ID Q4D326_TRYCC Unreviewed; 953 AA.
AC Q4D326;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE RecName: Full=Probable helicase A859L {ECO:0000256|ARBA:ARBA00019253};
GN ORFNames=Tc00.1047053506495.20 {ECO:0000313|EMBL:EAN86926.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN86926.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN86926.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN86926.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- SIMILARITY: Belongs to the asfivirus helicase A859L family.
CC {ECO:0000256|ARBA:ARBA00007303}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN86926.1}.
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DR EMBL; AAHK01001120; EAN86926.1; -; Genomic_DNA.
DR RefSeq; XP_808777.1; XM_803684.1.
DR AlphaFoldDB; Q4D326; -.
DR SMR; Q4D326; -.
DR PaxDb; 353153-Q4D326; -.
DR EnsemblProtists; EAN86926; EAN86926; Tc00.1047053506495.20.
DR GeneID; 3539273; -.
DR KEGG; tcr:506495.20; -.
DR eggNOG; ENOG502QT82; Eukaryota.
DR InParanoid; Q4D326; -.
DR OMA; TCFTPEW; -.
DR OrthoDB; 160114at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR018306; Phage_T5_Orf172_DNA-bd.
DR PANTHER; PTHR11274:SF13; HELICASE A859L-RELATED; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF04851; ResIII; 1.
DR Pfam; PF10544; T5orf172; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00974; T5orf172; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000313|EMBL:EAN86926.1};
KW Helicase {ECO:0000313|EMBL:EAN86926.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000313|EMBL:EAN86926.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT DOMAIN 255..434
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 467..616
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 154..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 887..914
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 953 AA; 110499 MW; 960622F0F38349E7 CRC64;
MRKIHIYDDL FFFFPLHLLN LGRTTKTTKQ QRHQMANRTR LFNCAYGFYI AMHPWLKGSG
YVKVGYTANL SRRLEMASFT TCFTPEWSYF AVFELESIKE AFLLEQAVLF LFKDRRVSNR
ELIQGSAKEV LEGARRVCLA LNLNALVNMQ PNYSSTESPV RGRSGRELFP DNVSSTHNAL
RPNTLGRYME ALEKLYDSVR KPALCDKITV DRGEKFAENE EEEEYDLDVL ETYKEESFSL
TKLRPYQQEA VTRCREELES HGATICQMAC RCGKTPVAFK IIEYYLKNKR DTRVLYLVPG
LTLLRQTVRK LYSYGLREIK YLLIGSYPTS VSLGDGNSLM MTTDEGVIEN VFKGSSSQMV
VISTYQSSHI VSKLSVFDLT VFDECHRVCG SASITNFNSV LFQPRSGNRL FLTATPAYDT
PIKMDNTHLF GGIAYRYYLR EGIDAGYVNA FSLRIVLGEE MDDMNPYFYE AMRIVDKMIV
YCRSIEHAIQ LTESLKCPFP DDTVPFNVML AHSRMGCRVV TDVLRDFSAS KRCILFNVRL
FQEGVEIPDL NAVFFAAPRY SSRDIVQSIC RPLNKMENKP KSYVFLPATI DKNLPETHPV
NLQKFSTLIP FTDALMDEDP ILFEYLIDPQ KVSYDIDVVG LRSLKLSSER LRKFVLPAIR
RGVRYTNQNT DRLHRAARIP WKSAFGELRR IVLECNRYPK TNDAWVIGKK SVSMALFYRY
ARKGYRQYMN HEPSYLKVYQ IRDLESLPLW QSYGMQGPYP WEECLRTLRN YLSMHAHVPP
LDVHKGGYIG LDATPFERLS GALMHINQCD AHDKLRLDLS KQKDLDDLCG AYGLKWRKRR
DASGKVIPGE TTFINESYER FKKLYGSCHR NQFQKYIDQH FPGYPEKHER MEDPRNLKKG
RVPPRHVSRD ERNKMHSAGR VMCRVCRRHI AVKAWERHLK SHPHLAKLQQ VTL
//
