ID Q3TTQ5_MOUSE Unreviewed; 328 AA.
AC Q3TTQ5;
DT 11-OCT-2005, integrated into UniProtKB/TrEMBL.
DT 11-OCT-2005, sequence version 1.
DT 27-MAR-2024, entry version 141.
DE RecName: Full=Mitochondrial fission regulator {ECO:0000256|RuleBase:RU369053};
GN Name=Mtfr1 {ECO:0000313|MGI:MGI:1914722};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAE36270.1};
RN [1] {ECO:0000313|EMBL:BAE36270.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE36270.1};
RC TISSUE=Testis {ECO:0000313|EMBL:BAE36270.1};
RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
RA Carninci P., Hayashizaki Y.;
RT "High-efficiency full-length cDNA cloning.";
RL Methods Enzymol. 303:19-44(1999).
RN [2] {ECO:0000313|EMBL:BAE36270.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE36270.1};
RC TISSUE=Testis {ECO:0000313|EMBL:BAE36270.1};
RX PubMed=11042159; DOI=10.1101/gr.145100;
RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
RT "Normalization and subtraction of cap-trapper-selected cDNAs to prepare
RT full-length cDNA libraries for rapid discovery of new genes.";
RL Genome Res. 10:1617-1630(2000).
RN [3] {ECO:0000313|EMBL:BAE36270.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE36270.1};
RC TISSUE=Testis {ECO:0000313|EMBL:BAE36270.1};
RX PubMed=11076861; DOI=10.1101/gr.152600;
RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N.,
RA Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R.,
RA Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S.,
RA Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y.,
RA Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y.,
RA Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
RT "RIKEN integrated sequence analysis (RISA) system--384-format sequencing
RT pipeline with 384 multicapillary sequencer.";
RL Genome Res. 10:1757-1771(2000).
RN [4] {ECO:0000313|EMBL:BAE36270.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE36270.1};
RC TISSUE=Testis {ECO:0000313|EMBL:BAE36270.1};
RX PubMed=11217851; DOI=10.1038/35055500;
RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
RT "Functional annotation of a full-length mouse cDNA collection.";
RL Nature 409:685-690(2001).
RN [5] {ECO:0000313|EMBL:BAE36270.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE36270.1};
RC TISSUE=Testis {ECO:0000313|EMBL:BAE36270.1};
RX PubMed=12466851; DOI=10.1038/nature01266;
RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
RT "Analysis of the mouse transcriptome based on functional annotation of
RT 60,770 full-length cDNAs.";
RL Nature 420:563-573(2002).
RN [6] {ECO:0000313|EMBL:BAE36270.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE36270.1};
RC TISSUE=Testis {ECO:0000313|EMBL:BAE36270.1};
RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F.,
RA Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M.,
RA Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H., Nomura K.,
RA Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T.,
RA Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.;
RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:BAE36270.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE36270.1};
RC TISSUE=Testis {ECO:0000313|EMBL:BAE36270.1};
RG The FANTOM Consortium;
RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
RT "The Transcriptional Landscape of the Mammalian Genome.";
RL Science 309:1559-1563(2005).
RN [8] {ECO:0000313|EMBL:BAE36270.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAE36270.1};
RC TISSUE=Testis {ECO:0000313|EMBL:BAE36270.1};
RX PubMed=16141073; DOI=10.1126/science.1112009;
RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
RT "Antisense Transcription in the Mammalian Transcriptome.";
RL Science 309:1564-1566(2005).
RN [9] {ECO:0007829|PubMed:17242355}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [10] {ECO:0000313|EMBL:ABC96324.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BALB/c {ECO:0000313|EMBL:ABC96324.1};
RC TISSUE=Testes {ECO:0000313|EMBL:ABC96324.1};
RX PubMed=17709566; DOI=10.1530/REP-07-0199;
RA Monticone M., Tonachini L., Tavella S., Degan P., Biticchi R., Palombi F.,
RA Puglisi R., Boitani C., Cancedda R., Castagnola P.;
RT "Impaired expression of genes coding for reactive oxygen species scavenging
RT enzymes in testes of Mtfr1/Chppr-deficient mice.";
RL Reproduction 134:483-492(2007).
RN [11] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May play a role in mitochondrial aerobic respiration. May
CC also regulate mitochondrial organization and fission.
CC {ECO:0000256|ARBA:ARBA00037378}.
CC -!- FUNCTION: Plays a role in mitochondrial aerobic respiration. Regulates
CC mitochondrial organization and fission.
CC {ECO:0000256|RuleBase:RU369053}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173,
CC ECO:0000256|RuleBase:RU369053}.
CC -!- SIMILARITY: Belongs to the MTFR1 family.
CC {ECO:0000256|ARBA:ARBA00005807, ECO:0000256|RuleBase:RU369053}.
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DR EMBL; DQ369744; ABC96324.1; -; mRNA.
DR EMBL; AK161251; BAE36270.1; -; mRNA.
DR RefSeq; NP_001240319.1; NM_001253390.1.
DR RefSeq; NP_001240320.1; NM_001253391.1.
DR RefSeq; NP_080458.1; NM_026182.5.
DR RefSeq; XP_006535589.1; XM_006535526.2.
DR RefSeq; XP_011248010.1; XM_011249708.2.
DR AlphaFoldDB; Q3TTQ5; -.
DR SMR; Q3TTQ5; -.
DR PeptideAtlas; Q3TTQ5; -.
DR Antibodypedia; 11925; 132 antibodies from 23 providers.
DR DNASU; 67472; -.
DR GeneID; 67472; -.
DR KEGG; mmu:67472; -.
DR AGR; MGI:1914722; -.
DR CTD; 9650; -.
DR MGI; MGI:1914722; Mtfr1.
DR VEuPathDB; HostDB:ENSMUSG00000027601; -.
DR HOGENOM; CLU_059135_0_0_1; -.
DR OMA; CPRIHFQ; -.
DR OrthoDB; 3401791at2759; -.
DR BioGRID-ORCS; 67472; 3 hits in 75 CRISPR screens.
DR ChiTaRS; Mtfr1; mouse.
DR ExpressionAtlas; Q3TTQ5; baseline and differential.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0009060; P:aerobic respiration; IEA:UniProtKB-UniRule.
DR GO; GO:0000266; P:mitochondrial fission; IEA:UniProtKB-UniRule.
DR InterPro; IPR007972; Mtfr1.
DR PANTHER; PTHR14215:SF1; MITOCHONDRIAL FISSION REGULATOR 1; 1.
DR PANTHER; PTHR14215; PROTEIN OF UNKNOWN FUNCTION DUF729; 1.
DR Pfam; PF05308; Mito_fiss_reg; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Mitochondrion {ECO:0000256|RuleBase:RU369053};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..328
FT /note="Mitochondrial fission regulator"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014309113"
FT REGION 95..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 166..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 283..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 136..163
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 95..112
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..198
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..297
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 328 AA; 35905 MW; 69C9352E2654B653 CRC64;
MLGWIKCLMR MWFQRVGVSM QSVLWSGKPY GSSRSIVRKI GTNLSLIQCP RVQFQLTSHA
TEWSPAHSGE DAVASFADVG LVATEEGECS IRLRAEVSSK PPHEDDPPCF EKPPSRHTSF
PSLSQDKPSP ERTLASEEAL QKISALENEL AALRAQIAKI VTLQEQQSPS AGCLDSSTSV
TVAPPPPPPP PPPPLPLVLH QSTSALDLIK ERREQRLSAG KTLATGHPKK PDMPNMLEIL
KDMNSVKLRS VKRSEKDVKP RPADTDHAAF IAEALKKKFA YRHNSQGETE RGIPKPESEA
TSEPALFGPH ILKSTGKMKA LIENVPDS
//
