ID Q3I8S4_MONPV Unreviewed; 1286 AA.
AC Q3I8S4;
DT 08-NOV-2005, integrated into UniProtKB/TrEMBL.
DT 08-NOV-2005, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=DNA-directed RNA polymerase 147 kDa polypeptide {ECO:0000256|ARBA:ARBA00021673};
DE EC=2.7.7.6 {ECO:0000256|ARBA:ARBA00012418};
GN Name=J6R {ECO:0000313|EMBL:AKS47996.1};
GN Synonyms=L6R {ECO:0000313|EMBL:AGR34451.1};
GN ORFNames=MPXV-CAM1990_02-082 {ECO:0000313|EMBL:AIE41232.1},
GN MPXV-Congo_8-083 {ECO:0000313|EMBL:AIE40353.1}, MPXV-GAB1988_001-083
GN {ECO:0000313|EMBL:AIE41410.1}, MPXV-Ikubi-082
GN {ECO:0000313|EMBL:AIE40175.1}, MPXV_DRC_Yandongi_091
GN {ECO:0000313|EMBL:AGF36853.1}, MPXV_RCG2003_358_095
GN {ECO:0000313|EMBL:AAY97089.1}, MPXV_ROC_2010_034
GN {ECO:0000313|EMBL:AGF36994.1}, MPXV_SUD2005_01_091
GN {ECO:0000313|EMBL:AGF36646.1}, MPXV_ZAI1979_005_095
GN {ECO:0000313|EMBL:AAY97290.1}, MPXVgp090
GN {ECO:0000313|EMBL:AGR34451.1};
OS Monkeypox virus.
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX NCBI_TaxID=10244 {ECO:0000313|EMBL:AAY97290.1, ECO:0000313|Proteomes:UP000099051};
OH NCBI_TaxID=45479; Cynomys gunnisoni (Gunnison's prairie dog) (Spermophilus gunnisoni).
OH NCBI_TaxID=99825; Cynomys leucurus (White-tailed prairie dog).
OH NCBI_TaxID=45480; Cynomys ludovicianus (Black-tailed prairie dog).
OH NCBI_TaxID=99826; Cynomys mexicanus (Mexican prairie dog).
OH NCBI_TaxID=99827; Cynomys parvidens (Utah prairie dog).
OH NCBI_TaxID=30650; Gliridae (dormice).
OH NCBI_TaxID=226685; Heliosciurus ruwenzorii (Ruwenzori sun squirrel).
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=10090; Mus musculus (Mouse).
RN [1] {ECO:0000313|Proteomes:UP000099051, ECO:0000313|Proteomes:UP000100082}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Congo_2003_358 {ECO:0000313|EMBL:AAY97089.1}, and
RC Zaire_1979-005 {ECO:0000313|EMBL:AAY97290.1};
RX PubMed=16186219; DOI=10.1099/vir.0.81215-0;
RA Likos A.M., Sammons S.A., Olson V.A., Frace A.M., Li Y.,
RA Olsen-Rasmussen M., Davidson W., Galloway R., Khristova M.L.,
RA Reynolds M.G., Zhao H., Carroll D.S., Curns A., Formenty P., Esposito J.J.,
RA Regnery R.L., Damon I.K.;
RT "A tale of two clades: monkeypox viruses.";
RL J. Gen. Virol. 86:2661-2672(2005).
RN [2] {ECO:0000313|EMBL:AGF36994.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ROC2010 {ECO:0000313|EMBL:AGF36994.1};
RX PubMed=23400570; DOI=10.4269/ajtmh.12-0758;
RA Reynolds M.G., Emerson G.L., Pukuta E., Karhemere S., Muyembe J.J.,
RA Bikindou A., McCollum A.M., Moses C., Wilkins K., Zhao H., Damon I.K.,
RA Karem K.L., Li Y., Carroll D.S., Mombouli J.V.;
RT "Detection of human monkeypox in the republic of the congo following
RT intensive community education.";
RL Am. J. Trop. Med. Hyg. 88:982-985(2013).
RN [3] {ECO:0000313|Proteomes:UP000099021, ECO:0000313|Proteomes:UP000121251}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DRC Yandongi 1985 {ECO:0000313|EMBL:AGF36853.1}, and Sudan
RC 2005_01 {ECO:0000313|EMBL:AGF36646.1};
RX PubMed=23347770; DOI=10.3201/eid1902.121220;
RA Nakazawa Y., Emerson G.L., Carroll D.S., Zhao H., Li Y., Reynolds M.G.,
RA Karem K.L., Olson V.A., Lash R.R., Davidson W.B., Smith S.K., Levine R.S.,
RA Regnery R.L., Sammons S.A., Frace M.A., Mutasim E.M., Karsani M.E.,
RA Muntasir M.O., Babiker A.A., Opoka L., Chowdhary V., Damon I.K.;
RT "Phylogenetic and ecologic perspectives of a monkeypox outbreak, southern
RT Sudan, 2005.";
RL Emerg. Infect. Dis. 19:237-245(2013).
RN [4] {ECO:0000313|Proteomes:UP000112333, ECO:0000313|Proteomes:UP000113810}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DRC 06-0950 {ECO:0000313|EMBL:AGR34451.1}, DRC 06-0970
RC {ECO:0000313|EMBL:AGR34641.1}, DRC 06-0999
RC {ECO:0000313|EMBL:AGR34832.1}, DRC 06-1070
RC {ECO:0000313|EMBL:AGR35023.1}, DRC 06-1075
RC {ECO:0000313|EMBL:AGR35214.1}, DRC 06-1076
RC {ECO:0000313|EMBL:AGR35405.1}, DRC 07-0045
RC {ECO:0000313|EMBL:AGR35596.1}, DRC 07-0046
RC {ECO:0000313|EMBL:AGR35787.1}, DRC 07-0092
RC {ECO:0000313|EMBL:AGR35978.1}, DRC 07-0093
RC {ECO:0000313|EMBL:AGR36169.1}, DRC 07-0104
RC {ECO:0000313|EMBL:AGR36360.1}, DRC 07-0120
RC {ECO:0000313|EMBL:AGR36551.1}, DRC 07-0275
RC {ECO:0000313|EMBL:AGR36742.1}, DRC 07-0283
RC {ECO:0000313|EMBL:AGR36933.1}, DRC 07-0286
RC {ECO:0000313|EMBL:AGR37124.1}, DRC 07-0287
RC {ECO:0000313|EMBL:AGR37315.1}, DRC 07-0337
RC {ECO:0000313|EMBL:AGR37506.1}, DRC 07-0338
RC {ECO:0000313|EMBL:AGR37696.1}, DRC 07-0354
RC {ECO:0000313|EMBL:AGR37886.1}, DRC 07-0450
RC {ECO:0000313|EMBL:AGR38076.1}, DRC 07-0480
RC {ECO:0000313|EMBL:AGR38267.1}, DRC 07-0514
RC {ECO:0000313|EMBL:AGR38458.1}, and DRC 07-0662
RC {ECO:0000313|EMBL:AGR38649.1};
RX PubMed=24457084; DOI=10.3201/eid2002.130118;
RA Kugelman J.R., Johnston S.C., Mulembakani P.M., Kisalu N., Lee M.S.,
RA Koroleva G., McCarthy S.E., Gestole M.C., Wolfe N.D., Fair J.N.,
RA Schneider B.S., Wright L.L., Huggins J., Whitehouse C.A., Wemakoy E.O.,
RA Muyembe-Tamfum J.J., Hensley L.E., Palacios G.F., Rimoin A.W.;
RT "Genomic variability of monkeypox virus among humans, Democratic Republic
RT of the Congo.";
RL Emerg. Infect. Dis. 20:232-239(2014).
RN [5] {ECO:0000313|Proteomes:UP000102730, ECO:0000313|Proteomes:UP000138604}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Boende_DRC_2008 {ECO:0000313|EMBL:AKG51065.1}, Cameroon-1990
RC {ECO:0000313|EMBL:AIE41232.1}, Congo_8 {ECO:0000313|EMBL:AIE40353.1},
RC Gabon-1988 {ECO:0000313|EMBL:AIE41410.1}, Ikubi
RC {ECO:0000313|EMBL:AIE40175.1}, and Yambuku_DRC_1985
RC {ECO:0000313|EMBL:AKG51438.1};
RX PubMed=25912718; DOI=10.3390/v7042168;
RA Nakazawa Y., Mauldin M.R., Emerson G.L., Reynolds M.G., Lash R.R., Gao J.,
RA Zhao H., Li Y., Muyembe J.J., Kingebeni P.M., Wemakoy O., Malekani J.,
RA Karem K.L., Damon I.K., Carroll D.S.;
RT "A phylogeographic investigation of african monkeypox.";
RL Viruses 7:2168-2184(2015).
RN [6] {ECO:0000313|EMBL:AKS47996.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MPX0297 {ECO:0000313|EMBL:AKS47996.1}, MPX0338
RC {ECO:0000313|EMBL:AKS47997.1}, and MPX0420
RC {ECO:0000313|EMBL:AKS47998.1};
RA Mccollum A.M., Nakazawa Y., Ndongala G.M., Pukuta E., Karhemere S.,
RA Muyembe J.-J., Lushima R.S., Ilunga B.K., Kabamba J., Wilkins K., Gao J.,
RA Li Y., Damon I.K., Carroll D.S., Malekani J., Reynolds M.G.;
RT "Human monkeypox in the Kivus, a former conflict region of The Democratic
RT Republic of the Congo.";
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:AKG51065.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Boende_DRC_2008 {ECO:0000313|EMBL:AKG51065.1}, and
RC Yambuku_DRC_1985 {ECO:0000313|EMBL:AKG51438.1};
RA Yoshinori N., Mauldin M.R., Emerson G.L., Reynolds M.G., Lash R.R., Gao J.,
RA Zhao H., Li Y., Muyembe J.-J., Kingbeni P.M., Wemakoy O., Malekani J.,
RA Karem K.L., Damon I.K., Carroll D.S.;
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|Proteomes:UP000515822, ECO:0000313|Proteomes:UP000515831}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=015c_contig_SPADES {ECO:0000313|EMBL:QNI39575.1,
RC ECO:0000313|Proteomes:UP000515962}, 18_contig_SPADES
RC {ECO:0000313|EMBL:QNI39397.1, ECO:0000313|Proteomes:UP000515988},
RC 38c_contig_SPADES {ECO:0000313|EMBL:QNI39210.1,
RC ECO:0000313|Proteomes:UP000515831}, A1_contig_SPADES
RC {ECO:0000313|EMBL:QNI40512.1, ECO:0000313|Proteomes:UP000515912},
RC A2_contig_SPADES {ECO:0000313|EMBL:QNI40329.1,
RC ECO:0000313|Proteomes:UP000515894}, A4_contig_SPADES
RC {ECO:0000313|EMBL:QNI39027.1, ECO:0000313|Proteomes:UP000515952},
RC A5_contig_SPADES {ECO:0000313|EMBL:QNI38857.1,
RC ECO:0000313|Proteomes:UP000515822}, A6_contig_SPADES
RC {ECO:0000313|EMBL:QNI40138.1, ECO:0000313|Proteomes:UP000515921},
RC B1_contig_SPADES {ECO:0000313|EMBL:QNI39947.1,
RC ECO:0000313|Proteomes:UP000515833}, and B2_contig_SPADES
RC {ECO:0000313|EMBL:QNI39757.1, ECO:0000313|Proteomes:UP000515953};
RA Nkili Meyong A.;
RL Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
RN [9] {ECO:0000313|Proteomes:UP000515822, ECO:0000313|Proteomes:UP000515831}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=015c_contig_SPADES {ECO:0000313|EMBL:QNI39575.1,
RC ECO:0000313|Proteomes:UP000515962}, 18_contig_SPADES
RC {ECO:0000313|EMBL:QNI39397.1, ECO:0000313|Proteomes:UP000515988},
RC 38c_contig_SPADES {ECO:0000313|EMBL:QNI39210.1,
RC ECO:0000313|Proteomes:UP000515831}, A1_contig_SPADES
RC {ECO:0000313|EMBL:QNI40512.1, ECO:0000313|Proteomes:UP000515912},
RC A2_contig_SPADES {ECO:0000313|EMBL:QNI40329.1,
RC ECO:0000313|Proteomes:UP000515894}, A4_contig_SPADES
RC {ECO:0000313|EMBL:QNI39027.1, ECO:0000313|Proteomes:UP000515952},
RC A5_contig_SPADES {ECO:0000313|EMBL:QNI38857.1,
RC ECO:0000313|Proteomes:UP000515822}, A6_contig_SPADES
RC {ECO:0000313|EMBL:QNI40138.1, ECO:0000313|Proteomes:UP000515921},
RC B1_contig_SPADES {ECO:0000313|EMBL:QNI39947.1,
RC ECO:0000313|Proteomes:UP000515833}, and B2_contig_SPADES
RC {ECO:0000313|EMBL:QNI39757.1, ECO:0000313|Proteomes:UP000515953};
RA Selekon B., Labouba I.L., Gonofio E.C., Sem Ouilibona R., Simo Tchetgna H.,
RA Besombes C., Feher M., Fontanet A., Kazanji M., Manugerra J.-C.,
RA Gessain A., Nakoune E., Berthet N.;
RT "Genomic history of human monkeypox in the Central African Republic between
RT 2001 and 2018.";
RL Submitted (SEP-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.6; Evidence={ECO:0000256|ARBA:ARBA00024550};
CC -!- SIMILARITY: Belongs to the poxviridae DNA-directed RNA polymerase 147
CC kDa subunit family. {ECO:0000256|ARBA:ARBA00006884}.
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DR EMBL; DQ011154; AAY97089.1; -; Genomic_DNA.
DR EMBL; DQ011155; AAY97290.1; -; Genomic_DNA.
DR EMBL; KC257459; AGF36646.1; -; Genomic_DNA.
DR EMBL; KC257460; AGF36853.1; -; Genomic_DNA.
DR EMBL; KC257461; AGF36994.1; -; Genomic_DNA.
DR EMBL; JX878407; AGR34451.1; -; Genomic_DNA.
DR EMBL; JX878408; AGR34641.1; -; Genomic_DNA.
DR EMBL; JX878409; AGR34832.1; -; Genomic_DNA.
DR EMBL; JX878410; AGR35023.1; -; Genomic_DNA.
DR EMBL; JX878411; AGR35214.1; -; Genomic_DNA.
DR EMBL; JX878412; AGR35405.1; -; Genomic_DNA.
DR EMBL; JX878413; AGR35596.1; -; Genomic_DNA.
DR EMBL; JX878414; AGR35787.1; -; Genomic_DNA.
DR EMBL; JX878415; AGR35978.1; -; Genomic_DNA.
DR EMBL; JX878416; AGR36169.1; -; Genomic_DNA.
DR EMBL; JX878417; AGR36360.1; -; Genomic_DNA.
DR EMBL; JX878418; AGR36551.1; -; Genomic_DNA.
DR EMBL; JX878419; AGR36742.1; -; Genomic_DNA.
DR EMBL; JX878420; AGR36933.1; -; Genomic_DNA.
DR EMBL; JX878421; AGR37124.1; -; Genomic_DNA.
DR EMBL; JX878422; AGR37315.1; -; Genomic_DNA.
DR EMBL; JX878423; AGR37506.1; -; Genomic_DNA.
DR EMBL; JX878424; AGR37696.1; -; Genomic_DNA.
DR EMBL; JX878425; AGR37886.1; -; Genomic_DNA.
DR EMBL; JX878426; AGR38076.1; -; Genomic_DNA.
DR EMBL; JX878427; AGR38267.1; -; Genomic_DNA.
DR EMBL; JX878428; AGR38458.1; -; Genomic_DNA.
DR EMBL; JX878429; AGR38649.1; -; Genomic_DNA.
DR EMBL; KJ642612; AIE40175.1; -; Genomic_DNA.
DR EMBL; KJ642613; AIE40353.1; -; Genomic_DNA.
DR EMBL; KJ642618; AIE41232.1; -; Genomic_DNA.
DR EMBL; KJ642619; AIE41410.1; -; Genomic_DNA.
DR EMBL; KP849469; AKG51065.1; -; Genomic_DNA.
DR EMBL; KP849471; AKG51438.1; -; Genomic_DNA.
DR EMBL; KP739438; AKS47996.1; -; Genomic_DNA.
DR EMBL; KP739443; AKS47997.1; -; Genomic_DNA.
DR EMBL; KP739448; AKS47998.1; -; Genomic_DNA.
DR EMBL; MN702444; QNI38857.1; -; Genomic_DNA.
DR EMBL; MN702445; QNI39027.1; -; Genomic_DNA.
DR EMBL; MN702446; QNI39210.1; -; Genomic_DNA.
DR EMBL; MN702447; QNI39397.1; -; Genomic_DNA.
DR EMBL; MN702448; QNI39575.1; -; Genomic_DNA.
DR EMBL; MN702449; QNI39757.1; -; Genomic_DNA.
DR EMBL; MN702450; QNI39947.1; -; Genomic_DNA.
DR EMBL; MN702451; QNI40138.1; -; Genomic_DNA.
DR EMBL; MN702452; QNI40329.1; -; Genomic_DNA.
DR EMBL; MN702453; QNI40512.1; -; Genomic_DNA.
DR SMR; Q3I8S4; -.
DR Proteomes; UP000099021; Genome.
DR Proteomes; UP000099051; Genome.
DR Proteomes; UP000100082; Genome.
DR Proteomes; UP000102730; Genome.
DR Proteomes; UP000112333; Genome.
DR Proteomes; UP000113810; Genome.
DR Proteomes; UP000114038; Genome.
DR Proteomes; UP000116946; Genome.
DR Proteomes; UP000117231; Genome.
DR Proteomes; UP000118284; Genome.
DR Proteomes; UP000121251; Genome.
DR Proteomes; UP000124163; Genome.
DR Proteomes; UP000126777; Genome.
DR Proteomes; UP000130227; Genome.
DR Proteomes; UP000138604; Genome.
DR Proteomes; UP000140016; Genome.
DR Proteomes; UP000143488; Genome.
DR Proteomes; UP000143786; Genome.
DR Proteomes; UP000148165; Genome.
DR Proteomes; UP000150530; Genome.
DR Proteomes; UP000150603; Genome.
DR Proteomes; UP000151120; Genome.
DR Proteomes; UP000151462; Genome.
DR Proteomes; UP000153264; Genome.
DR Proteomes; UP000153809; Genome.
DR Proteomes; UP000155574; Genome.
DR Proteomes; UP000158033; Genome.
DR Proteomes; UP000164300; Genome.
DR Proteomes; UP000166832; Genome.
DR Proteomes; UP000169092; Genome.
DR Proteomes; UP000170119; Genome.
DR Proteomes; UP000170318; Genome.
DR Proteomes; UP000172279; Genome.
DR Proteomes; UP000515822; Contig_spades genomic sequence.
DR Proteomes; UP000515831; Contig_spades genomic sequence.
DR Proteomes; UP000515833; Contig_spades genomic sequence.
DR Proteomes; UP000515894; Contig_spades genomic sequence.
DR Proteomes; UP000515912; Contig_spades genomic sequence.
DR Proteomes; UP000515921; Contig_spades genomic sequence.
DR Proteomes; UP000515952; Contig_spades genomic sequence.
DR Proteomes; UP000515953; Contig_spades genomic sequence.
DR Proteomes; UP000515962; Contig_spades genomic sequence.
DR Proteomes; UP000515988; Contig_spades genomic sequence.
DR GO; GO:0000428; C:DNA-directed RNA polymerase complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003899; F:DNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR Gene3D; 1.10.132.30; -; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 6.10.250.2940; -; 1.
DR Gene3D; 3.30.1490.180; RNA polymerase ii; 1.
DR Gene3D; 4.10.860.120; RNA polymerase II, clamp domain; 1.
DR InterPro; IPR045867; DNA-dir_RpoC_beta_prime.
DR InterPro; IPR000722; RNA_pol_asu.
DR InterPro; IPR006592; RNA_pol_N.
DR InterPro; IPR007080; RNA_pol_Rpb1_1.
DR InterPro; IPR007066; RNA_pol_Rpb1_3.
DR InterPro; IPR007083; RNA_pol_Rpb1_4.
DR InterPro; IPR007081; RNA_pol_Rpb1_5.
DR InterPro; IPR044893; RNA_pol_Rpb1_clamp_domain.
DR InterPro; IPR038120; Rpb1_funnel_sf.
DR PANTHER; PTHR19376; DNA-DIRECTED RNA POLYMERASE; 1.
DR PANTHER; PTHR19376:SF37; DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1; 1.
DR Pfam; PF04997; RNA_pol_Rpb1_1; 1.
DR Pfam; PF00623; RNA_pol_Rpb1_2; 1.
DR Pfam; PF04983; RNA_pol_Rpb1_3; 1.
DR Pfam; PF05000; RNA_pol_Rpb1_4; 1.
DR Pfam; PF04998; RNA_pol_Rpb1_5; 1.
DR SMART; SM00663; RPOLA_N; 1.
DR SUPFAM; SSF64484; beta and beta-prime subunits of DNA dependent RNA-polymerase; 1.
PE 3: Inferred from homology;
KW DNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022478};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 188..469
FT /note="RNA polymerase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00663"
SQ SEQUENCE 1286 AA; 146814 MW; DE4497A42D1B729C CRC64;
MAVISKVTYS LYDQKEINAT DIIISHIKND DDIGTVKDGR LGAMDGALCK TCGKTELECF
GHWGKVSIYK THIVKPEFIS EIIRLLNHIC IHCGLLRSRE PYSDDINLKE LSGHALRRLK
DKILSKKKSC WNSECMQPYQ KITFSKKKVC FVNKLDDINV PNSLIYQKLI SIHEKFWPLL
EIHQYPANLF YTDYFPIPPL IIRPAISFWI DSIPKETNEL TYLLGMIVKN CNLNADEQVI
QKAVIEYDDI KIISNNTTSI NLSYITSGKN NMIRSYIVAR RKDQTARSVI GPSTSITVNE
VGMPTYIRNT LTEKIFVNAF TVDKVKQLLA SNQVKFYFNK RLNQLTRIRQ GKFIKNKIHL
LPGDWVEVAV QEYTSIIFGR QPSLHRYNVI ASSIRATEGD TIKISPGIAN SQNADFDGDE
EWMILEQNPK AVVEQSILMY PTTLLKHDIH GAPVYGSIQD EIVAAYSLFR IQDLCLDEVL
NILGKYGREF DPKGKCKFSG KDIYTYLIGE KINYPGLLKD GEIIANDVDS NFVVAMRHLS
LAGLLSDHKS NVEGINFIIK SSYVFKRYLS IYGFGVTFKD LRPNSTFTNK LEAINVEKIE
LIKEAYAKYL KDVRDGKIVP LSKALEADYL ESMLSNLTNL NIREIEEHMR QTLIDDPDNN
LLKMAKAGYK VNPTELMYIL GTYGQQRIDG EPAETRVLGR VLPYYLPDSK DPEGRGYILN
SLTKGLTGSQ YYFSMLVARS QSTDIVCETS RTGTLARKII KKMEDMVVDG YGQVVIGNTL
IKYAANYTKI LGSVCKPVDL IYPDESMTWY LEISALWNKI KQGFVYSQKQ KLAKKTLAPF
NFLVFVKPTT EDNAIKVKDL YDMIHNVIDD VREKYFFTVS NIDFMEYIFL THLNPSRIRI
TKETAITIFE KFYEKLNYTL GGGTPIGIIS AQVLSEKFTQ QALSSFHTTE KSGAVKQKLG
FNEFNNLTNL SKNKTEIITL VSDDISKLQS VKINFEFVCL GELNPDITLR KETDRYVVDI
IVNRLYIKRA EITELVVEYM IERFISFSVI VKEWGMETFI EDEDNIRFTV YLNFVEPEEL
NLSKFMMVLP GAANKGKISK FKIPISDYTG YNDFNQTKKL NKMTVELMNL KELGSFDLEN
VNVYPGVWNT YDIFGIEAAR GYLCEAMLNT YGEGFDYLYQ PCDLLASLLC ASYEPESVNK
FKFGAASTLK RATFGDNKAL LNAALHKKSE PINDNSSCHF FSKVPNIGTG YYKYFIDLGL
LMRMERKLSD KISSQKIKEI EETEDF
//
