ID   Q309X6_STRPY            Unreviewed;       381 AA.
AC   Q309X6;
DT   06-DEC-2005, integrated into UniProtKB/TrEMBL.
DT   06-DEC-2005, sequence version 1.
DT   27-MAR-2024, entry version 57.
DE   SubName: Full=Putative serine protease {ECO:0000313|EMBL:ABB20901.1};
DE   Flags: Fragment;
GN   Name=htrA {ECO:0000313|EMBL:ABB20901.1};
OS   Streptococcus pyogenes.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1314 {ECO:0000313|EMBL:ABB20901.1};
RN   [1] {ECO:0000313|EMBL:ABB20901.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NS931 {ECO:0000313|EMBL:ABB20901.1};
RX   PubMed=18072207; DOI=10.1002/pmic.200700626;
RA   Cole J.N., Aquilina J.A., Hains P.G., Henningham A., Sriprakash K.S.,
RA   Caparon M.G., Nizet V., Kotb M., Cordwell S.J., Djordjevic S.P.,
RA   Walker M.J.;
RT   "Role of group A Streptococcus HtrA in the maturation of SpeB protease.";
RL   Proteomics 7:4488-4498(2007).
CC   -!- SIMILARITY: Belongs to the peptidase S1C family.
CC       {ECO:0000256|ARBA:ARBA00010541}.
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DR   EMBL; DQ230906; ABB20901.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q309X6; -.
DR   MEROPS; S01.447; -.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00987; PDZ_serine_protease; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR   InterPro; IPR001940; Peptidase_S1C.
DR   PANTHER; PTHR43343; PEPTIDASE S12; 1.
DR   PANTHER; PTHR43343:SF3; PROTEASE DO-LIKE 8, CHLOROPLASTIC; 1.
DR   Pfam; PF13180; PDZ_2; 1.
DR   Pfam; PF13365; Trypsin_2; 1.
DR   PRINTS; PR00834; PROTEASES2C.
DR   SMART; SM00228; PDZ; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 1.
DR   SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR   PROSITE; PS50106; PDZ; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022825};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:ABB20901.1};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825}.
FT   DOMAIN          259..361
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ABB20901.1"
SQ   SEQUENCE   381 AA;  39999 MW;  07DF158B19E40225 CRC64;
     TFNNLYPHSP SKINSGKATT SNMVFNNTTN TTKAVKAVQN AVVSVINYQD NPSSSLSNPY
     TKLFGEGRSK ENKDAELSIF SEGSGVIYRK DGNSAYVVTN NHVIDGAKRI EILMADGSKV
     VGELVGADTY SDLAVVKISS DKIKTVAEFA DSTKLNVGEV AIAIGSPLGT QYANSVTQGI
     VSSLSRTVTL KNENGETVST NAIQTDAAIN PGNSGGPLIN IEGQVIGINS SKISSTPTGS
     NGNSGAVEGI GFAIPSTDVI KIIKQLETNG EVIRPALGIS MVNLNDLSTN ALSQINIPTS
     VTGGIVVAEV KEGMPASGKL AQYDVITEID GKTVNSISDL QSSLYGHDIN DTIKVTFYRG
     TTKKKADIKL TKTTQDLTKT Q
//