ID Q4D724_TRYCC Unreviewed; 458 AA.
AC Q4D724;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 24-JAN-2024, entry version 84.
DE RecName: Full=Tetratricopeptide SHNi-TPR domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=Tc00.1047053506275.70 {ECO:0000313|EMBL:EAN88327.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN88327.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN88327.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN88327.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- SIMILARITY: Belongs to the NASP family.
CC {ECO:0000256|ARBA:ARBA00008402}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN88327.1}.
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DR EMBL; AAHK01000899; EAN88327.1; -; Genomic_DNA.
DR RefSeq; XP_810178.1; XM_805085.1.
DR AlphaFoldDB; Q4D724; -.
DR SMR; Q4D724; -.
DR PaxDb; 353153-Q4D724; -.
DR EnsemblProtists; EAN88327; EAN88327; Tc00.1047053506275.70.
DR GeneID; 3540912; -.
DR KEGG; tcr:506275.70; -.
DR eggNOG; ENOG502QQ22; Eukaryota.
DR InParanoid; Q4D724; -.
DR OrthoDB; 131505at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR15081:SF1; NUCLEAR AUTOANTIGENIC SPERM PROTEIN; 1.
DR PANTHER; PTHR15081; NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED; 1.
DR SMART; SM00028; TPR; 2.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT REPEAT 258..291
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 1..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 346..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 395..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..100
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..416
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..439
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 458 AA; 51747 MW; E2248886CFFCD68B CRC64;
MESSGQTDRS SRERREDEAT PSASDVRAGR EADFLLQRQQ QQQQEEEEKP RDRHETDAPG
SDEEGEESSS CEDECKEDND DASVVDGEDE EEEETTPFAT DEEANEARAV GIAHYNNHRY
EDALDIQYRV VRHFEKKYGA TAPICGVYFL DYGLSQLRVL QSKSTVEAAL QPLDQDALEA
CFINLDVARV CFQKQEQERG EEDIEVQLHL AEVHNSIAQL QVEREDFDSA LKEYESELMT
YRFIQEEAPQ MLPYRRLAAV LYGIADCYMK EGDFEGAEER FQAALDELAS FPADAIPAEL
VKELEELRED AREMKGGKYK ELQECIQAQF AVKEAEELPT VQEFYGEDAG NEEGGRKTHP
YVSRLPGEPE YSALSMPQSL TNPVQWNEHS NSMSLSLFPP QVNGRGSETS NSQPVHHVVA
RRKPKQPMSQ QQQQPGERGG ASSIGEPEAK RARTESCS
//
