ID Q3HNP5_CAVPO Unreviewed; 379 AA.
AC Q3HNP5;
DT 08-NOV-2005, integrated into UniProtKB/TrEMBL.
DT 08-NOV-2005, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=Beta-3 adrenergic receptor {ECO:0000256|ARBA:ARBA00021558};
DE AltName: Full=Beta-3 adrenoreceptor {ECO:0000256|ARBA:ARBA00030352};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|EMBL:ABA46870.1};
RN [1] {ECO:0000313|EMBL:ABA46870.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Heart {ECO:0000313|EMBL:ABA46870.1};
RA Lau Y.M., Au L.S., Seto S.W., Kwan Y.W., Tsui K.W., Liu W.K.;
RT "Nitric oxide-mediated beta 3-adrenoceptor inhibition of basal L-type Ca2+
RT channels of guinea-pig single ventricular myocyte.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Beta-adrenergic receptors mediate the catecholamine-induced
CC activation of adenylate cyclase through the action of G proteins. Beta-
CC 3 is involved in the regulation of lipolysis and thermogenesis.
CC {ECO:0000256|ARBA:ARBA00003285}.
CC -!- SUBUNIT: Interacts with ARRDC3. {ECO:0000256|ARBA:ARBA00011154}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR EMBL; DQ205419; ABA46870.1; -; mRNA.
DR RefSeq; NP_001166358.1; NM_001172887.1.
DR AlphaFoldDB; Q3HNP5; -.
DR GeneID; 100135478; -.
DR KEGG; cpoc:100135478; -.
DR CTD; 155; -.
DR OrthoDB; 2900736at2759; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004939; F:beta-adrenergic receptor activity; IEA:InterPro.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IEA:InterPro.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR002233; ADR_fam.
DR InterPro; IPR000681; ADRB3_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24248; ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR24248:SF3; BETA-3 ADRENERGIC RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR01103; ADRENERGICR.
DR PRINTS; PR00563; ADRENRGCB3AR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000688};
KW Transducer {ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 36..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 69..90
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 110..131
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 209..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 293..313
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 325..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 52..345
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 246..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 379 AA; 40324 MW; 9F506D2C634050EE CRC64;
MASWTAPWTP GNRSLGSWPD APTLAPDPSG PPGVPWAAAV AGTLLALATV GGNLLVTAAI
ALTPRLQTIT NVFVTSLAAA DLVVGLLVVP PGATLALTGH WPLGTTGCEL WTSLDVLCVT
ASIETLCALA VDRYLAVTNP LRYRAVVTKR RARAAVALVW AVAAAVSFAP IMSQWWRAGA
DAEAQLCHGN PRCCAFVSNV PYAPLSSSVS FYLPLLVMLF VYARVFLVAQ RQLRLLREEV
GRFPPQGSPR IRSRSASPAQ GAGMRTAPAC EAPCGPRPAR LLPLRERRAL RTLGLIVGTF
ALCWLPFFLA NVLRALGGPS LVPNSVLLTL NWLGYINSAF YPLIYCRSPD FRSAFRRPVC
GCPGRGPPGR ANPAGRTAR
//
