ID Q46YI5_CUPPJ Unreviewed; 482 AA.
AC Q46YI5;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE SubName: Full=Xanthine/uracil permease {ECO:0000313|EMBL:AAZ61798.1};
GN OrderedLocusNames=Reut_A2436 {ECO:0000313|EMBL:AAZ61798.1};
OS Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Cupriavidus necator
OS (strain JMP 134)).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Cupriavidus.
OX NCBI_TaxID=264198 {ECO:0000313|EMBL:AAZ61798.1};
RN [1] {ECO:0000313|EMBL:AAZ61798.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JMP134 {ECO:0000313|EMBL:AAZ61798.1};
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M., Schmutz J.,
RA Larimer F., Land M., Lykidis A., Richardson P.;
RT "Complete sequence of Chromosome1 of Ralstonia eutropha JMP134.";
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
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DR EMBL; CP000090; AAZ61798.1; -; Genomic_DNA.
DR AlphaFoldDB; Q46YI5; -.
DR STRING; 264198.Reut_A2436; -.
DR KEGG; reu:Reut_A2436; -.
DR eggNOG; COG2233; Bacteria.
DR HOGENOM; CLU_017959_8_2_4; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0015205; F:nucleobase transmembrane transporter activity; IEA:UniProt.
DR InterPro; IPR006043; NCS2.
DR InterPro; IPR017588; UacT-like.
DR InterPro; IPR006042; Xan_ur_permease.
DR NCBIfam; TIGR00801; ncs2; 1.
DR NCBIfam; NF037981; NCS2_1; 1.
DR NCBIfam; TIGR03173; pbuX; 1.
DR PANTHER; PTHR42810; PURINE PERMEASE C1399.01C-RELATED; 1.
DR PANTHER; PTHR42810:SF4; URIC ACID TRANSPORTER UACT; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
DR PROSITE; PS01116; XANTH_URACIL_PERMASE; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 36..57
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 69..92
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 99..117
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 123..142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 154..176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 196..217
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 351..367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 379..400
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 412..432
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 438..461
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 482 AA; 50395 MW; 9D8D452B84DCA500 CRC64;
MPVFPSNQRR GDAPMTSAST TVPTDLTNER LPSGRLLALG LQHVLVMYAG TVAVPLIVGG
ALKLPKDQLA FLINADLFAA GLATLIQAFG FWKFGIRMPV MMGVTFASVA PMIAIGTDPN
VGLLGIYGAV IASGVFGILV APMMGRMLGL FPPVVTGTVI TLIGVSLMRV GINWAAGGQP
TTRAVIDGVV KEVPNLAYGD LANLGIAGLT LAVILLLTKY GRGLVANCAV LLGIIAGTFV
AMAMGKVSFE GLNEASFVAV ITPLHFGIPT FELSAILSMC IVMLITLVES TGMFLALSDI
TGKKLSNEDL TRGLRADGLG TVIGGLFNTF PYTSFSQNVG LVTVTGVRSR YVAAAGGIIL
IAFGLFPKMA HVVASVPQFV LGGAGIVMFG MVAATGIRIL GSCDFNRNRH NLFIVAISIG
FGMIPTLAPT FFQYLPKWTV PFTHSGIVLG TIVAVALNLF YNGIQSREEA MRNAAANTHG
TE
//
