ID   Q2XXV9_DROSI            Unreviewed;      1333 AA.
AC   Q2XXV9;
DT   20-DEC-2005, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2005, sequence version 1.
DT   27-MAR-2024, entry version 91.
DE   SubName: Full=CG6890 {ECO:0000313|EMBL:ABA86509.1};
DE   Flags: Fragment;
OS   Drosophila simulans (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7240 {ECO:0000313|EMBL:ABA86509.1};
RN   [1] {ECO:0000313|EMBL:ABA86509.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Ky-a {ECO:0000313|EMBL:ABA86509.1};
RX   PubMed=16120803; DOI=10.1093/molbev/msi246;
RA   Comeron J.M., Guthrie T.B.;
RT   "Intragenic Hill-Robertson interference influences selection intensity on
RT   synonymous mutations in Drosophila.";
RL   Mol. Biol. Evol. 22:2519-2530(2005).
CC   -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC       {ECO:0000256|ARBA:ARBA00009634}.
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DR   EMBL; DQ138903; ABA86509.1; -; Genomic_DNA.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0003401; P:axis elongation; IEA:EnsemblMetazoa.
DR   GO; GO:0060026; P:convergent extension; IEA:EnsemblMetazoa.
DR   GO; GO:0048935; P:peripheral nervous system neuron development; IEA:EnsemblMetazoa.
DR   GO; GO:0060049; P:regulation of protein glycosylation; IEA:EnsemblMetazoa.
DR   GO; GO:0007165; P:signal transduction; IEA:EnsemblMetazoa.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 8.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR026906; LRR_5.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR45712:SF28; AGAP007037-PA; 1.
DR   PANTHER; PTHR45712; AGAP008170-PA; 1.
DR   Pfam; PF13306; LRR_5; 1.
DR   Pfam; PF13855; LRR_8; 5.
DR   Pfam; PF13676; TIR_2; 1.
DR   PRINTS; PR01537; INTRLKN1R1F.
DR   SMART; SM00365; LRR_SD22; 10.
DR   SMART; SM00369; LRR_TYP; 23.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF52058; L domain-like; 4.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS51450; LRR; 8.
DR   PROSITE; PS50104; TIR; 1.
PE   3: Inferred from homology;
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..1333
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004218571"
FT   TRANSMEM        1012..1036
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1067..1202
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
FT   REGION          1228..1333
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1263..1297
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ABA86509.1"
FT   NON_TER         1333
FT                   /evidence="ECO:0000313|EMBL:ABA86509.1"
SQ   SEQUENCE   1333 AA;  151741 MW;  7868B6081C1D7358 CRC64;
     LYVLIATCVI PIFGAALSKT VLYQAPDECR WSGGGEHDIT LVCHLRTINS ELENTNFSVI
     QPQNTVRLRL ECNDALFFQS SLSPDSFRSL VELRDLTIEY CKLGNLTDGS FRGLQELRNL
     TIRTHNGDWS TMSLEMASNS FVEFRQLERL DLSLNNIWLI PDGMVCPLKS LQHLNASYNK
     IQDISNFYFS ASLSSRKARV CGSTLQSLDL SANKMVSLPT AMLSALGRLT HLNMAKNSMS
     FLADRAFEGL LSLRVVDLSA NRLTSLPPEL FAETKQLQEI YLRNNSINVL APGIFGELAE
     LLVLDLASNE LNSQWINAAT FVGLKRLMML DLSANKISRL EAHIFRPLAS LQILKLEDNY
     IDQLPGGIFA DLTNLHTLIL SHNRISVIEQ RTLQGLKNLL VLSLDFNRIS RMDQRSLVNC
     SQLQDLHLND NKLQTVPEAL AHVPLLKTLD VGENMISQIE NSSITQLESL YGLRMTENSL
     THIRRGVFDR MSSLQILNLS QNKLKSIEAG SLQRNIQLQA IRLDGNQLKS IAGLFTELPN
     LVWMNISGNR LEKFDYSHIP IGLQWLDVRA NRITQLGNYF EIESELSLST FDASYNLLTE
     ITASSIPNSV EVLYLNDNQI SKIQPYTFFK KPNLTRVDLV RNRLTTLEPN ALRLSPIAED
     REIPEFYIGH NAYECDCNLD WLQKVNRESR TQPQLMDLDQ IHCRLAYARG SSHVSLIEAK
     SDDFLCKYAS HCFALCHCCD FQACDCKMEC PDRCSCYHDQ SWTSNVVDCS RASYEQTLPS
     HIPMDSTQLY LDGNNFRELQ SHAFIGRKRL KVLHLNHSRI EVLHNRTFYG LLELEVLQLQ
     SNQLKALNGN EFQGLDNLQE LYLQHNAIAT IDTLTFTHLY HLKILRLDHN AITSFAVWNF
     LPSYLNELRL ASNPWTCSCE FIDKLRDYMN RHEYAVDKLK MKCDVISGNS TQQMVIYPGS
     GEAATLPVVQ CSQTLPLGLD NSFNYAEQAG GENASNATST KMILNQPPKL DYIPILVAIL
     TAFIFVMICI SLVFIFRQEM RVWCHSRFGV RLFYNAQKDV DKNEREKLFD AFVSYSSKDE
     LFVNEELAPM LEMGEHRYKL CLHQRDFPVG GYLPETIVQA IDSSRRTIMV VSENFIKSEW
     CRFEFKSAHQ SVLRDRRRRL IVIVLGEVPQ KELDPDLRLY LKTNTYLQWG DKLFWQKLRF
     ALPDVSSSQR SNVAGQSCHV PINHASYHHH HHVHQQAMPL PHSVHHHQQQ FMLPPPPQQP
     GSFRRQPSLH QQQQQQQQLR GNNNTTQQQQ QQQAALLMGG GSVGGPAPQM IPLAGGIQQQ
     SLPLPPNQQP TPA
//