ID Q3LUG2_ACIBA Unreviewed; 262 AA.
AC Q3LUG2;
DT 25-OCT-2005, integrated into UniProtKB/TrEMBL.
DT 25-OCT-2005, sequence version 1.
DT 24-JAN-2024, entry version 86.
DE RecName: Full=Aminoglycoside (3'') (9) adenylyltransferase {ECO:0000256|ARBA:ARBA00035252, ECO:0000256|PIRNR:PIRNR000819};
DE EC=2.7.7.47 {ECO:0000256|ARBA:ARBA00035126, ECO:0000256|PIRNR:PIRNR000819};
GN Name=aadA1 {ECO:0000313|EMBL:ABA08389.1};
GN ORFNames=EGM95_00465 {ECO:0000313|EMBL:AYY87353.1}, EGM95_08060
GN {ECO:0000313|EMBL:AYY88723.1}, EGM95_09400
GN {ECO:0000313|EMBL:AYY88970.1}, OMP06_18635
GN {ECO:0000313|EMBL:WCS70143.1};
OS Acinetobacter baumannii.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Acinetobacter; Acinetobacter calcoaceticus/baumannii complex.
OX NCBI_TaxID=470 {ECO:0000313|EMBL:ABA08389.1};
RN [1] {ECO:0000313|EMBL:ABA08389.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB28 {ECO:0000313|EMBL:ABA08389.1};
RX PubMed=16304199; DOI=10.1128/AAC.49.12.5179-5181.2005;
RA Ramirez M.S., Quiroga C., Centron D.;
RT "Novel rearrangement of a class 2 integron in two non-epidemiologically
RT related isolates of Acinetobacter baumannii.";
RL Antimicrob. Agents Chemother. 49:5179-5181(2005).
RN [2] {ECO:0000313|EMBL:ABA08401.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB300 {ECO:0000313|EMBL:ABA08401.1};
RA Ramirez M.S., Quiroga C., Centron D.;
RT "Tn7 transposon in a multiresistant isolate of Acinetobacter baumanii.";
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ACN89663.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A101 {ECO:0000313|EMBL:ACN89663.1};
RX PubMed=19917745; DOI=10.1128/AAC.01392-08;
RG Argentinian Integron Study Group;
RA Ramirez M.S., Pineiro S., Centron D.;
RT "Novel insights about class 2 integrons from experimental and genomic
RT epidemiology.";
RL Antimicrob. Agents Chemother. 54:699-706(2010).
RN [4] {ECO:0000313|EMBL:AIL25535.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=M3AC9-7 {ECO:0000313|EMBL:AIL25535.1};
RX PubMed=25246647;
RA Martinez T., Vazquez G.J., Aquino E.E., Martinez I., Robledo I.E.;
RT "ISEcp1-Mediated Transposition of blaKPC into the Chromosome of a Clinical
RT Isolate of Acinetobacter baumannii from Puerto Rico.";
RL J. Med. Microbiol. 0:0-0(2014).
RN [5] {ECO:0000313|EMBL:AIL25535.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=M3AC9-7 {ECO:0000313|EMBL:AIL25535.1};
RA Teresa M., Robledo I.E., Vazquez G.J., Aquino E.E., Martinez I.;
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:AIO08839.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=B-389/14 {ECO:0000313|EMBL:AIO08839.1};
RA Astashkin E.I., Knyazeva A.I., Kartsev N.N., Fursova N.K.;
RL Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:AYY87353.1, ECO:0000313|Proteomes:UP000273577}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MRSN15313 {ECO:0000313|EMBL:AYY87353.1,
RC ECO:0000313|Proteomes:UP000273577};
RA Sorenson N.M., Snesrud E., Xavier D.E., Cacci L.C., Oeleman W.,
RA Iavarone A.T., Mc Gann P., Riley L.W., Moreira B.M.;
RT "A novel plasmid carries a functional mcr-4.3 gene in a colistin-resistant
RT Acinetobacter baumannii clinical strain.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|EMBL:WCS70143.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=RBH2 {ECO:0000313|EMBL:WCS70143.1};
RA Ambrose S.J., Hall R.M.;
RT "Acinetobacter baumannii RBH2 complete genome.";
RL Submitted (FEB-2023) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + spectinomycin = 9-O-adenylylspectinomycin + diphosphate;
CC Xref=Rhea:RHEA:63228, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:146260, ChEBI:CHEBI:146261;
CC Evidence={ECO:0000256|ARBA:ARBA00001672,
CC ECO:0000256|PIRNR:PIRNR000819};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + streptomycin = 3''-O-adenylylstreptomycin + diphosphate;
CC Xref=Rhea:RHEA:20245, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:58007, ChEBI:CHEBI:58605; EC=2.7.7.47;
CC Evidence={ECO:0000256|ARBA:ARBA00035070,
CC ECO:0000256|PIRNR:PIRNR000819};
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DR EMBL; DQ176450; ABA08389.1; -; Genomic_DNA.
DR EMBL; DQ176451; ABA08401.1; -; Genomic_DNA.
DR EMBL; FJ785525; ACN89663.1; -; Genomic_DNA.
DR EMBL; KJ748372; AIL25535.1; -; Genomic_DNA.
DR EMBL; KM009107; AIO08839.1; -; Genomic_DNA.
DR EMBL; CP033869; AYY87353.1; -; Genomic_DNA.
DR EMBL; CP033869; AYY88723.1; -; Genomic_DNA.
DR EMBL; CP033869; AYY88970.1; -; Genomic_DNA.
DR EMBL; CP110462; WCS70143.1; -; Genomic_DNA.
DR RefSeq; WP_001206315.1; NZ_NRII01000137.1.
DR GeneID; 79875491; -.
DR Proteomes; UP000273577; Chromosome.
DR Proteomes; UP001156386; Chromosome.
DR GO; GO:0070566; F:adenylyltransferase activity; IEA:InterPro.
DR GO; GO:0009012; F:aminoglycoside 3''-adenylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR CDD; cd05403; NT_KNTase_like; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR InterPro; IPR024172; AadA/Aad9.
DR InterPro; IPR025184; AadA_C.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR Pfam; PF13427; AadA_C; 1.
DR Pfam; PF01909; NTP_transf_2; 1.
DR PIRSF; PIRSF000819; Streptomycin_3-adenylyltransf; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251,
KW ECO:0000256|PIRNR:PIRNR000819};
KW ATP-binding {ECO:0000256|PIRNR:PIRNR000819};
KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000819};
KW Nucleotidyltransferase {ECO:0000256|PIRNR:PIRNR000819,
KW ECO:0000313|EMBL:AIL25535.1};
KW Transferase {ECO:0000256|PIRNR:PIRNR000819, ECO:0000313|EMBL:ABA08389.1}.
FT DOMAIN 28..76
FT /note="Polymerase nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF01909"
FT DOMAIN 152..253
FT /note="Adenylyltransferase AadA C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13427"
SQ SEQUENCE 262 AA; 29203 MW; A2EEB1DBA6272F33 CRC64;
MREAVIAEVS TQLSEVVGVI ERHLEPTLLA VHLYGSAVDG GLKPHSDIDL LVTVTVRLDE
TTRRALINDL LETSASPGES EILRAVEVTI VVHDDIIPWR YPAKRELQFG EWQRNDILAG
IFEPATIDID LAILLTKARE HSVALVGPAA EELFDPVPEQ DLFEALNETL TLWNSPPDWA
GDERNVVLTL SRIWYSAVTG KIAPKDVAAD WAMERLPAQY QPVILEARQA YLGQEDRLAS
RADQLEEFVH YVKGEITKVV GK
//