ID Q4DEF3_TRYCC Unreviewed; 351 AA.
AC Q4DEF3;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 120.
DE SubName: Full=NADP-dependent alcohol hydrogenase, putative {ECO:0000313|EMBL:EAN90903.1};
GN ORFNames=Tc00.1047053508677.80 {ECO:0000313|EMBL:EAN90903.1},
GN Tc00.1047053509331.210 {ECO:0000313|EMBL:EAN94936.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN90903.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN90903.1};
RX PubMed=16020724; DOI=10.1126/science.1112181;
RA El-Sayed N.M., Myler P.J., Blandin G., Berriman M., Crabtree J.,
RA Aggarwal G., Caler E., Renauld H., Worthey E.A., Hertz-Fowler C.,
RA Ghedin E., Peacock C., Bartholomeu D.C., Haas B.J., Tran A.N.,
RA Wortman J.R., Alsmark U.C., Angiuoli S., Anupama A., Badger J.,
RA Bringaud F., Cadag E., Carlton J.M., Cerqueira G.C., Creasy T.,
RA Delcher A.L., Djikeng A., Embley T.M., Hauser C., Ivens A.C.,
RA Kummerfeld S.K., Pereira-Leal J.B., Nilsson D., Peterson J., Salzberg S.L.,
RA Shallom J., Silva J.C., Sundaram J., Westenberger S., White O.,
RA Melville S.E., Donelson J.E., Andersson B., Stuart K.D., Hall N.;
RT "Comparative genomics of trypanosomatid parasitic protozoa.";
RL Science 309:404-409(2005).
RN [2] {ECO:0000313|EMBL:EAN90903.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN90903.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
RN [3] {ECO:0000313|EMBL:EAN90903.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN90903.1};
RA El-Sayed N., Bartholomeu D., Haas B.;
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|RuleBase:RU361277}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN90903.1}.
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DR EMBL; AAHK01000575; EAN90903.1; -; Genomic_DNA.
DR EMBL; AAHK01000243; EAN94936.1; -; Genomic_DNA.
DR RefSeq; XP_812754.1; XM_807661.1.
DR RefSeq; XP_816787.1; XM_811694.1.
DR AlphaFoldDB; Q4DEF3; -.
DR SMR; Q4DEF3; -.
DR STRING; 353153.Q4DEF3; -.
DR PaxDb; 353153-Q4DEF3; -.
DR EnsemblProtists; EAN90903; EAN90903; Tc00.1047053508677.80.
DR EnsemblProtists; EAN94936; EAN94936; Tc00.1047053509331.210.
DR GeneID; 3544025; -.
DR GeneID; 3548724; -.
DR KEGG; tcr:508677.80; -.
DR KEGG; tcr:509331.210; -.
DR eggNOG; KOG0023; Eukaryota.
DR InParanoid; Q4DEF3; -.
DR OrthoDB; 1550at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd05283; CAD1; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR047109; CAD-like.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR42683; ALDEHYDE REDUCTASE; 1.
DR PANTHER; PTHR42683:SF85; CINNAMYL ALCOHOL DEHYDROGENASE 6-RELATED; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 9..296
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 351 AA; 37467 MW; 176CB360FA39EB57 CRC64;
MATNAKGYAA PSAKAPLAPF SFQRRAVGAD DVSIKILFCG VCHSDIHQAR DEWGGSLFPM
VPGHEIVGHV TSVGANVKKF KVGDTVGVGC MVDSCERCVE CKRGLEQFCV EGTTSTYNSR
ARVSGEPTYG GYSDHIVVKE SFVLLIPSNL DLAATAPLLC AGITTYSPLR HWGTKAGTRV
GVVGLGGLGH MAVKIAKAMG AEVTVFTTSE GKREAARMLG ADHVVISKDP GQMRAVKNTL
NLIIDTVGNT HDLSPYILAL TTDGVHILVG LPENPHPPVS PFLLLKGRKS IGASLIGGIP
ETQEMLDFCG RHGIVSDIEL ISIDYINTAY ERVMKSDVRY RFVIDMATLG Q
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