ID Q4D7Z8_TRYCC Unreviewed; 1048 AA.
AC Q4D7Z8;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Phosphatidylinositol-4-phosphate 5-kinase-like protein, putative {ECO:0000313|EMBL:EAN88650.1};
GN ORFNames=Tc00.1047053508065.50 {ECO:0000313|EMBL:EAN88650.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN88650.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN88650.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN88650.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN88650.1}.
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DR EMBL; AAHK01000856; EAN88650.1; -; Genomic_DNA.
DR RefSeq; XP_810501.1; XM_805408.1.
DR AlphaFoldDB; Q4D7Z8; -.
DR SMR; Q4D7Z8; -.
DR STRING; 353153.Q4D7Z8; -.
DR PaxDb; 353153-Q4D7Z8; -.
DR EnsemblProtists; EAN88650; EAN88650; Tc00.1047053508065.50.
DR GeneID; 3541279; -.
DR KEGG; tcr:508065.50; -.
DR eggNOG; KOG0229; Eukaryota.
DR eggNOG; KOG0239; Eukaryota.
DR InParanoid; Q4D7Z8; -.
DR OMA; RSHTWIQ; -.
DR OrthoDB; 150198at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 2.20.110.10; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 3.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR003409; MORN.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR23084:SF262; PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE; 1.
DR PANTHER; PTHR23084; PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE RELATED; 1.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF02493; MORN; 7.
DR SMART; SM00129; KISc; 1.
DR SMART; SM00698; MORN; 7.
DR SUPFAM; SSF82185; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT DOMAIN 706..1013
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|SMART:SM00129"
FT REGION 280..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 383..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 515..579
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 607..673
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 280..297
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1048 AA; 117465 MW; 28637E1E60EF91C1 CRC64;
MLNDIETMNL LKFTSSEEMT ISMDSNKEVG GEDKVELQFP GGSKYIGSMR NGCLSGYGTY
YYASTGDKYD GHWKAGMKHG CGTYYYASGD RYVGSWYMGK KHYRGIYTFS NGDEYNGFWK
YDKIHGYGVF TIQSNGNRYE GHWKETYRHG HGVFYHGNGD VYDGNWVRGK EEGLGILIKG
TGNAYCGEWK NGEMDGKGVL RDQQFLFAVE YAKGHLVSQV PIVEGKKLQE EWSRAYDHYV
TFMGKYQRHG DKDAIEKDEL RRALEKLKIE SATWQRRYEE LRGERSTARR RSSSVPGDEG
KRLLLPNILK VPSVKAKLRP GVAAEGATRV SSLTRASFKI ADEAPATPGM TNVRRKEISP
VLPKADLDGV DCNGKEVRHV GVKKGCRATS SRSSESATPK KRNVELTEKD RELDVEHHTT
MAWEKDQLKR TIPSNLVKQE EAGQQCAEAT VSEGEASGEA TNFRDFGQQF ETTVAERTRY
DDSCGPEKNQ AQSVGNLNKR LEEVNRMNAE LNLCCDALGR KLNEQRDRYQ KLVNKTTATG
DGELLEVLKT DIQRLESQLK NAEEELRTQK AEIDSRGTRC IELESMLLNI ARKRTTDPSI
LHSLSKKMDL ARSLQESNAE LARLLEESNM KLEIIMSENK NAEGQRHSAE DSASALGEEL
RRVRKELRKE QHKSKRILAD RETVVAELHD ADIKLVGAEC ALKALQGYLT ITIRVHGCKE
GYSVPCIRIN ERDSSQIVFS EESTTQMHQF DICIDEETSL DVIFREVCRN MFTVTMGFHV
AYVTLGAIYT GKTVIFDTFV PLAINTLCNH SQRFPVDKYA LTYKVGALAI GACEAIDCET
GSTVTEIRRD AYGFTVPIGV TFVETTGADI LSTVERLRKR KPRDLRCHIW IQIQCVILHR
VRQTSTVGRL TLVDLCGPGP LPTQKEAVAS ARFANRSFGH IVAVLESLQD SQGVVQYNKS
LETALLSDVL GGNALTTIFG TLSSAVESVS ESRQTLRALT MASKVVNRPI LPRFVSSDEL
RWREVVAATS SAEVASPCLL EVDELRDM
//
