ID Q2YCL1_NITMU Unreviewed; 1054 AA.
AC Q2YCL1;
DT 20-DEC-2005, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2005, sequence version 1.
DT 27-MAR-2024, entry version 111.
DE SubName: Full=Diguanylate cyclase/phosphodiesterase with PAS/PAC and Chase sensor(S) {ECO:0000313|EMBL:ABB73510.1};
GN OrderedLocusNames=Nmul_A0202 {ECO:0000313|EMBL:ABB73510.1};
GN ORFNames=SAMN05216403_11095 {ECO:0000313|EMBL:SEF82262.1};
OS Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849 / C 71).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC Nitrosomonadaceae; Nitrosospira.
OX NCBI_TaxID=323848 {ECO:0000313|EMBL:ABB73510.1, ECO:0000313|Proteomes:UP000002718};
RN [1] {ECO:0000313|Proteomes:UP000002718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25196 / NCIMB 11849 / C 71
RC {ECO:0000313|Proteomes:UP000002718};
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M.,
RA Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Lykidis A., Richardson P.;
RT "Complete sequence of chromosome 1 of Nitrosospira multiformis ATCC
RT 25196.";
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ABB73510.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 25196 {ECO:0000313|EMBL:ABB73510.1};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M.,
RA Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Lykidis A., Richardson P.;
RT "Complete sequence of Chromosome 1 of Nitrosospira multiformis ATCC
RT 25196.";
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ABB73510.1, ECO:0000313|Proteomes:UP000002718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25196 {ECO:0000313|EMBL:ABB73510.1}, and ATCC 25196 /
RC NCIMB 11849 / C 71 {ECO:0000313|Proteomes:UP000002718};
RX PubMed=18390676; DOI=10.1128/AEM.02722-07;
RA Norton J.M., Klotz M.G., Stein L.Y., Arp D.J., Bottomley P.J., Chain P.S.,
RA Hauser L.J., Land M.L., Larimer F.W., Shin M.W., Starkenburg S.R.;
RT "Complete genome sequence of Nitrosospira multiformis, an ammonia-oxidizing
RT bacterium from the soil environment.";
RL Appl. Environ. Microbiol. 74:3559-3572(2008).
RN [4] {ECO:0000313|EMBL:SEF82262.1, ECO:0000313|Proteomes:UP000236751}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nl13 {ECO:0000313|EMBL:SEF82262.1,
RC ECO:0000313|Proteomes:UP000236751};
RA de Groot N.N.;
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP000103; ABB73510.1; -; Genomic_DNA.
DR EMBL; FNVK01000010; SEF82262.1; -; Genomic_DNA.
DR RefSeq; WP_011379564.1; NZ_FNVK01000010.1.
DR AlphaFoldDB; Q2YCL1; -.
DR STRING; 323848.Nmul_A0202; -.
DR KEGG; nmu:Nmul_A0202; -.
DR eggNOG; COG3614; Bacteria.
DR eggNOG; COG5000; Bacteria.
DR eggNOG; COG5001; Bacteria.
DR HOGENOM; CLU_000445_70_59_4; -.
DR OrthoDB; 9813903at2; -.
DR Proteomes; UP000002718; Chromosome.
DR Proteomes; UP000236751; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:UniProt.
DR CDD; cd01948; EAL; 1.
DR CDD; cd01949; GGDEF; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.30.450.350; CHASE domain; 1.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR006189; CHASE_dom.
DR InterPro; IPR042240; CHASE_sf.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013656; PAS_4.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR NCBIfam; TIGR00229; sensory_box; 2.
DR PANTHER; PTHR44757:SF11; DIGUANYLATE CYCLASE DGCE-RELATED; 1.
DR PANTHER; PTHR44757; DIGUANYLATE CYCLASE DGCP; 1.
DR Pfam; PF03924; CHASE; 1.
DR Pfam; PF00563; EAL; 1.
DR Pfam; PF00990; GGDEF; 1.
DR Pfam; PF08448; PAS_4; 1.
DR Pfam; PF13426; PAS_9; 1.
DR SMART; SM01079; CHASE; 1.
DR SMART; SM00052; EAL; 1.
DR SMART; SM00267; GGDEF; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50839; CHASE; 1.
DR PROSITE; PS50883; EAL; 1.
DR PROSITE; PS50887; GGDEF; 1.
DR PROSITE; PS50113; PAC; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002718};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 320..341
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 145..304
FT /note="CHASE"
FT /evidence="ECO:0000259|PROSITE:PS50839"
FT DOMAIN 375..420
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 495..547
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 565..617
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 649..788
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 797..1050
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
SQ SEQUENCE 1054 AA; 119323 MW; 70782FC446EFC18D CRC64;
MDTEIHNPHI PGGRPPSRPA IAALTFVIFM SLTLASWSVV QDLQERHENT RFDKRVAEVI
HKIEHHFSGY EQVLKGALGH LLASPSVSRN EWRTYVNALR INDRYPGIHG IGFAKYIPRS
GLAAHTEEVR AEGFPSYKVW PGTPRQEYTS IIYLEPFTGS NLRAFGYDMF SNAVRRAAMS
RARDTGEVAL TRKVKLVQET GEDIQAGVLM YLPYYGAANL PKTVEERRAS LGGYVYAPFR
MVDFVRATLG SELDILDLRI FDGKAMAEDS LLFDSVKHRS GPSPVPKFKR VIPISLYGQT
WALEASSRPA FEKAIKNYEA LLVLLGGFVV SMLTAMVSFV LSGNKEKAAA LGHVNKKLLL
AMEEQQATTR ELSNAKLRTE RILESITDAF YTLDREWRFT YVNKEAENLL QRNREDLLGR
VCWEEFKETA GTTFDREYHR ALMENRTVTF EEFYVPLDEW FEVHAYPSEE GLTVYFRDIT
ERKESEQARQ EAHVRIRQQA SLLDKATDAI IVFGMDNCIE FWNQGAERLY GWTSEEVMGR
EVEMLYDNVA VFDEANRALL SSGEWRGELA QRRRDQSMLN VEAHWTLVRN DDGEPQAIFA
INTDITQRKS AENEILHLAL YDSLTGLPNR RLLLDRLGHA LAVSARNQRM GALLFIDLDN
FKLLNDTLGH DMGDLLLRQV APRLSSCVRE SDTVARLGGD EFVVILMGDF GEDHDEALTQ
ISTICERIRS AFIQPFNLDP YIHHITPSIG IALFNDQSQT TNELLKRADL AMYQAKASGR
NAMRFFDPDM QAAMNARAIL ESELYKSWER NEFILHYQLQ VDSRGIIGAE ALVRWQHPRR
GLLPPSEFIP QAEETGLILP LGEWVLETAC NQLASWALQP ETVQLNLSVN VSSLQFCQPD
FVEQVISILD RTGANPQRLK LELTESILVH DMDDTIAKMM TLKARGVGFA LDDFGIGYSS
LYYLKRLPLD WVKIDRSFVR DVLTDNNDAT IVRTILLLAK SMGLAVIAEG VETGAQKDFL
ASHGCTAYQG YLFSRPLPLE QFERFVQPAA GGAV
//
