ID Q3TRH0_MOUSE Unreviewed; 838 AA.
AC Q3TRH0;
DT 11-OCT-2005, integrated into UniProtKB/TrEMBL.
DT 11-OCT-2005, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE RecName: Full=Trinucleotide repeat-containing gene 6B protein {ECO:0008006|Google:ProtNLM};
GN Name=Tnrc6b {ECO:0000313|MGI:MGI:2443730};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAE37059.1};
RN [1] {ECO:0000313|EMBL:BAE37059.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE37059.1};
RC TISSUE=Thymus {ECO:0000313|EMBL:BAE37059.1};
RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
RA Carninci P., Hayashizaki Y.;
RT "High-efficiency full-length cDNA cloning.";
RL Methods Enzymol. 303:19-44(1999).
RN [2] {ECO:0000313|EMBL:BAE37059.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE37059.1};
RC TISSUE=Thymus {ECO:0000313|EMBL:BAE37059.1};
RX PubMed=11042159; DOI=10.1101/gr.145100;
RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
RT "Normalization and subtraction of cap-trapper-selected cDNAs to prepare
RT full-length cDNA libraries for rapid discovery of new genes.";
RL Genome Res. 10:1617-1630(2000).
RN [3] {ECO:0000313|EMBL:BAE37059.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE37059.1};
RC TISSUE=Thymus {ECO:0000313|EMBL:BAE37059.1};
RX PubMed=11076861; DOI=10.1101/gr.152600;
RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N.,
RA Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R.,
RA Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S.,
RA Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y.,
RA Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y.,
RA Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
RT "RIKEN integrated sequence analysis (RISA) system--384-format sequencing
RT pipeline with 384 multicapillary sequencer.";
RL Genome Res. 10:1757-1771(2000).
RN [4] {ECO:0000313|EMBL:BAE37059.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE37059.1};
RC TISSUE=Thymus {ECO:0000313|EMBL:BAE37059.1};
RX PubMed=11217851; DOI=10.1038/35055500;
RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
RT "Functional annotation of a full-length mouse cDNA collection.";
RL Nature 409:685-690(2001).
RN [5] {ECO:0000313|EMBL:BAE37059.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE37059.1};
RC TISSUE=Thymus {ECO:0000313|EMBL:BAE37059.1};
RX PubMed=12466851; DOI=10.1038/nature01266;
RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
RT "Analysis of the mouse transcriptome based on functional annotation of
RT 60,770 full-length cDNAs.";
RL Nature 420:563-573(2002).
RN [6] {ECO:0000313|EMBL:BAE37059.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE37059.1};
RC TISSUE=Thymus {ECO:0000313|EMBL:BAE37059.1};
RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F.,
RA Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M.,
RA Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H., Nomura K.,
RA Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T.,
RA Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.;
RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:BAE37059.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE37059.1};
RC TISSUE=Thymus {ECO:0000313|EMBL:BAE37059.1};
RG The FANTOM Consortium;
RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
RT "The Transcriptional Landscape of the Mammalian Genome.";
RL Science 309:1559-1563(2005).
RN [8] {ECO:0000313|EMBL:BAE37059.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE37059.1};
RC TISSUE=Thymus {ECO:0000313|EMBL:BAE37059.1};
RX PubMed=16141073; DOI=10.1126/science.1112009;
RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
RT "Antisense Transcription in the Mammalian Transcriptome.";
RL Science 309:1564-1566(2005).
CC -!- SIMILARITY: Belongs to the GW182 family.
CC {ECO:0000256|ARBA:ARBA00007302}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK162788; BAE37059.1; -; mRNA.
DR AlphaFoldDB; Q3TRH0; -.
DR PeptideAtlas; Q3TRH0; -.
DR AGR; MGI:2443730; -.
DR MGI; MGI:2443730; Tnrc6b.
DR ChiTaRS; Tnrc6b; mouse.
DR GO; GO:0005829; C:cytosol; IEA:UniProt.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR CDD; cd12712; RRM_TNRC6B; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR019486; Argonaute_hook_dom.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR032226; TNRC6_PABC-bd.
DR InterPro; IPR034925; TNRC6B_RRM.
DR PANTHER; PTHR13020; TRINUCLEOTIDE REPEAT-CONTAINING GENE 6; 1.
DR PANTHER; PTHR13020:SF32; TRINUCLEOTIDE REPEAT-CONTAINING GENE 6B PROTEIN; 1.
DR Pfam; PF10427; Ago_hook; 1.
DR Pfam; PF16608; TNRC6-PABC_bdg; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
PE 2: Evidence at transcript level;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845}.
FT DOMAIN 4..120
FT /note="Argonaute hook"
FT /evidence="ECO:0000259|Pfam:PF10427"
FT DOMAIN 366..650
FT /note="TNRC6 PABC binding"
FT /evidence="ECO:0000259|Pfam:PF16608"
FT REGION 1..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 168..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 320..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 497..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 596..647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 734..768
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 814..838
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..340
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 615..647
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 745..764
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 838 AA; 89445 MW; C7CCDF5280DC9988 CRC64;
MDIDDGTSAW GDPNSYNYKN VNLWDKNSQG GPAPREPNLP TPMTGKSASD SKSMQDGWGE
SDGPVTGARH PSWEEEDDGG VWNTAGSQGS TSSHNSASWG QGGKKQMKCS LKGGNNDSWM
NPLAKQFSNM GLLSQTEDNP SSKMDLSVDK KFDVDKRTMN LGDFNDIMRK DRPGFRPPNS
KDLGTTDSGP YFEKGGSHGL FGNSTAQSRG LHTPVQPLSS SPGLRAQVPP QFISPQVSAS
MLKQFPNSGL NPGLFNVGPQ LSPQQIAMLS QLPQIPQFQL ACQLLLQQQQ QQQQLLQNQR
KISQAVRQQQ EQQLARMVSA LQQQQQQQQQ QQQRQPSMKH SPSHPVGPKP HLDNMVPNAL
NVGLPDLPTK GPIPGYGSGF SSGGMDYGMV GGKEAGTESR FKQWTSMMEG LPSVATQEAT
MHKNGAIVAP GKTRGGSPYN QFDIIPGDTL GGHTGPAGDS WLPAKSPPTN KIGSKSSNAS
WPPEFQPGVP WKGIQNIDPE SDPYVTPGSV LGGTTTSPIV DTDHQLLRDN TTGSNSSLNT
SLPSPGAWPY SASDNSFTNV HSTSAKFPDY KSTWSPDPIG HNPTHLSNKM WKNHISSRNT
TPLTRPPPGL TNPKPASPWS STAPRSVRGW GTQDSRIASA STWSDGGSVR PSYWLVLHNL
TPQIDGSTLR TICMQHGPLL TFHLNLTQGT ALIRYSTKQE AAKAQTALHM CVLGNTTILA
EFATEDEVSR FLAQAQPPTP AATPSAPATG WQSLETSQNQ ADPVGPALNL FGGSTGLGQW
SSSAGGSSGA DLAGTSLWGP PNYSSSLWGV PTVEDPHRMG SPAPLLPGDL LGGGSDSI
//
