ID Q4D1X8_TRYCC Unreviewed; 406 AA.
AC Q4D1X8;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 24-JAN-2024, entry version 63.
DE RecName: Full=RNA uridylyltransferase {ECO:0000256|ARBA:ARBA00012472};
DE EC=2.7.7.52 {ECO:0000256|ARBA:ARBA00012472};
GN ORFNames=Tc00.1047053503805.10 {ECO:0000313|EMBL:EAN86527.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN86527.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN86527.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN86527.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=RNA(n) + UTP = diphosphate + RNA(n)-3'-uridine ribonucleotide;
CC Xref=Rhea:RHEA:14785, Rhea:RHEA-COMP:14527, Rhea:RHEA-COMP:17348,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:46398, ChEBI:CHEBI:140395,
CC ChEBI:CHEBI:173116; EC=2.7.7.52;
CC Evidence={ECO:0000256|ARBA:ARBA00024498};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN86527.1}.
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DR EMBL; AAHK01001201; EAN86527.1; -; Genomic_DNA.
DR RefSeq; XP_808378.1; XM_803285.1.
DR AlphaFoldDB; Q4D1X8; -.
DR SMR; Q4D1X8; -.
DR PaxDb; 353153-Q4D1X8; -.
DR EnsemblProtists; EAN86527; EAN86527; Tc00.1047053503805.10.
DR GeneID; 3538781; -.
DR KEGG; tcr:503805.10; -.
DR eggNOG; KOG2277; Eukaryota.
DR InParanoid; Q4D1X8; -.
DR OrthoDB; 1080369at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0050265; F:RNA uridylyltransferase activity; IEA:UniProt.
DR GO; GO:0071076; P:RNA 3' uridylation; IEA:UniProt.
DR CDD; cd05402; NT_PAP_TUTase; 1.
DR Gene3D; 1.10.1410.10; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR PANTHER; PTHR12271:SF97; MITOCHONDRIAL EDITOSOME-LIKE COMPLEX ASSOCIATED TUTASE; 1.
DR PANTHER; PTHR12271; POLY A POLYMERASE CID PAP -RELATED; 1.
DR Pfam; PF01909; NTP_transf_2; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81631; PAP/OAS1 substrate-binding domain; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT DOMAIN 41..132
FT /note="Polymerase nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF01909"
SQ SEQUENCE 406 AA; 47006 MW; AFCA79B396072A51 CRC64;
MNAARRKFIK DMMAHYRASQ PPTDHETILK DLQERVLDIG LRSVNKAHVE LFGSHVSGFC
KPTSDVDLSL TYRNFSPWLQ GMERVDEQNN KRMMRFSKEA AEMGMEDVRY IRARIPVVQF
IDSLSGLHCD LSIGNVGGVE NSKILAAIRE VFPDFYRAYI HLVKEWGKAR EVIAPERSTF
NSFTVTTMAL MVLQELGLLP VFSKPTGDFG ELTLPDVQLQ LESFKLPAIY DSLQGDDEKL
GEAVFFCLQR FAEYYSKYDF RSGTVSLIHP RRHRSVYEKV VKQYLERLGV KKRIEWEKHL
AEHKEDGAFD ENDFSAAMQN EATQRPCTSP FVVEDFVNYV NCGRRVQATR VQHVQQEFNR
LHEMLVDKEK ELDFEEVFRE SDVVPRFHGF EGVGARDPRV KTFRAR
//