ID Q45U80_CAERE Unreviewed; 257 AA.
AC Q45U80;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Low-density lipoprotein receptor-related protein 1 {ECO:0000313|EMBL:AAZ42353.1};
DE Flags: Fragment;
GN Name=lrp-1 {ECO:0000313|EMBL:AAZ42353.1};
OS Caenorhabditis remanei (Caenorhabditis vulgaris).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=31234 {ECO:0000313|EMBL:AAZ42353.1};
RN [1] {ECO:0000313|EMBL:AAZ42353.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=EM464 {ECO:0000313|EMBL:AAZ42353.1};
RA Tucker D.A., Nemeroff M.E.;
RT "Isolation of an mRNA for low-density lipoprotein receptor-related protein
RT 1 precursor (LRP-1) from Caenorhabditis remanei.";
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; DQ115356; AAZ42353.1; -; mRNA.
DR AlphaFoldDB; Q45U80; -.
DR HOGENOM; CLU_000085_0_0_1; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 1.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR24270:SF66; CUB AND LDLA DOMAIN, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR Pfam; PF00058; Ldl_recept_b; 1.
DR SMART; SM00181; EGF; 2.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00192; LDLa; 1.
DR SMART; SM00135; LY; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR SUPFAM; SSF101898; NHL repeat; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipoprotein {ECO:0000313|EMBL:AAZ42353.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:AAZ42353.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 37..98
FT /note="EGF-like calcium-binding"
FT /evidence="ECO:0000259|SMART:SM00179"
FT DOMAIN 58..98
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DOMAIN 99..143
FT /note="EGF-like calcium-binding"
FT /evidence="ECO:0000259|SMART:SM00179"
FT DOMAIN 102..143
FT /note="EGF-like"
FT /evidence="ECO:0000259|SMART:SM00181"
FT DISULFID 16..28
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 23..41
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 35..50
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAZ42353.1"
FT NON_TER 257
FT /evidence="ECO:0000313|EMBL:AAZ42353.1"
SQ SEQUENCE 257 AA; 27614 MW; B27C792E2B99CB45 CRC64;
DEHLSMCSSF SEYGDCTSDQ FKCANGRCVN GTLACDRKDD CGDASDEIGC SKHGGKTSCE
SFGNNGGCKH ICTDITDSFY CHCRDGFRPD PQSPKDCIDI DECAGNNTCT QLCLNTKGSY
LCRCHEDYEN NVVVGSMTGK DCRAKGDAAN VMIGADSSLV QLSLHGAGTN RHAAAKANDE
DNDIIGIAFD PRKEMMYWID GSERTIYRSA IANGNQSHEG QKLDIDFAGM GVVPTAIAVD
YTTGNLFVAA VSEDIEI
//
