ID Q3S3D7_XENBO Unreviewed; 1441 AA.
AC Q3S3D7;
DT 11-OCT-2005, integrated into UniProtKB/TrEMBL.
DT 11-OCT-2005, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Neogenin variant 1 {ECO:0000313|EMBL:ABA02169.1};
OS Xenopus borealis (Kenyan clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8354 {ECO:0000313|EMBL:ABA02169.1};
RN [1] {ECO:0000313|EMBL:ABA02169.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16836993; DOI=10.1016/j.ydbio.2006.06.018;
RA Wilson N.H., Key B.;
RT "Neogenin interacts with RGMa and netrin-1 to guide axons within the
RT embryonic vertebrate forebrain.";
RL Dev. Biol. 296:485-498(2006).
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. DCC family.
CC {ECO:0000256|ARBA:ARBA00009588}.
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DR EMBL; DQ173198; ABA02169.1; -; mRNA.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008046; F:axon guidance receptor activity; IMP:UniProtKB.
DR GO; GO:0007411; P:axon guidance; IMP:UniProtKB.
DR GO; GO:0030900; P:forebrain development; IMP:UniProtKB.
DR CDD; cd00063; FN3; 6.
DR CDD; cd00096; Ig; 1.
DR CDD; cd05722; IgI_1_Neogenin_like; 1.
DR CDD; cd05723; IgI_4_Neogenin_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR010560; Neogenin_C.
DR PANTHER; PTHR44170:SF14; NEOGENIN; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF00041; fn3; 6.
DR Pfam; PF07679; I-set; 3.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF06583; Neogenin_C; 1.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 6.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 4.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR PROSITE; PS50853; FN3; 6.
DR PROSITE; PS50835; IG_LIKE; 4.
PE 2: Evidence at transcript level;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..33
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 34..1441
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004228671"
FT TRANSMEM 1105..1128
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 46..141
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 146..232
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 242..330
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 334..420
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 455..548
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 554..644
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 649..743
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 753..847
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 869..965
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 970..1067
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1068..1097
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1133..1228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1281..1337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1075..1097
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1151..1177
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1180..1222
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1292..1309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1441 AA; 156930 MW; 1AB8C990ACBA67D0 CRC64;
MAVRSPPGSI VRVTRGLFAV SILFSVWKKQ TWAANTAGSG FRTFTPFYFL TEPADTVTLR
GFAAVLNCSA YADPTPKIEW KKDGTFLNLV SDDRRRLLPD GSLLITSVVH SKHNKPDEGI
YQCVATVESL GSIVSHTARL SVAGLPRFSS QPESSSVYLG DSIVLNCDVS PELVPFVQWE
QNKAPRELDS RVAILLNGSL VISNANESDA GLYRCAVGGG SSIKYSEEAE IKVLQDTGEE
RPMVFLRQPL PLTRVSGQTA LLTCVVSGYP IPSVRWSHNL KEILNENSEK LTFVAGGNLQ
ISSVTEEDAG IYTCVADNGN QTIQAHAELS IQVPPVFRVK PSNTHAHESR DIVFKCEVTG
KPTPTVKWVK NGDMVIPSDY FKIVEDHDLQ VLGLVRSDEG FYQCIVENEV GNVQAAAQLI
ILEPGVTIPT SPTPSLTRAT AHNVAATPGG PLPSSPRDVV ASLVSTRFIK LTWRMPADPH
GENLIYHVFY SKESMNRERV ENTTRPGEMQ VTIQNLLPET VYYFRVVALN QHGASESSHS
LKVETHPEVQ VPGPAPNFKA TSVSSTSVSV SWETPLSGNG EIQSYKLYYL EKGADNEQDI
DVSGQSYTLN GLKKYTEYTF RVVAFNKHGP GVSTQDVTVR TLSDVPSAAP QNLTLGVRSS
QSILVQWQPP PLGSQNGLIV GYKARYRKTT RKSETSEMLV DAQLSYLFTG LERDTEYSFR
VVALTVNGSG PATDWVSAET FESDLDESRV PDVPSSLHVR PLVTNIVVSW TPPENQHQVV
VRGYAIGYGL GSPHAQTVRV DHKQRYYTID NLDPSSHYVI SLRAFNNVGE GIPLYESAVT
RQHTDPSDVD VFVVHAPYTP VPEPSPMLPP VGVQATILGS DAVRLTWADN SLPKNQKITD
SRYYTVRWKT NIPANTKYKM ANSTTLIYLV TGLKPNTLYE FSVMVTKGRR SSTWSMTAHG
TTFESVPSSP PKDVTVVSKE GKPRTIIVNW QPPSEANGKM TGYIIYYSTD AQAELHDWVI
EPVIGNRLTH QIQELTLDTP YYFKIQARNS KGMGPMSEAV LFRTPKASSI SGKGVRPSDP
GSNSGSTLGG SNSHHGSPTS LDQNMLLTII VSLGVIIVLV AVVIAAICSR RSSSHHKKKR
AASKSVNGSH KYKANSKDVK PPDLWIHHER LELKPTDKSP ETNPILTDTP LPRSPQDLTP
GDSTTEGSIH QHSNSYRGLE SEDSVSSLAA RRGMRPKIMM PFDSQPPQPV VSAHPIHSHD
NSHHFRSVPG FMLHVLGGPP QAAESVRHTP SCDTVVAASS SSQTGPEDPE PSGGSFLPGS
LDEDTVPSVP TAHIRPSHPL KSFAVPAVPT PASGATYEPP LPSSPLLQSQ CPTALSVKTA
SLGTLGRVRP PLSVTVPSAP EPLETTRMLE GSECSYEPDE LSKEMAHLEG LMKDLNAITP
A
//
