ID COX1_ARTSF Reviewed; 512 AA.
AC Q37705;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-APR-2013, entry version 80.
DE RecName: Full=Cytochrome c oxidase subunit 1;
DE EC=1.9.3.1;
DE AltName: Full=Cytochrome c oxidase polypeptide I;
GN Name=COI; Synonyms=CO-I;
OS Artemia franciscana (Brine shrimp) (Artemia sanfranciscana).
OG Mitochondrion.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Anostraca; Artemiidae; Artemia.
OX NCBI_TaxID=6661;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8169960; DOI=10.1007/BF00166162;
RA Perez M.L., Valverde J.R., Batuecas B., Amat F., Marco R., Garesse R.;
RT "Speciation in the Artemia genus: mitochondrial DNA analysis of
RT bisexual and parthenogenetic brine shrimps.";
RL J. Mol. Evol. 38:156-168(1994).
CC -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory
CC chain that catalyzes the reduction of oxygen to water. Subunits 1-
CC 3 form the functional core of the enzyme complex. CO I is the
CC catalytic subunit of the enzyme. Electrons originating in
CC cytochrome c are transferred via the copper A center of subunit 2
CC and heme A of subunit 1 to the bimetallic center formed by heme A3
CC and copper B.
CC -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4
CC ferricytochrome c + 2 H(2)O.
CC -!- PATHWAY: Energy metabolism; oxidative phosphorylation.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass
CC membrane protein.
CC -!- SIMILARITY: Belongs to the heme-copper respiratory oxidase family.
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DR EMBL; X69067; CAA48806.1; -; Genomic_DNA.
DR PIR; S60622; S60622.
DR RefSeq; NP_007109.1; NC_001620.1.
DR ProteinModelPortal; Q37705; -.
DR SMR; Q37705; 1-510.
DR GeneID; 807790; -.
DR CTD; 4512; -.
DR UniPathway; UPA00705; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:EC.
DR GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0009060; P:aerobic respiration; IEA:InterPro.
DR GO; GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
DR GO; GO:0006119; P:oxidative phosphorylation; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.20.210.10; -; 1.
DR InterPro; IPR000883; Cyt_c_Oxase_su1.
DR InterPro; IPR023615; Cyt_c_Oxase_su1_BS.
DR InterPro; IPR023616; Cyt_c_Oxase_su1_dom.
DR PANTHER; PTHR10422; PTHR10422; 1.
DR Pfam; PF00115; COX1; 1.
DR PRINTS; PR01165; CYCOXIDASEI.
DR SUPFAM; SSF81442; COX1; 1.
DR PROSITE; PS50855; COX1; 1.
DR PROSITE; PS00077; COX1_CUB; 1.
PE 3: Inferred from homology;
KW Copper; Electron transport; Heme; Iron; Membrane; Metal-binding;
KW Mitochondrion; Mitochondrion inner membrane; Oxidoreductase;
KW Respiratory chain; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1 512 Cytochrome c oxidase subunit 1.
FT /FTId=PRO_0000183287.
FT TRANSMEM 15 35 Helical; (Potential).
FT TRANSMEM 54 74 Helical; (Potential).
FT TRANSMEM 100 120 Helical; (Potential).
FT TRANSMEM 143 163 Helical; (Potential).
FT TRANSMEM 181 201 Helical; (Potential).
FT TRANSMEM 232 252 Helical; (Potential).
FT TRANSMEM 266 286 Helical; (Potential).
FT TRANSMEM 303 323 Helical; (Potential).
FT TRANSMEM 336 356 Helical; (Potential).
FT TRANSMEM 378 398 Helical; (Potential).
FT TRANSMEM 412 432 Helical; (Potential).
FT TRANSMEM 450 470 Helical; (Potential).
FT METAL 59 59 Iron (heme A axial ligand) (Probable).
FT METAL 238 238 Copper B (Probable).
FT METAL 242 242 Copper B (Probable).
FT METAL 288 288 Copper B (Probable).
FT METAL 289 289 Copper B (Probable).
FT METAL 374 374 Iron (heme A3 axial ligand) (Probable).
FT METAL 376 376 Iron (heme A axial ligand) (Probable).
FT CROSSLNK 238 242 1'-histidyl-3'-tyrosine (His-Tyr) (By
FT similarity).
SQ SEQUENCE 512 AA; 56492 MW; 4AA1E1BBE64913E3 CRC64;
MQRWFYSTNH KDIGTLYFIF GAWAGMVGTS LSMLIRAELG QPGSLIGDEQ VYNVIVTAHA
FIMIFFMVMP ILIGGFGNWL VPIMLGAPDM AFPRLNNLSF WMLPPSLTLL LASSMVESGA
GTGWTVYPPL SSAIAHAGPS VDLAIFSLHL AGVSSILGAV NFITTIINMR PQSMSIDRMP
LFVWAVGITA VLLLLSLPVL AGAITMLLTD RNLNTSFFDP AGGGDPILYQ HLFWFFGHPE
VYILILPGFG MVSHIISQES GKKEAFGTLG MIYAMLAIGI LGFVVWAHHM FTVGMDVDTR
AYFTAATMII AIPTGIKIFS WIGTLHGTRL TMTPSMLWAL GFVFLFTVGG LTGVVLSNSS
IDIVLHDTYY VVAHFHYVLS MGAVFAIMAG FVHWFPLMTG LSMNQFLLKV HFFIMFLGVN
LTFFPQHFLG LAGMPRRYAD YPDTYASWNV ISSLGSVMSM IATLMFIFCI WEAMIAKRIN
IFSLNLSSSV EWNHPHPPAD HSYEEITMIS TF
//
