ID Q4A3A7_EHV8U Unreviewed; 358 AA.
AC Q4A3A7;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 08-NOV-2023, entry version 70.
DE SubName: Full=Putative endonuclease {ECO:0000313|EMBL:CAI65441.1};
GN ORFNames=EhV018 {ECO:0000313|EMBL:CAI65441.1};
OS Emiliania huxleyi virus 86 (isolate United Kingdom/English Channel/1999)
OS (EhV-86).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC Algavirales; Phycodnaviridae; Coccolithovirus; Emiliania huxleyi virus 86.
OX NCBI_TaxID=654925 {ECO:0000313|EMBL:CAI65441.1, ECO:0000313|Proteomes:UP000000863};
OH NCBI_TaxID=2903; Emiliania huxleyi (Coccolithophore) (Pontosphaera huxleyi).
RN [1] {ECO:0000313|EMBL:CAI65441.1, ECO:0000313|Proteomes:UP000000863}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate United Kingdom/English Channel/1999
RC {ECO:0000313|Proteomes:UP000000863};
RX PubMed=16099989; DOI=10.1126/science.1113109;
RA Wilson W.H., Schroeder D.C., Allen M.J., Holden M.T.G., Parkhill J.,
RA Barrell B.G., Churcher C., Hamlin N., Mungall K., Norbertczak H.,
RA Quail M.A., Price C., Rabbinowitsch E., Walker D., Craigon M., Roy D.,
RA Ghazal P.;
RT "Complete genome sequence and lytic phase transcription profile of a
RT Coccolithovirus.";
RL Science 309:1090-1092(2005).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR EMBL; AJ890364; CAI65441.1; -; Genomic_DNA.
DR RefSeq; YP_293772.1; NC_007346.1.
DR GeneID; 3655015; -.
DR KEGG; vg:3655015; -.
DR Proteomes; UP000000863; Segment.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd09867; PIN_FEN1; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR HAMAP; MF_00614; Fen; 1.
DR InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR InterPro; IPR023426; Flap_endonuc.
DR InterPro; IPR008918; HhH2.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR006086; XPG-I_dom.
DR InterPro; IPR006084; XPG/Rad2.
DR InterPro; IPR019974; XPG_CS.
DR InterPro; IPR006085; XPG_DNA_repair_N.
DR PANTHER; PTHR11081:SF9; FLAP ENDONUCLEASE 1; 1.
DR PANTHER; PTHR11081; FLAP ENDONUCLEASE FAMILY MEMBER; 1.
DR Pfam; PF00867; XPG_I; 1.
DR Pfam; PF00752; XPG_N; 1.
DR PRINTS; PR00853; XPGRADSUPER.
DR SMART; SM00279; HhH2; 1.
DR SMART; SM00484; XPGI; 1.
DR SMART; SM00485; XPGN; 1.
DR SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
DR PROSITE; PS00841; XPG_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759, ECO:0000313|EMBL:CAI65441.1};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000000863}.
FT DOMAIN 1..108
FT /note="XPG N-terminal"
FT /evidence="ECO:0000259|SMART:SM00485"
FT DOMAIN 144..216
FT /note="XPG-I"
FT /evidence="ECO:0000259|SMART:SM00484"
SQ SEQUENCE 358 AA; 40106 MW; 27F5EBC565FA49A0 CRC64;
MGINGLSRLI NNKAHNGTSN KDLDLLSGKV IMIDASMQIY QCLIAIRQGP SGQLAACEGE
VTSHLTGIFY RTIRLIEAGI KPVYVFDGKP PVLKKKELDK RNERQAQALS ELKLTDDATE
VEKQEKRSVR ATREHSEEVK KMLTLMGIPV VQAPCEAEAT CAAYVKTGKA YATATEDMDS
LTFGSTYVIR HINSTDQKKQ PTVEYSLPNI LNDMGITMDQ FIEICILSGC DYTKTIKGIG
PTRAYQLIQE HSTIENVLDV LKKKHGEEQF STMVPDDYPI EAVRDLFNNP DVDITQELTW
NTINRDALIA FLVEEKKFSA DRVNKGCDRI LAAKAKGTQH RINHFFKVKQ TPVGQKRK
//
