ID Q3ZJA7_9EUKA Unreviewed; 367 AA.
AC Q3ZJA7;
DT 27-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 27-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=Tubulin alpha chain {ECO:0000256|RuleBase:RU000352};
DE Flags: Fragment;
OS Monocercomonoides exilis.
OC Eukaryota; Metamonada; Preaxostyla; Oxymonadida; Polymastigidae;
OC Monocercomonoides.
OX NCBI_TaxID=2049356 {ECO:0000313|EMBL:AAW22162.1};
RN [1] {ECO:0000313|EMBL:AAW22162.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PA203 {ECO:0000313|EMBL:AAW22162.1};
RX PubMed=16120804; DOI=10.1093/molbev/msi245;
RA Hampl V., Horner D.S., Dyal P., Kulda J., Flegr J., Foster P.G.,
RA Embley T.M.;
RT "Inference of the phylogenetic position of oxymonads based on nine genes:
RT support for metamonada and excavata.";
RL Mol. Biol. Evol. 22:2508-2518(2005).
CC -!- FUNCTION: Tubulin is the major constituent of microtubules, a cylinder
CC consisting of laterally associated linear protofilaments composed of
CC alpha- and beta-tubulin heterodimers. Microtubules grow by the addition
CC of GTP-tubulin dimers to the microtubule end, where a stabilizing cap
CC forms. Below the cap, tubulin dimers are in GDP-bound state, owing to
CC GTPase activity of alpha-tubulin. {ECO:0000256|RuleBase:RU000352}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC -!- SUBUNIT: Dimer of alpha and beta chains. A typical microtubule is a
CC hollow water-filled tube with an outer diameter of 25 nm and an inner
CC diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to
CC form protofilaments running lengthwise along the microtubule wall with
CC the beta-tubulin subunit facing the microtubule plus end conferring a
CC structural polarity. Microtubules usually have 13 protofilaments but
CC different protofilament numbers can be found in some organisms and
CC specialized cells. {ECO:0000256|RuleBase:RU000352}.
CC -!- SIMILARITY: Belongs to the tubulin family.
CC {ECO:0000256|ARBA:ARBA00009636, ECO:0000256|RuleBase:RU000352}.
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DR EMBL; AY831438; AAW22161.1; -; Genomic_DNA.
DR EMBL; AY831439; AAW22162.1; -; Genomic_DNA.
DR AlphaFoldDB; Q3ZJA7; -.
DR VEuPathDB; GiardiaDB:MONOS_4301; -.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
DR GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR CDD; cd02186; alpha_tubulin; 1.
DR Gene3D; 3.30.1330.20; Tubulin/FtsZ, C-terminal domain; 1.
DR Gene3D; 3.40.50.1440; Tubulin/FtsZ, GTPase domain; 1.
DR InterPro; IPR002452; Alpha_tubulin.
DR InterPro; IPR008280; Tub_FtsZ_C.
DR InterPro; IPR000217; Tubulin.
DR InterPro; IPR037103; Tubulin/FtsZ-like_C.
DR InterPro; IPR018316; Tubulin/FtsZ_2-layer-sand-dom.
DR InterPro; IPR036525; Tubulin/FtsZ_GTPase_sf.
DR InterPro; IPR017975; Tubulin_CS.
DR InterPro; IPR003008; Tubulin_FtsZ_GTPase.
DR PANTHER; PTHR11588; TUBULIN; 1.
DR PANTHER; PTHR11588:SF239; TUBULIN ALPHA CHAIN; 1.
DR Pfam; PF00091; Tubulin; 1.
DR Pfam; PF03953; Tubulin_C; 1.
DR PRINTS; PR01162; ALPHATUBULIN.
DR PRINTS; PR01161; TUBULIN.
DR SMART; SM00864; Tubulin; 1.
DR SMART; SM00865; Tubulin_C; 1.
DR SUPFAM; SSF55307; Tubulin C-terminal domain-like; 1.
DR SUPFAM; SSF52490; Tubulin nucleotide-binding domain-like; 1.
DR PROSITE; PS00227; TUBULIN; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU000352};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|RuleBase:RU000352};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU000352}.
FT DOMAIN 19..216
FT /note="Tubulin/FtsZ GTPase"
FT /evidence="ECO:0000259|SMART:SM00864"
FT DOMAIN 218..363
FT /note="Tubulin/FtsZ 2-layer sandwich"
FT /evidence="ECO:0000259|SMART:SM00865"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAW22162.1"
FT NON_TER 367
FT /evidence="ECO:0000313|EMBL:AAW22162.1"
SQ SEQUENCE 367 AA; 40385 MW; 5E2DBD820CD56F7C CRC64;
QPDGQMPSDK TIGGGDDAFN TFFSETGAGK HVPRAVFIDL EPTVADEVRS GTYRELFHPE
QIISGKEDAA NNYARGHYTI GKEIVDLCLD RIRKLADQCT GLQGFLVFSS VGGGTGAGLG
SLLLERLSVD YGRKSKLTFT IYPSPQISNA CVEPYNAVLS THSLLNHTEV CVMLDNEAIY
DICRRSLDIE RPTYTNLNRL IAQVISSLTA SLRFDGALNV DLCEFQTNLV PYPRIHFMLS
SYAPVVTPEK AYHENLSVAE ITNSAFEPAN MMAKCDPRHG KYMACCMMYR GDVVPKDVNA
AVATIKTKRT IQFVDWCPTG FKCGINYQPP TVVPGGDLAK VQRAVCMISN STAIAEVFSR
IDHKFDL
//
