GenomeNet

Database: UniProt
Entry: Q37705
LinkDB: Q37705
Original site: Q37705 
ID   COX1_ARTSF              Reviewed;         512 AA.
AC   Q37705;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   01-OCT-2014, entry version 87.
DE   RecName: Full=Cytochrome c oxidase subunit 1;
DE            EC=1.9.3.1;
DE   AltName: Full=Cytochrome c oxidase polypeptide I;
GN   Name=COI; Synonyms=CO-I;
OS   Artemia franciscana (Brine shrimp) (Artemia sanfranciscana).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC   Anostraca; Artemiidae; Artemia.
OX   NCBI_TaxID=6661;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8169960; DOI=10.1007/BF00166162;
RA   Perez M.L., Valverde J.R., Batuecas B., Amat F., Marco R., Garesse R.;
RT   "Speciation in the Artemia genus: mitochondrial DNA analysis of
RT   bisexual and parthenogenetic brine shrimps.";
RL   J. Mol. Evol. 38:156-168(1994).
CC   -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory
CC       chain that catalyzes the reduction of oxygen to water. Subunits 1-
CC       3 form the functional core of the enzyme complex. CO I is the
CC       catalytic subunit of the enzyme. Electrons originating in
CC       cytochrome c are transferred via the copper A center of subunit 2
CC       and heme A of subunit 1 to the bimetallic center formed by heme A3
CC       and copper B.
CC   -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4
CC       ferricytochrome c + 2 H(2)O.
CC   -!- PATHWAY: Energy metabolism; oxidative phosphorylation.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass
CC       membrane protein.
CC   -!- SIMILARITY: Belongs to the heme-copper respiratory oxidase family.
CC       {ECO:0000305}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; X69067; CAA48806.1; -; Genomic_DNA.
DR   PIR; S60622; S60622.
DR   RefSeq; NP_007109.1; NC_001620.1.
DR   ProteinModelPortal; Q37705; -.
DR   SMR; Q37705; 1-510.
DR   GeneID; 807790; -.
DR   CTD; 4512; -.
DR   UniPathway; UPA00705; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0009060; P:aerobic respiration; IEA:InterPro.
DR   GO; GO:0006119; P:oxidative phosphorylation; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.20.210.10; -; 1.
DR   InterPro; IPR000883; COX1.
DR   InterPro; IPR023615; Cyt_c_Oxase_su1_BS.
DR   InterPro; IPR023616; Cyt_c_Oxase_su1_dom.
DR   PANTHER; PTHR10422; PTHR10422; 1.
DR   Pfam; PF00115; COX1; 1.
DR   PRINTS; PR01165; CYCOXIDASEI.
DR   SUPFAM; SSF81442; SSF81442; 1.
DR   PROSITE; PS50855; COX1; 1.
DR   PROSITE; PS00077; COX1_CUB; 1.
PE   3: Inferred from homology;
KW   Copper; Electron transport; Heme; Iron; Membrane; Metal-binding;
KW   Mitochondrion; Mitochondrion inner membrane; Oxidoreductase;
KW   Respiratory chain; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN         1    512       Cytochrome c oxidase subunit 1.
FT                                /FTId=PRO_0000183287.
FT   TRANSMEM     15     35       Helical. {ECO:0000255}.
FT   TRANSMEM     54     74       Helical. {ECO:0000255}.
FT   TRANSMEM    100    120       Helical. {ECO:0000255}.
FT   TRANSMEM    143    163       Helical. {ECO:0000255}.
FT   TRANSMEM    181    201       Helical. {ECO:0000255}.
FT   TRANSMEM    232    252       Helical. {ECO:0000255}.
FT   TRANSMEM    266    286       Helical. {ECO:0000255}.
FT   TRANSMEM    303    323       Helical. {ECO:0000255}.
FT   TRANSMEM    336    356       Helical. {ECO:0000255}.
FT   TRANSMEM    378    398       Helical. {ECO:0000255}.
FT   TRANSMEM    412    432       Helical. {ECO:0000255}.
FT   TRANSMEM    450    470       Helical. {ECO:0000255}.
FT   METAL        59     59       Iron (heme A axial ligand).
FT                                {ECO:0000305}.
FT   METAL       238    238       Copper B. {ECO:0000305}.
FT   METAL       242    242       Copper B. {ECO:0000305}.
FT   METAL       288    288       Copper B. {ECO:0000305}.
FT   METAL       289    289       Copper B. {ECO:0000305}.
FT   METAL       374    374       Iron (heme A3 axial ligand).
FT                                {ECO:0000305}.
FT   METAL       376    376       Iron (heme A axial ligand).
FT                                {ECO:0000305}.
FT   CROSSLNK    238    242       1'-histidyl-3'-tyrosine (His-Tyr).
FT                                {ECO:0000250}.
SQ   SEQUENCE   512 AA;  56492 MW;  4AA1E1BBE64913E3 CRC64;
     MQRWFYSTNH KDIGTLYFIF GAWAGMVGTS LSMLIRAELG QPGSLIGDEQ VYNVIVTAHA
     FIMIFFMVMP ILIGGFGNWL VPIMLGAPDM AFPRLNNLSF WMLPPSLTLL LASSMVESGA
     GTGWTVYPPL SSAIAHAGPS VDLAIFSLHL AGVSSILGAV NFITTIINMR PQSMSIDRMP
     LFVWAVGITA VLLLLSLPVL AGAITMLLTD RNLNTSFFDP AGGGDPILYQ HLFWFFGHPE
     VYILILPGFG MVSHIISQES GKKEAFGTLG MIYAMLAIGI LGFVVWAHHM FTVGMDVDTR
     AYFTAATMII AIPTGIKIFS WIGTLHGTRL TMTPSMLWAL GFVFLFTVGG LTGVVLSNSS
     IDIVLHDTYY VVAHFHYVLS MGAVFAIMAG FVHWFPLMTG LSMNQFLLKV HFFIMFLGVN
     LTFFPQHFLG LAGMPRRYAD YPDTYASWNV ISSLGSVMSM IATLMFIFCI WEAMIAKRIN
     IFSLNLSSSV EWNHPHPPAD HSYEEITMIS TF
//
DBGET integrated database retrieval system