ID Q49ZA5_STAS1 Unreviewed; 144 AA.
AC Q49ZA5;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE RecName: Full=Mannitol-specific phosphotransferase enzyme IIA component {ECO:0000256|ARBA:ARBA00014783};
DE AltName: Full=EIIA {ECO:0000256|ARBA:ARBA00030956};
DE AltName: Full=EIII {ECO:0000256|ARBA:ARBA00030962};
DE AltName: Full=PTS system mannitol-specific EIIA component {ECO:0000256|ARBA:ARBA00029908};
GN OrderedLocusNames=SSP0726 {ECO:0000313|EMBL:BAE17871.1};
OS Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM
OS 20229 / NCIMB 8711 / NCTC 7292 / S-41).
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=342451 {ECO:0000313|EMBL:BAE17871.1, ECO:0000313|Proteomes:UP000006371};
RN [1] {ECO:0000313|EMBL:BAE17871.1, ECO:0000313|Proteomes:UP000006371}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41
RC {ECO:0000313|Proteomes:UP000006371};
RX PubMed=16135568; DOI=10.1073/pnas.0502950102;
RA Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M.,
RA Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.;
RT "Whole genome sequence of Staphylococcus saprophyticus reveals the
RT pathogenesis of uncomplicated urinary tract infection.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005).
CC -!- FUNCTION: The phosphoenolpyruvate-dependent sugar phosphotransferase
CC system (sugar PTS), a major carbohydrate active transport system,
CC catalyzes the phosphorylation of incoming sugar substrates
CC concomitantly with their translocation across the cell membrane. The
CC enzyme II CmtAB PTS system is involved in D-mannitol transport.
CC {ECO:0000256|ARBA:ARBA00002434}.
CC -!- SUBUNIT: Homodimer or homotrimer. Seems to be a monomer when not
CC phosphorylated. {ECO:0000256|ARBA:ARBA00011798}.
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DR EMBL; AP008934; BAE17871.1; -; Genomic_DNA.
DR RefSeq; WP_002482673.1; NZ_MTGA01000032.1.
DR AlphaFoldDB; Q49ZA5; -.
DR GeneID; 66866882; -.
DR KEGG; ssp:SSP0726; -.
DR PATRIC; fig|342451.11.peg.728; -.
DR eggNOG; COG4668; Bacteria.
DR HOGENOM; CLU_072531_3_0_9; -.
DR OrthoDB; 1640042at2; -.
DR Proteomes; UP000006371; Chromosome.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW.
DR CDD; cd00211; PTS_IIA_fru; 1.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR InterPro; IPR002178; PTS_EIIA_type-2_dom.
DR PANTHER; PTHR30181; MANNITOL PERMEASE IIC COMPONENT; 1.
DR PANTHER; PTHR30181:SF2; PTS SYSTEM MANNITOL-SPECIFIC EIICBA COMPONENT; 1.
DR Pfam; PF00359; PTS_EIIA_2; 1.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
DR PROSITE; PS51094; PTS_EIIA_TYPE_2; 1.
DR PROSITE; PS00372; PTS_EIIA_TYPE_2_HIS; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Phosphotransferase system {ECO:0000256|ARBA:ARBA00022683};
KW Reference proteome {ECO:0000313|Proteomes:UP000006371};
KW Sugar transport {ECO:0000256|ARBA:ARBA00022597};
KW Transferase {ECO:0000313|EMBL:BAE17871.1};
KW Transport {ECO:0000256|ARBA:ARBA00022597}.
FT DOMAIN 3..142
FT /note="PTS EIIA type-2"
FT /evidence="ECO:0000259|PROSITE:PS51094"
SQ SEQUENCE 144 AA; 15634 MW; C6F5FFC98612670A CRC64;
MSELFSNENI FINQTVKDQN EAIEKAGHAL VSSGAVTEDY IQAMKDREQV VSTFMGNGLA
IPHGTDEAKT SVLKSGLTLI QIPEGVDWEG EEVKVVVGIA GKDGEHLDLL SKIAITFSEE
ENVDRIINAS SAEEIKQVFE EAEA
//
