ID Q3T3A5_9HIV1 Unreviewed; 335 AA.
AC Q3T3A5;
DT 11-OCT-2005, integrated into UniProtKB/TrEMBL.
DT 11-OCT-2005, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:AAX97023.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AAX97023.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AAX97023.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=01TZ_HS123.4e7 {ECO:0000313|EMBL:AAX97023.1};
RX PubMed=16140747; DOI=10.1128/JVI.79.18.11693-11704.2005;
RA McCutchan F.E., Hoelscher M., Tovanabutra S., Piyasirisilp S.,
RA Sanders-Buell E., Ramos G., Jagodzinski L., Polonis V., Maboko L.,
RA Mmbando D., Hoffmann O., Riedner G., von Sonnenburg F., Robb M., Birx D.L.;
RT "In-depth analysis of a heterosexually acquired human immunodeficiency
RT virus type 1 superinfection: evolution, temporal fluctuation, and
RT intercompartment dynamics from the seronegative window period through 30
RT months postinfection.";
RL J. Virol. 79:11693-11704(2005).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; AY887404; AAX97023.1; -; Genomic_DNA.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR InterPro; IPR000328; GP41-like.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 4: Predicted;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000313|EMBL:AAX97023.1};
KW Virion {ECO:0000313|EMBL:AAX97023.1}.
FT TRANSMEM 157..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 9..196
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAX97023.1"
SQ SEQUENCE 335 AA; 38376 MW; D7A1F15C78B976E8 CRC64;
FLGAAGSTMG TASLTLTVQA RQLLTGIVQQ QSNLLRAIEA QQHLLKLTVW GIKQLQARVL
AVERYLKDQQ LLGIWGCSGK LICTTNVPWN SSWSNKSFND IWDNMTWLQW DKEISNYTEI
IYNLIEESQN QQEKNELDLL ALDKWAGLWN WFDITNWLWY IKIFIMIVGG LIGLRIVFTV
LSIINRVRQG YSPLPFQIHT PNPREPDRLG RIEEEGGEQG RDRSIRLVSG FLALAWDDLR
SLCLFSYHRL RDLILLTARA VELLGRRGWE ALKYLGSLVQ YWGLELKKSA INLLDTIAVV
IAGWTDRVIE IGQGLGRAIL HIPRRIRQGL ETALL
//
