ID Q4DB75_TRYCC Unreviewed; 464 AA.
AC Q4DB75;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Alpha-MPP {ECO:0000256|ARBA:ARBA00030006};
GN ORFNames=Tc00.1047053508441.80 {ECO:0000313|EMBL:EAN89782.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN89782.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN89782.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN89782.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- FUNCTION: Substrate recognition and binding subunit of the essential
CC mitochondrial processing protease (MPP), which cleaves the
CC mitochondrial sequence off newly imported precursors proteins.
CC {ECO:0000256|ARBA:ARBA00002123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN89782.1}.
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DR EMBL; AAHK01000711; EAN89782.1; -; Genomic_DNA.
DR RefSeq; XP_811633.1; XM_806540.1.
DR AlphaFoldDB; Q4DB75; -.
DR SMR; Q4DB75; -.
DR STRING; 353153.Q4DB75; -.
DR PaxDb; 353153-Q4DB75; -.
DR EnsemblProtists; EAN89782; EAN89782; Tc00.1047053508441.80.
DR GeneID; 3542619; -.
DR KEGG; tcr:508441.80; -.
DR eggNOG; KOG2067; Eukaryota.
DR InParanoid; Q4DB75; -.
DR OMA; ETGRTHF; -.
DR OrthoDB; 7099at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 2.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR007863; Peptidase_M16_C.
DR PANTHER; PTHR11851; METALLOPROTEASE; 1.
DR PANTHER; PTHR11851:SF49; MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT DOMAIN 41..173
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 182..377
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
SQ SEQUENCE 464 AA; 51782 MW; 6110A9354CB214A9 CRC64;
MLRCCLPRRG IVQTVKKDNY VLSRLSNGLR VLTCDDGNGI TGMGLFMLNG TKFEDEKNTG
AAAVFESLPL RSNQIFTGRE ISEALGSLGN AFKVTNNKEA MSVMLMMPRY HQKDGLELLN
AMCLHPTRDE MEFQIAKEKT GERAGLHHRD ATSVCLELVH EAGWNGRGLG QPLDPKKEDL
DKLTLEKFTA FHRTYTRPER TVLAATGVAD HKQFAAEAEL ILSFDSETAP LGAPRKHPYT
GGSRLVQRTE APESMNKFQE KNLSHVALFC QGVPMNHPDY YNISVIQTLL GGGTSFSSGG
PGKGMQTKIF REVLNREGFL HGLECITAWY SDGGLIGLYG SAPHEYVYAL LKVMIYQAAS
ICQRVSPLHL EMAKNQLRSQ LILLGEGREQ LLSDMGFNMV VHDHIITASE TTEGTKHITI
DELKRVCDEM VQRPLTFVVY GETTKMPSHE KLEETVRKTY ERLN
//
