ID Q4D4B5_TRYCC Unreviewed; 792 AA.
AC Q4D4B5;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EAN87367.1};
GN ORFNames=Tc00.1047053508451.60 {ECO:0000313|EMBL:EAN87367.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN87367.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN87367.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN87367.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN87367.1}.
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DR EMBL; AAHK01001045; EAN87367.1; -; Genomic_DNA.
DR RefSeq; XP_809218.1; XM_804125.1.
DR AlphaFoldDB; Q4D4B5; -.
DR SMR; Q4D4B5; -.
DR PaxDb; 353153-Q4D4B5; -.
DR EnsemblProtists; EAN87367; EAN87367; Tc00.1047053508451.60.
DR GeneID; 3539803; -.
DR KEGG; tcr:508451.60; -.
DR VEuPathDB; TriTrypDB:TcCLB.508451.60; -.
DR eggNOG; ENOG502S3YU; Eukaryota.
DR InParanoid; Q4D4B5; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR026856; Sialidase_fam.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR InterPro; IPR021287; Trans-sialidase_CS.
DR PANTHER; PTHR10628; SIALIDASE; 1.
DR PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR Pfam; PF13859; BNR_3; 1.
DR Pfam; PF11052; Tr-sialidase_C; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 112..457
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT REGION 16..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 792 AA; 85874 MW; C16E21309EA79990 CRC64;
MLSRVAAVKA PRTHNRCCVT GSSGRRRKRR ESEPQRPNMS RRVFASAVLL LLVVMMCCAT
CGATAAREND GNSDLRSVEG LQWVDLFVPQ TTPVLPEGGG TPGTKRDAFA SPSLVSAGGV
IAAFARGIIN AREDGAKLIT PSYSDVVAEY IDSSWDWSTL VEKVNKGTWK AHTVLDTTDG
TNRVGVVLNP TTTTKGNKVF LLAASYDRLN QSDGIWNWDS LDLKLVVGEV TKPTASEPSG
WITWGSPTSL NQTTLKTPKA GLKYFASSGG SGVVLEDGTI VFPLMARNEA EYVYSMIIYS
TDNGSTWSLS KGVSPAKCTE PRITEWEGSI LMIVDCESEQ RVYESRDMGT TWTEAIGTLS
GVWVNPQSED YPDVSLHVEA LITATIEGRK VMLYTQRGHA SGEGNATALC LWVTDNNRSF
YFGPLAVEEA AVRWEFASGL LYSDGNLHLL QRRDNDKGRV ISLSRLTEEL KEIESVLSTW
AQNDAFFSKL SIPTAGLVAV LSDAASDDTW SDEYLCLNAT VTNATKVEDG FQLTEPDSRV
SLPVNTRGDN VRHVSLSHNF TLVASVTIEE APSEDAPLLG AIFGDTNSSH TMGILYTANK
TWETIFKGKT TKSDAWELKK EYQVALMLQG NKSSVYVDGK SLGEEEALLT DKTPLELLYF
CFGACDMKNS PVTVKNVFLY NRPLNPTEMT AIKNRIPVPT RAPEPQARGV SQTIASAVSA
VSGPEKNAAA PAVPMTLNPH AVEEVSEGGA ARRNTSRTED VQFVVPEVSL NSAGSGLLPL
FLLLGLWGFA AL
//
