAFYK PVMDVKTLEA ILSFVRPGTQ AEKLLSVAQL AGHCEPEQYE
RLFEPFVGMY FVPTWRDKRL QWLMKLGC
//
