ID Q4CL73_TRYCC Unreviewed; 578 AA.
AC Q4CL73;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Dynein heavy chain, putative {ECO:0000313|EMBL:EAN81025.1};
DE Flags: Fragment;
GN ORFNames=Tc00.1047053508829.9 {ECO:0000313|EMBL:EAN81025.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN81025.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN81025.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN81025.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN81025.1}.
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DR EMBL; AAHK01004965; EAN81025.1; -; Genomic_DNA.
DR RefSeq; XP_802471.1; XM_797378.1.
DR AlphaFoldDB; Q4CL73; -.
DR SMR; Q4CL73; -.
DR STRING; 353153.Q4CL73; -.
DR PaxDb; 353153-Q4CL73; -.
DR EnsemblProtists; EAN81025; EAN81025; Tc00.1047053508829.9.
DR GeneID; 3531757; -.
DR KEGG; tcr:508829.9; -.
DR eggNOG; KOG3595; Eukaryota.
DR InParanoid; Q4CL73; -.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0030286; C:dynein complex; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF34; DYNEIN HEAVY CHAIN, CYTOPLASMIC; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT DOMAIN 115..201
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 278..537
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EAN81025.1"
FT NON_TER 578
FT /evidence="ECO:0000313|EMBL:EAN81025.1"
SQ SEQUENCE 578 AA; 65989 MW; E1014B248E42A361 CRC64;
KVVLFIDDLN MPALETFGAS PPIELLRQMM GNGGFYDRKV AGFWKHVQDV TVVAACGPPE
GGRNPVTARL TRLFHLLHIP TLSDESMKRI FHSILQGFFQ AKNFSGEVRD MAKSLVNASV
EIFNKTRDTM RPKPTTPHYT FNLRDLAKVF QGITQVTPRV CKLKRSVTRL WIHELLRCFY
DRLATQEDRT YFTEDLMMDA LTRFVSGQHS HADYFEGDPL VWADFLRIGA VDRVYEELTE
FKKLPGILSD YQDDYNAYMS GGTGREDDDG SGGAKSVLNL VFFKDHCEHL VRIIRILRQP
RGNALLVGVG GSGKRSLTRL AASIAERQTL EIAVGKGYSM NEFHEFLLDL YTTAGVQCKP
CVFLISDNQI VHEGMLEDVN NILNSGEVPS LFTPDEREKR VSACLEAAQE RGISDRDDVY
NFFISRVRDN MHIVLCMSPV GDTFRTRCRQ FPSLTNCCVI DWFDEWPKEA LLGVAQRLFE
DADGGESNQL LPILAPLCVD IHTTVIRVAH EYWEELRRRY YITPTSYLEF IELYKALYSE
QRAVLEEQLS RVVNGKQKMK ETDETIAKMK EEMRQNAP
//
