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Database: UniProt
Entry: Q3LUG2_ACIBA
LinkDB: Q3LUG2_ACIBA
Original site: Q3LUG2_ACIBA 
ID   Q3LUG2_ACIBA            Unreviewed;       262 AA.
AC   Q3LUG2;
DT   25-OCT-2005, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2005, sequence version 1.
DT   24-JAN-2024, entry version 86.
DE   RecName: Full=Aminoglycoside (3'') (9) adenylyltransferase {ECO:0000256|ARBA:ARBA00035252, ECO:0000256|PIRNR:PIRNR000819};
DE            EC=2.7.7.47 {ECO:0000256|ARBA:ARBA00035126, ECO:0000256|PIRNR:PIRNR000819};
GN   Name=aadA1 {ECO:0000313|EMBL:ABA08389.1};
GN   ORFNames=EGM95_00465 {ECO:0000313|EMBL:AYY87353.1}, EGM95_08060
GN   {ECO:0000313|EMBL:AYY88723.1}, EGM95_09400
GN   {ECO:0000313|EMBL:AYY88970.1}, OMP06_18635
GN   {ECO:0000313|EMBL:WCS70143.1};
OS   Acinetobacter baumannii.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC   Acinetobacter; Acinetobacter calcoaceticus/baumannii complex.
OX   NCBI_TaxID=470 {ECO:0000313|EMBL:ABA08389.1};
RN   [1] {ECO:0000313|EMBL:ABA08389.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=AB28 {ECO:0000313|EMBL:ABA08389.1};
RX   PubMed=16304199; DOI=10.1128/AAC.49.12.5179-5181.2005;
RA   Ramirez M.S., Quiroga C., Centron D.;
RT   "Novel rearrangement of a class 2 integron in two non-epidemiologically
RT   related isolates of Acinetobacter baumannii.";
RL   Antimicrob. Agents Chemother. 49:5179-5181(2005).
RN   [2] {ECO:0000313|EMBL:ABA08401.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=AB300 {ECO:0000313|EMBL:ABA08401.1};
RA   Ramirez M.S., Quiroga C., Centron D.;
RT   "Tn7 transposon in a multiresistant isolate of Acinetobacter baumanii.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:ACN89663.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=A101 {ECO:0000313|EMBL:ACN89663.1};
RX   PubMed=19917745; DOI=10.1128/AAC.01392-08;
RG   Argentinian Integron Study Group;
RA   Ramirez M.S., Pineiro S., Centron D.;
RT   "Novel insights about class 2 integrons from experimental and genomic
RT   epidemiology.";
RL   Antimicrob. Agents Chemother. 54:699-706(2010).
RN   [4] {ECO:0000313|EMBL:AIL25535.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=M3AC9-7 {ECO:0000313|EMBL:AIL25535.1};
RX   PubMed=25246647;
RA   Martinez T., Vazquez G.J., Aquino E.E., Martinez I., Robledo I.E.;
RT   "ISEcp1-Mediated Transposition of blaKPC into the Chromosome of a Clinical
RT   Isolate of Acinetobacter baumannii from Puerto Rico.";
RL   J. Med. Microbiol. 0:0-0(2014).
RN   [5] {ECO:0000313|EMBL:AIL25535.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=M3AC9-7 {ECO:0000313|EMBL:AIL25535.1};
RA   Teresa M., Robledo I.E., Vazquez G.J., Aquino E.E., Martinez I.;
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:AIO08839.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=B-389/14 {ECO:0000313|EMBL:AIO08839.1};
RA   Astashkin E.I., Knyazeva A.I., Kartsev N.N., Fursova N.K.;
RL   Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:AYY87353.1, ECO:0000313|Proteomes:UP000273577}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MRSN15313 {ECO:0000313|EMBL:AYY87353.1,
RC   ECO:0000313|Proteomes:UP000273577};
RA   Sorenson N.M., Snesrud E., Xavier D.E., Cacci L.C., Oeleman W.,
RA   Iavarone A.T., Mc Gann P., Riley L.W., Moreira B.M.;
RT   "A novel plasmid carries a functional mcr-4.3 gene in a colistin-resistant
RT   Acinetobacter baumannii clinical strain.";
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|EMBL:WCS70143.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=RBH2 {ECO:0000313|EMBL:WCS70143.1};
RA   Ambrose S.J., Hall R.M.;
RT   "Acinetobacter baumannii RBH2 complete genome.";
RL   Submitted (FEB-2023) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + spectinomycin = 9-O-adenylylspectinomycin + diphosphate;
CC         Xref=Rhea:RHEA:63228, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:146260, ChEBI:CHEBI:146261;
CC         Evidence={ECO:0000256|ARBA:ARBA00001672,
CC         ECO:0000256|PIRNR:PIRNR000819};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + streptomycin = 3''-O-adenylylstreptomycin + diphosphate;
CC         Xref=Rhea:RHEA:20245, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:58007, ChEBI:CHEBI:58605; EC=2.7.7.47;
CC         Evidence={ECO:0000256|ARBA:ARBA00035070,
CC         ECO:0000256|PIRNR:PIRNR000819};
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DR   EMBL; DQ176450; ABA08389.1; -; Genomic_DNA.
DR   EMBL; DQ176451; ABA08401.1; -; Genomic_DNA.
DR   EMBL; FJ785525; ACN89663.1; -; Genomic_DNA.
DR   EMBL; KJ748372; AIL25535.1; -; Genomic_DNA.
DR   EMBL; KM009107; AIO08839.1; -; Genomic_DNA.
DR   EMBL; CP033869; AYY87353.1; -; Genomic_DNA.
DR   EMBL; CP033869; AYY88723.1; -; Genomic_DNA.
DR   EMBL; CP033869; AYY88970.1; -; Genomic_DNA.
DR   EMBL; CP110462; WCS70143.1; -; Genomic_DNA.
DR   RefSeq; WP_001206315.1; NZ_NRII01000137.1.
DR   GeneID; 79875491; -.
DR   Proteomes; UP000273577; Chromosome.
DR   Proteomes; UP001156386; Chromosome.
DR   GO; GO:0070566; F:adenylyltransferase activity; IEA:InterPro.
DR   GO; GO:0009012; F:aminoglycoside 3''-adenylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   CDD; cd05403; NT_KNTase_like; 1.
DR   Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR   InterPro; IPR024172; AadA/Aad9.
DR   InterPro; IPR025184; AadA_C.
DR   InterPro; IPR043519; NT_sf.
DR   InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR   Pfam; PF13427; AadA_C; 1.
DR   Pfam; PF01909; NTP_transf_2; 1.
DR   PIRSF; PIRSF000819; Streptomycin_3-adenylyltransf; 1.
DR   SUPFAM; SSF81301; Nucleotidyltransferase; 1.
PE   4: Predicted;
KW   Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251,
KW   ECO:0000256|PIRNR:PIRNR000819};
KW   ATP-binding {ECO:0000256|PIRNR:PIRNR000819};
KW   Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000819};
KW   Nucleotidyltransferase {ECO:0000256|PIRNR:PIRNR000819,
KW   ECO:0000313|EMBL:AIL25535.1};
KW   Transferase {ECO:0000256|PIRNR:PIRNR000819, ECO:0000313|EMBL:ABA08389.1}.
FT   DOMAIN          28..76
FT                   /note="Polymerase nucleotidyl transferase"
FT                   /evidence="ECO:0000259|Pfam:PF01909"
FT   DOMAIN          152..253
FT                   /note="Adenylyltransferase AadA C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13427"
SQ   SEQUENCE   262 AA;  29203 MW;  A2EEB1DBA6272F33 CRC64;
     MREAVIAEVS TQLSEVVGVI ERHLEPTLLA VHLYGSAVDG GLKPHSDIDL LVTVTVRLDE
     TTRRALINDL LETSASPGES EILRAVEVTI VVHDDIIPWR YPAKRELQFG EWQRNDILAG
     IFEPATIDID LAILLTKARE HSVALVGPAA EELFDPVPEQ DLFEALNETL TLWNSPPDWA
     GDERNVVLTL SRIWYSAVTG KIAPKDVAAD WAMERLPAQY QPVILEARQA YLGQEDRLAS
     RADQLEEFVH YVKGEITKVV GK
//
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