ID Q4D2S9_TRYCC Unreviewed; 544 AA.
AC Q4D2S9;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EAN86827.1};
GN ORFNames=Tc00.1047053506389.10 {ECO:0000313|EMBL:EAN86827.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN86827.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN86827.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN86827.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN86827.1}.
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DR EMBL; AAHK01001140; EAN86827.1; -; Genomic_DNA.
DR RefSeq; XP_808678.1; XM_803585.1.
DR AlphaFoldDB; Q4D2S9; -.
DR SMR; Q4D2S9; -.
DR PaxDb; 353153-Q4D2S9; -.
DR EnsemblProtists; EAN86827; EAN86827; Tc00.1047053506389.10.
DR GeneID; 3539146; -.
DR KEGG; tcr:506389.10; -.
DR eggNOG; ENOG502SNPZ; Eukaryota.
DR InParanoid; Q4D2S9; -.
DR OMA; GHNTNER; -.
DR OrthoDB; 3887240at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR026856; Sialidase_fam.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR InterPro; IPR021287; Trans-sialidase_CS.
DR PANTHER; PTHR10628; SIALIDASE; 1.
DR PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR Pfam; PF13859; BNR_3; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF11052; Tr-sialidase_C; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 5..213
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EAN86827.1"
SQ SEQUENCE 544 AA; 57757 MW; 137AE66889243D76 CRC64;
KIYGKDTSVT PWTEFEKQHK SLTGLIGGGG SGVQTKDGTL VLPVEGTKDG KAVSLIICYS
VTEGGKLSKG MSADGCSDPS VVEWKGKLMM MTACDDGRRR VYEIGDKGES WTEALGTLSR
VWGNNQKRHE KGVGSGFSTA TIGNRDVMLV TLPVYSNRKG KEKRELHLWL TDNTHIVDIG
PVSGDDDAAA SSLLYKSAGG GHNTNERLIA LYEKKKGDGE SSLGMVSVRL TAQLKRVREV
LATWKEVDGR VSKLCPSTAA KNPSTGNGCS AVKITDGLVG FLSKNFSGNT WKDEYLGVNA
TVRKGTNGVA TGYADGVTFH GAWAEWPVGR QGENQLYHFA NHNFTLVATL SVHGEPKGDT
PIPLMGATMN DNKKTVLLGL SYDKEGKWQL LCGGKTTKEL RSNWEPETTH QVAIVLRNGT
QCSAYVDGQR VGDAPCELNN TDSKGISHFY IGGDGGSAGS KEDVPVTATN VLLYNRPLDD
NAIRVLNANK ISIPKLTGLK TVAAEATGVG AARHFGANGD GSAVCGGGLL PLLLLLGLWG
IAAS
//
