ID Q47T93_THEFY Unreviewed; 1406 AA.
AC Q47T93;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 140.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN OrderedLocusNames=Tfu_0286 {ECO:0000313|EMBL:AAZ54324.1};
OS Thermobifida fusca (strain YX).
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Nocardiopsaceae; Thermobifida.
OX NCBI_TaxID=269800 {ECO:0000313|EMBL:AAZ54324.1};
RN [1] {ECO:0000313|EMBL:AAZ54324.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=YX {ECO:0000313|EMBL:AAZ54324.1};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Pitluck S., Di Bartolo G., Chain P., Schmutz J.,
RA Larimer F., Land M., Lykidis A., Richardson P.;
RT "Complete sequence of Thermobifida fusca YX.";
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; CP000088; AAZ54324.1; -; Genomic_DNA.
DR STRING; 269800.Tfu_0286; -.
DR KEGG; tfu:Tfu_0286; -.
DR eggNOG; COG0745; Bacteria.
DR eggNOG; COG1511; Bacteria.
DR eggNOG; COG2203; Bacteria.
DR eggNOG; COG2205; Bacteria.
DR HOGENOM; CLU_000445_3_0_11; -.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd06225; HAMP; 6.
DR CDD; cd16922; HATPase_EvgS-ArcB-TorS-like; 1.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 1.20.120.1530; -; 4.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 1.10.287.950; Methyl-accepting chemotaxis protein; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR45339; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J; 1.
DR PANTHER; PTHR45339:SF1; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J; 1.
DR Pfam; PF13185; GAF_2; 1.
DR Pfam; PF00672; HAMP; 4.
DR Pfam; PF18947; HAMP_2; 3.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00304; HAMP; 8.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF58104; Methyl-accepting chemotaxis protein (MCP) signaling domain; 3.
DR PROSITE; PS50885; HAMP; 7.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AAZ54324.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AAZ54324.1}.
FT DOMAIN 104..161
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 201..253
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 293..345
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 385..437
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 477..529
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 569..621
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 661..713
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 964..1197
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 1276..1393
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT REGION 1224..1247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 885..954
FT /evidence="ECO:0000256|SAM:Coils"
FT MOD_RES 1326
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 1406 AA; 153442 MW; F869629E2A9CAD45 CRC64;
MPRLMPRMKN RTLTESELDA LLDALYRMRD GDFTVRLSPR GATRFSEVAR VLNEVFDQCE
QLSNEVQWVS ETVSTDGRLS ERVSISPARG SWGQSVRALN QMLDEVSEPV TAVARILDSV
ANGDLSQRVD LASRHGELHG DLLRLATSVN RMADQMSEFA GEVTRVAREV GTEGKLGGRA
NVKGVSGIWK DLTDNVNSMA DNLTNQVRDI SQVTTAVARG DLTKKVTVDV QGEMLQLKDT
VNTMVDQLST FADEVTRVAR EVGTEGKLGG RANVKGVSGI WKDLTDNVNS MADNLTNQVR
DISQVTTAVA RGDLTKKVTV DVQGEMLQLK DTVNTMVDQL STFADEVTRV AREVGTEGKL
GGRANVKGVS GIWKDLTDNV NSMADSLTHQ VRNISQVTSA VAAGDLTKKI TVDAQGEILE
LKDTVNTMVD QLSAFADEVT RVAREVGTEG KLGGQAHVSG VSGVWKDLTD NVNSMANNLT
HQVRQISVVT TAVARGDLTK KVTVNAKGEI LELKDTINTM VDQLSTFADE VTRVTREVGT
EGKLGGRANV KGVSGIWKDL TDNVNSMSHN LTTQVRNISQ VTTAVARGDL TKRITVDAQG
EMLELKDTIN TMVDQLSTFA LEVTRVGHEV GIEGKLGVQA KVAGVSGVWK DLTDSVNELA
KNLTTQVRAI ASVASAVARG DLTQSIQVSA RGELATLKDN VNLMVSNLRE TTAAQRDEDW
LKSNLARLSG LLQGRRDLNE LARLIMTEVT PLVDAQHGAC YLPEDENDTE TFRLYAGYGY
QPSEERRRIT AGQGLAGEAI AQRKELIVHN VPGDYVRIES GLGEAPPLSL AIFPIVSEDR
VLGVIELGSY GTFREIHLNF LRQLVSLLSA TITTILANSK TEYLLAQSQQ LTTALQERSN
ELQRQQEELR RKNAELHSKA GQLASQNRAI ELQNRQIERA RRSLEDRAHQ LQVSSKYKSE
FLANMSHELR TPLNSLLILA RLLADNSEKN LTPKQVEFAQ TIYKAGSDLL QLINEILDLS
KVEAGRMELN PSHVSISQLV DYVEASFRPL ASEKGLAFAV EVSPDVPDQL WTDEQRLQQV
LRNLLSNAVK FTSSGEVRLV IEPAWAVEDI DVDTFTDPDE VIAFSVIDTG IGIPEDKLQL
IFEAFHQGDG GTSRRFGGTG LGLSISRNMA ELLGGEIRVS STVGEGSTFT LLLPVRLPEG
TSERMYRSLS DADVVTSFDR PTDTVVLPTE TPGPKAADTD PLASSEDEPY VPVLTAESVP
QAAGGPQQDD VLAGKRVLIV DDDIRNVFAL ASALEAHGLE VLYADNGREG IAKLEANEDI
DLVLMDIMMP ELDGDATTRM IREMPQFADL PIISLTAKAM RGDRENSLAA GASDYVSKPV
DLDHLLNVMR RWLDRGKSDN STSREQ
//
