ID Q4D8V3_TRYCC Unreviewed; 2049 AA.
AC Q4D8V3;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE RecName: Full=Neurobeachin/beige protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=Tc00.1047053503781.10 {ECO:0000313|EMBL:EAN88947.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN88947.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN88947.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN88947.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN88947.1}.
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DR EMBL; AAHK01000805; EAN88947.1; -; Genomic_DNA.
DR RefSeq; XP_810798.1; XM_805705.1.
DR AlphaFoldDB; Q4D8V3; -.
DR SMR; Q4D8V3; -.
DR PaxDb; 353153-Q4D8V3; -.
DR EnsemblProtists; EAN88947; EAN88947; Tc00.1047053503781.10.
DR GeneID; 3541666; -.
DR KEGG; tcr:503781.10; -.
DR eggNOG; KOG1787; Eukaryota.
DR InParanoid; Q4D8V3; -.
DR OMA; AHYFTHY; -.
DR OrthoDB; 153443at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR CDD; cd06071; Beach; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR046851; NBCH_WD40.
DR InterPro; IPR031570; NBEA/BDCP_DUF4704.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF151; PROTEIN, PUTATIVE-RELATED; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF15787; DUF4704; 1.
DR Pfam; PF20426; NBCH_WD40; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 1216..1327
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 1345..1634
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 1821..1853
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 746..776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1157..1204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1723..1748
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 759..774
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1179..1202
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1723..1738
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EAN88947.1"
SQ SEQUENCE 2049 AA; 229942 MW; 2F04D2AEC228F9C1 CRC64;
YAAVYFSLQN MEKRTILELV ATAHSLSVIF LNEQRRTLDL DLNCSIPSQT WTQLTVVHRQ
AAFPFSGNEF LCFLNGMEVA AVSGVQYPPI SLGFFYIGTR GEDVEQRSSR RSFIGQMTAV
YFLMRALTPK EVLEFFVGGT GVTSMKQYAT HIAVYIDPRF CERGQVHNLA TLMRGKASEL
PLITYEGTVA CNTNSIIDSI CVLGALHTVV VPLLVLLVNP QLPFQCRIPP AKRKSVPETT
RKAVDDLLKL VESLLLSNTV RADVLEVGLF PMIAHVLQQF MEYHCSNLAQ RMCNLCSALL
PNGAIFDAAY TVLFLSGDLL HACSEETQLA LIKTQTAMCG ANKELCRRAH ALDLSNFVVS
EIIHVYNTSS PHHASMRREM FVLLEVMMVE PITMNDADAL LRLINFAVKQ IESMVLLEIL
ERCRVLIATR KPLLAAYMGK KDFAAVLLLL LEDSRGMVQN EALLLFCLLV GRSRRTQELL
NPTLLSAREA AHVACDISLS WLREKLHAVQ VDVGLYITLR AALTGRFDAP INDCTELKRE
DKILFAPAFT PLLQMMKRCQ EKSLKIRAMS DIAALVQQDP SAWKSVVSVP GWYASVVDLY
LSEDDLCDMQ ASDISSFLAS TTMIFVKVLF HALLHEAYGA SELELLVAYL VQQRVHVLLN
AVLTGVVKEY SALFSVRHNL LGGAHFGLGS QQAATNFTTF LFLVEDVLFY SATTYQAYGA
TRPLESLRKR GYTEEEELVL GPIKRHARDA RRQQQGEGGE EVEEEEEEEE REESVDALGG
QLFIGDKAMR FRMDPDGVWL HATLAVCTMH ILTTHAAVLN AGGTNSGGSL DFYMRGRRVR
KGGFLRLFVR LFRVTCNFIL RDAEQVEGVV LMVGRWIRIV EKEQSSFLLL RRQSTEQREH
SPLSGSMIMI LGLHDLLARR LRFSVEGSST RFEDLNYEIL DCIKCLCILY RRTLAQMQIF
HAQSPAYESA PRTRKDTLDW LCSRKRERSI VEFVEVASRQ DYDGFIRHCT LVMERDRLTE
KGIVRLIEEE HTKVMAHLHQ IITGLSVARR LMLDALEQYL QATSKELAET ETLKERFAPQ
TARKLATVVF NTVWRRFLER CKGTIWDFDP AGQHSTKYVR LLEVEQQQLV RRKLVFDSNG
TDHANITTMG SASLVLQQAE QQQPCPRGGE HMLLSTENSG NDEEDEEEEG KDEEEQMEEE
EGMELSGVAA LPVATEANQT VHFSMACEVP YMMHCWSATM VIRESDLCIF FDEENKAYNQ
RIAEEAESLL IKPGSIIYPS GHVKILAPGR RFRMRRSAVE LWFLDGMSVL INFATFPDMR
AAVNNIRTAA GRHKLLHSPL YIFQVNPKKD PMLWRRMEQW RDREISNFEY LLWLNFFGGR
TLNDITQYPV FPWVIADYTS ETLDLESPST FRDFTLPVGI CGGPQSRARV EMRYEATKQL
GDIPAHYFTH YSSSAVVLYY LIRMEPFTTL QIILQGGHFD HADRMFHSMA SCWHGVTTNS
QDVRELIPEL FYMPEICMNT NRVRFGCKQG GEAMDSLELP PWSHGDPYEF IYRMREALES
DYVSSMLHHW IDLIFGYKQR GKEAIAALNV FNWHSYEELD KNRDTDVDRQ LLIDSLDNIG
QTPIQLFTQN HVERRPYDLL DPISCSMSVK TIDVQRTCSC VARVALFASD RVLLVGGNGT
ALLFRLIVAP LTKRARRACS AGSVGSAAAT GAGENSVAAS AGSGGLPSLS NMTPSASGRG
GGISRGRPSV DMLEEVERRT APLPTGVVPN TSKKAGGPCE TENVAVLSFD NEVFVAFGGL
FDNTFVIRPL DSSSVFAEER LSAHRGRVVR ITASSNSRYI VSGAEDTTFV VWSCQLQQGR
TRLRVELLFT VYGHEDNPTA VDLSPVLDLV ATASRDGVLM LHSLTSSRLE RSLRHPENFS
IDRVLIQASC YLPNILYASA LDHVIHQIGV NGVALRSVTA PGRITSWCVT PNQYILVTTK
SFTNLNASDE SGGTVFFLHS FYLSFLNSVP CPLRSFGATL TCCAAHPSNP QVIVCGSSEG
SLSLLRVEL
//
