ID Q49BB6_STRHY Unreviewed; 497 AA.
AC Q49BB6;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE SubName: Full=Putative integral membrane protein {ECO:0000313|EMBL:AAY46811.1};
GN ORFNames=SHXM_00998 {ECO:0000313|EMBL:AQW47535.1};
OS Streptomyces hygroscopicus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces violaceusniger group.
OX NCBI_TaxID=1912 {ECO:0000313|EMBL:AAY46811.1};
RN [1] {ECO:0000313|EMBL:AAY46811.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NRRL 3602 {ECO:0000313|EMBL:AAY46811.1};
RX PubMed=16085885; DOI=10.1128/AEM.71.8.4862-4871.2005;
RA Rascher A., Hu Z., Buchanan G.O., Reid R., Hutchinson C.R.;
RT "Insights into the biosynthesis of the benzoquinone ansamycins geldanamycin
RT and herbimycin, obtained by gene sequencing and disruption.";
RL Appl. Environ. Microbiol. 71:4862-4871(2005).
RN [2] {ECO:0000313|EMBL:AQW47535.1, ECO:0000313|Proteomes:UP000191078}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=XM201 {ECO:0000313|EMBL:AQW47535.1,
RC ECO:0000313|Proteomes:UP000191078};
RA Wang X., Bai L.;
RT "PKS gene overexpression with strong endogenous promoters resulted in
RT improved geldanamycin production.";
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AY952143; AAY46811.1; -; Genomic_DNA.
DR EMBL; CP018627; AQW47535.1; -; Genomic_DNA.
DR AlphaFoldDB; Q49BB6; -.
DR Proteomes; UP000191078; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR InterPro; IPR025711; PepSY.
DR InterPro; IPR005625; PepSY-ass_TM.
DR PANTHER; PTHR34219; IRON-REGULATED INNER MEMBRANE PROTEIN-RELATED; 1.
DR PANTHER; PTHR34219:SF1; PEPSY DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF03413; PepSY; 1.
DR Pfam; PF03929; PepSY_TM; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 52..73
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 188..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 241..262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 407..427
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 448..466
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 98..156
FT /note="PepSY"
FT /evidence="ECO:0000259|Pfam:PF03413"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 497 AA; 52640 MW; 8706C2106DD7DE1A CRC64;
MSAEPLAPAT GDSPDDVADR EPRSLAEAES GGSGSGGSVW AGLRPLVLRL HFYAGVLVAP
FLLVAAVTGL LYAGSFQAEK LVYAHELRVP VGDRELPISA QVAAARKGHP EGEISAVRPS
PEDGATTRVL LSGVKGVDPD HTLAVFVDPY TGKVRGALEQ YGSTGALPLR TWIDEFHRDL
HLGQTGRLYS ELAASWLWVI ALGGVVLWLS RRRKKRTLRA VALPDRAATG RKRTMSFHGA
VGLWVALGLL FLSATGLTWS TYAGANVEDL RTALGQTTPT VSATVGGGEH AGHHMGSGSM
PGMDMGGTGE AAGHTADAGL DTVLAAARAK DLDNPVEIVP PAEPGSAYVV SQIQRSWPEK
QDSVAVDPAT GEVTDVQRFA DYPVLAKLTR WGIDLHTGNL FGLVNQIALA ALALALILLI
VWGYRMWWQR GRASAFGRPI PRGAWRRVPL YVLVPLAAAT AVIGYYLPLL GIPLATFLAV
DIVAGEIARR RRAAPAA
//
