ID Q4DID1_TRYCC Unreviewed; 557 AA.
AC Q4DID1;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=GTP-ase activating protein, putative {ECO:0000313|EMBL:EAN92287.1};
GN ORFNames=Tc00.1047053506959.100 {ECO:0000313|EMBL:EAN92287.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN92287.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN92287.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN92287.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN92287.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAHK01000447; EAN92287.1; -; Genomic_DNA.
DR RefSeq; XP_814138.1; XM_809045.1.
DR AlphaFoldDB; Q4DID1; -.
DR SMR; Q4DID1; -.
DR STRING; 353153.Q4DID1; -.
DR PaxDb; 353153-Q4DID1; -.
DR EnsemblProtists; EAN92287; EAN92287; Tc00.1047053506959.100.
DR GeneID; 3545631; -.
DR KEGG; tcr:506959.100; -.
DR eggNOG; KOG0703; Eukaryota.
DR InParanoid; Q4DID1; -.
DR OMA; CIGVHRK; -.
DR OrthoDB; 119920at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR InterPro; IPR044518; ARF_GAP_AGD11/12/13.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR PANTHER; PTHR46220; ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN AGD12; 1.
DR PANTHER; PTHR46220:SF1; ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN AGD12; 1.
DR Pfam; PF01412; ArfGap; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR PROSITE; PS50115; ARFGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 239..363
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT COILED 197..233
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 557 AA; 62512 MW; 659ABFBC3641FB87 CRC64;
MMEATLETLL LSGAVSCRFI WRKRQKVMRT IEIHTDGVLY CFDEPKDSMA KNLRERLYLF
GSRVVDCGTH RGRLCFGLEL ADASSVEQLR PSGLFTSLRT SAPVSPLKNE GSLSKIFVAF
FFVGNKLLKW RFIHLLRLAS SASPPFLALQ QQEPNLALSA SCGSHENDDS RGIYRILERP
PRIIDVTGDG PLEMHEVEQL EDVLRLYEEN KRLKQEEEEN NDEEESLRES VVTCDDDKME
VPERLMQSPL YAPCIADRPS NQICADCGEK WPTWAVLGPF GCFVCIHCVG VHRQLRPHCC
REVQLDNWDA AEIDFMAKRG NDIVNDELEY AGFFLGSGVA VYKPVGSSSR REVREEYITL
KYEGAFTRER NPHVLQAMLP PPDRDVQGHL DISKHGALNH DGPPQYIGVA YINVREVEGI
RSSGAVLSLT NGFQEVRSRA GVVPSGPAKN NPCHACTCWE ESFQLGVYSV TAPLFMALYT
SGDELLGAAE WRLPDGVALP GSEPQLVKVP LFWCLPAEGS TWPTFNPFGG GRRHRKRGAE
KWHQPLLYIT VSFAHFG
//
