ID Q3T9I0_MOUSE Unreviewed; 733 AA.
AC Q3T9I0;
DT 11-OCT-2005, integrated into UniProtKB/TrEMBL.
DT 11-OCT-2005, sequence version 1.
DT 24-JAN-2024, entry version 86.
DE RecName: Full=HEAT repeat-containing protein 1 {ECO:0000256|RuleBase:RU367065};
DE Flags: Fragment;
GN Name=Heatr1 {ECO:0000313|MGI:MGI:2442524};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAE43040.1};
RN [1] {ECO:0000313|EMBL:BAE43040.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NOD {ECO:0000313|EMBL:BAE43040.1};
RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE43040.1};
RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
RA Carninci P., Hayashizaki Y.;
RT "High-efficiency full-length cDNA cloning.";
RL Methods Enzymol. 303:19-44(1999).
RN [2] {ECO:0000313|EMBL:BAE43040.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NOD {ECO:0000313|EMBL:BAE43040.1};
RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE43040.1};
RX PubMed=11042159; DOI=10.1101/gr.145100;
RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
RT "Normalization and subtraction of cap-trapper-selected cDNAs to prepare
RT full-length cDNA libraries for rapid discovery of new genes.";
RL Genome Res. 10:1617-1630(2000).
RN [3] {ECO:0000313|EMBL:BAE43040.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NOD {ECO:0000313|EMBL:BAE43040.1};
RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE43040.1};
RX PubMed=11076861; DOI=10.1101/gr.152600;
RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N.,
RA Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R.,
RA Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S.,
RA Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y.,
RA Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y.,
RA Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
RT "RIKEN integrated sequence analysis (RISA) system--384-format sequencing
RT pipeline with 384 multicapillary sequencer.";
RL Genome Res. 10:1757-1771(2000).
RN [4] {ECO:0000313|EMBL:BAE43040.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NOD {ECO:0000313|EMBL:BAE43040.1};
RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE43040.1};
RX PubMed=11217851; DOI=10.1038/35055500;
RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
RT "Functional annotation of a full-length mouse cDNA collection.";
RL Nature 409:685-690(2001).
RN [5] {ECO:0000313|EMBL:BAE43040.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NOD {ECO:0000313|EMBL:BAE43040.1};
RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE43040.1};
RX PubMed=12466851; DOI=10.1038/nature01266;
RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
RT "Analysis of the mouse transcriptome based on functional annotation of
RT 60,770 full-length cDNAs.";
RL Nature 420:563-573(2002).
RN [6] {ECO:0000313|EMBL:BAE43040.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NOD {ECO:0000313|EMBL:BAE43040.1};
RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE43040.1};
RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F.,
RA Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M.,
RA Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H., Nomura K.,
RA Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T.,
RA Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.;
RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:BAE43040.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NOD {ECO:0000313|EMBL:BAE43040.1};
RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE43040.1};
RG The FANTOM Consortium;
RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
RT "The Transcriptional Landscape of the Mammalian Genome.";
RL Science 309:1559-1563(2005).
RN [8] {ECO:0000313|EMBL:BAE43040.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NOD {ECO:0000313|EMBL:BAE43040.1};
RC TISSUE=Activated spleen {ECO:0000313|EMBL:BAE43040.1};
RX PubMed=16141073; DOI=10.1126/science.1112009;
RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
RT "Antisense Transcription in the Mammalian Transcriptome.";
RL Science 309:1564-1566(2005).
CC -!- FUNCTION: Involved in nucleolar processing of pre-18S ribosomal RNA.
CC {ECO:0000256|RuleBase:RU367065}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|RuleBase:RU367065}.
CC -!- SIMILARITY: Belongs to the HEATR1/UTP10 family.
CC {ECO:0000256|RuleBase:RU367065}.
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DR EMBL; AK172508; BAE43040.1; -; mRNA.
DR AlphaFoldDB; Q3T9I0; -.
DR PeptideAtlas; Q3T9I0; -.
DR AGR; MGI:2442524; -.
DR MGI; MGI:2442524; Heatr1.
DR ChiTaRS; Heatr1; mouse.
DR GO; GO:0030686; C:90S preribosome; IBA:GO_Central.
DR GO; GO:0001650; C:fibrillar center; ISO:MGI.
DR GO; GO:0005739; C:mitochondrion; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0032040; C:small-subunit processome; ISO:MGI.
DR GO; GO:0034455; C:t-UTP complex; IBA:GO_Central.
DR GO; GO:0030515; F:snoRNA binding; IBA:GO_Central.
DR GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:2000234; P:positive regulation of rRNA processing; ISO:MGI.
DR GO; GO:0045943; P:positive regulation of transcription by RNA polymerase I; ISO:MGI.
DR GO; GO:0042274; P:ribosomal small subunit biogenesis; ISO:MGI.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR022125; U3snoRNP10_N.
DR InterPro; IPR040191; UTP10.
DR PANTHER; PTHR13457; BAP28; 1.
DR PANTHER; PTHR13457:SF1; HEAT REPEAT-CONTAINING PROTEIN 1; 1.
DR Pfam; PF12397; U3snoRNP10; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 2: Evidence at transcript level;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367065};
KW Ribonucleoprotein {ECO:0000256|RuleBase:RU367065};
KW Ribosome biogenesis {ECO:0000256|RuleBase:RU367065};
KW rRNA processing {ECO:0000256|RuleBase:RU367065}.
FT DOMAIN 238..354
FT /note="U3 small nucleolar RNA-associated protein 10 N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12397"
FT NON_TER 733
FT /evidence="ECO:0000313|EMBL:BAE43040.1"
SQ SEQUENCE 733 AA; 81969 MW; 4B993E2D81CF30FD CRC64;
MTSLAQQLQR LALPQTDPSL LSRREVASLL FDPKEAATID RDTAFAIGCT GLEELLGIDP
AFEQFEAPLF SQLAKGLERS VQTKAVNKQL DENISSFLLH LSPYFLLKPA QKCLEWLIHR
FHIHLYNADS LIACVLPYHE TRVFVRVIQL LKISNPKHKW FWLSPVKHSG VPLARGTLVT
HCYKDLGFMD FICSLVTRSV KAFAEDPGSS TRLRVLLAFY ASTIVSALVA AENLSDNVVT
KLFPYIQKGL KSSLPDYRAA TYMIICQISV KVTMEDTFVK SLASQLIKTL TKVPSQVNDG
LGCLIILLQR QKPENLGEKP FLHLCGVPDL IGLLHGISES YDVSPLLRCM LPHLVASVVQ
HIAGEEAEGI DGQIYKNHLE EILIKIPLTN NLDHLLASHL FEEYISYSSQ EETQANGVAL
LNEQFLPLIR LLESKYPRAL DAVLEEHLKE ITGLKKQELF HQFISLSTSG GKYQFLEDSD
TSLMLSLNHP LAPVRLLAVN HLKTFMKTSK EGIDETFIKE AILTRLGDDN VDVVLATLSA
FEIFQQHFGV EETVSSLLNL FQRADLSKNE GWFRVLELAA NILIKEEILS KNDQLANQVV
VQLLPFMVIT SNDIESPDMK IAIHLSKSGI CSLHPLLRGW KEALENVIKS RKSREIIGVG
NQKMVQLLGS NLSLGERSTV LKLVEDLVCA GEKESYSLKQ KVAFHVTVSV LISCCSSFQE
TCFPFALRVF SLL
//
