ID Q38AS4_TRYB2 Unreviewed; 466 AA.
AC Q38AS4;
DT 22-NOV-2005, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2005, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EAN78096.1};
GN ORFNames=Tb10.6k15.3940 {ECO:0000313|EMBL:EAN78096.1};
OS Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=185431 {ECO:0000313|EMBL:EAN78096.1, ECO:0000313|Proteomes:UP000008524};
RN [1] {ECO:0000313|EMBL:EAN78096.1, ECO:0000313|Proteomes:UP000008524}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:EAN78096.1,
RC ECO:0000313|Proteomes:UP000008524};
RX PubMed=16020726; DOI=10.1126/science.1112642;
RA Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H.,
RA Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U.,
RA Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B.,
RA Alsmark U.C., Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F.,
RA Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C.,
RA Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A.,
RA Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D.,
RA Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D.,
RA Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S.,
RA Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S.,
RA Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G.,
RA Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A.,
RA Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M.,
RA Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S.,
RA Walker D., Wanless D., Wang S., White B., White O., Whitehead S.,
RA Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E.,
RA Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E.,
RA Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.;
RT "The genome of the African trypanosome Trypanosoma brucei.";
RL Science 309:416-422(2005).
CC -!- SIMILARITY: Belongs to the BBS4 family.
CC {ECO:0000256|ARBA:ARBA00023778}.
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DR EMBL; CM000208; EAN78096.1; -; Genomic_DNA.
DR RefSeq; XP_822924.1; XM_817831.1.
DR AlphaFoldDB; Q38AS4; -.
DR STRING; 185431.Q38AS4; -.
DR PaxDb; 5691-EAN78096; -.
DR GeneID; 3662729; -.
DR KEGG; tbr:Tb10.6k15.3940; -.
DR VEuPathDB; TriTrypDB:Tb11.v5.0539; -.
DR VEuPathDB; TriTrypDB:Tb927.10.6830; -.
DR eggNOG; KOG1124; Eukaryota.
DR InParanoid; Q38AS4; -.
DR OMA; YCEVAWH; -.
DR OrthoDB; 5481067at2759; -.
DR Proteomes; UP000008524; Chromosome 10.
DR GO; GO:0034464; C:BBSome; IPI:GeneDB.
DR GO; GO:0036064; C:ciliary basal body; IBA:GO_Central.
DR GO; GO:0020018; C:ciliary pocket membrane; IDA:GeneDB.
DR GO; GO:0035869; C:ciliary transition zone; IDA:GeneDB.
DR GO; GO:0030665; C:clathrin-coated vesicle membrane; IDA:GeneDB.
DR GO; GO:0032050; F:clathrin heavy chain binding; IPI:GeneDB.
DR GO; GO:0043130; F:ubiquitin binding; IDA:GeneDB.
DR GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR GO; GO:0061512; P:protein localization to cilium; IBA:GO_Central.
DR GO; GO:0033572; P:transferrin transport; IMP:GeneDB.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR44186; -; 1.
DR PANTHER; PTHR44186:SF1; BARDET-BIEDL SYNDROME 4 PROTEIN; 1.
DR Pfam; PF13432; TPR_16; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00028; TPR; 7.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50005; TPR; 2.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Reference proteome {ECO:0000313|Proteomes:UP000008524};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT REPEAT 95..128
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 303..336
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 466 AA; 51895 MW; 7458B6AAC91D55CB CRC64;
MEKKGSGRGA GARESKSSAV AATCKHQHPL PPSKPGGVEG TGAVETGTIK EEVASRDKIR
ERRNWLIYEL YVRQEYSQCC AVIDAQLAEC NGTCEYALFV KGLLTRRSGD LTISFQHFQK
ALTLNPGSPA CLQQLAQTSL LLGKFYEAIE SFQRAEEARA ARGFRKDWSL QYGVGLCYEY
MREYRKAEEA FVSSMQIQRF DCTVLRLSKV LVLQKQHSRA ISLLEEAVLG SPDNPDMLTV
LGLLYLRVDR PAKAFNYLGR CLILNSSDSR ATMAAASIMQ ENGEFGVALN KYRVAVPKLP
SSACLWSNIG MCFFGQKNMH AAVACLRRAA SLSPFEWRIA YNLGLVFLHL KQYASAFHYL
SASTHLHGKY ALAFMHIGVC LALMSDSDNA CAAYNRAISI QDDPLIRLNY CITLVHCGKD
AEARDQLDKF IQMRERGKEN SQQHPQLDVG PVVPRALTLL TAKLRK
//
