ID Q4DL52_TRYCC Unreviewed; 834 AA.
AC Q4DL52;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=Tc00.1047053509029.120 {ECO:0000313|EMBL:EAN93260.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN93260.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN93260.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN93260.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN93260.1}.
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DR EMBL; AAHK01000365; EAN93260.1; -; Genomic_DNA.
DR RefSeq; XP_815111.1; XM_810018.1.
DR AlphaFoldDB; Q4DL52; -.
DR SMR; Q4DL52; -.
DR STRING; 353153.Q4DL52; -.
DR PaxDb; 353153-Q4DL52; -.
DR EnsemblProtists; EAN93260; EAN93260; Tc00.1047053509029.120.
DR GeneID; 3546753; -.
DR KEGG; tcr:509029.120; -.
DR eggNOG; KOG2108; Eukaryota.
DR InParanoid; Q4DL52; -.
DR OMA; YAQREKS; -.
DR OrthoDB; 208346at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT DOMAIN 32..341
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 336..734
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 227..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..251
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 53..60
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 834 AA; 92544 MW; 3D17C48789D5FB95 CRC64;
MGLDGGVAVP AAVSGAQRGE ECAAECERLV SALDEAQRAA VCEDTSASLL ILAGAGSGKT
LTMASRIAYI ILTGVAAEKI LGLCFSRQAA EALRERVATV LPPSMAAHVQ RLKLKTFHAF
GLECLRRHGC IDLATEVYDA RRQRELASAV VEAYAVHHKG LEAVLALVEY VNKAKTKKDM
RAGTEIDPSR QAAYLFRFYQ AMLHEQHNAV DFGDLEQMFL ETLRPVGRQE QPSEEGVEGN
GGSNSNSLMS VVPPPRLPSP VALQLRAQYT HIVVDEFQDL NEVQLECLAL LAGDTCRVTC
VGDPNQCIYT WRGATTNSFE RWRSRFPQTK IVTLGTNYRS SEEIVSAVNA VSQISQQSFR
GECGRRIILI RCPHAWEQMS LLPRVVEELL RTRDRGLKYS DIAILCRTRR TVRDVVTALE
REQIPVCELR PSRPNSKALV RAMLSYLRLC VHPHSNLDVE CVIRDAPNHF SAAAATKFIF
AMQAECLQRR RELSTAKLQC EDSHATYSYY TILRELVHNG FAHVHERLRT TKPQQKFLRN
FIEVTTAAHD ALGRMYCDIE EVVRDVAERA GFDGGSATSV QIRRRPCCGI KRRRSSAPLR
RSAAIWDDVM GDAEDEVGVM EEEGDAMSIS QVLVEASRTV QQQVLVEKKN VDSSQERYGE
IKNGENDMGD AASAVKAEAK VQNDAYTVLQ RVIDEFLALL PTDDFGPLKG GSNVKMESTQ
VPRVTVTTVH QAKGKEWLSV IVPCCYEGEF PIDVKRAEER RVFYVAMSRA MRDLVLMTAE
FGSLAPRDYD DGNGAVGGAE QPLHITPYLR PLMPFMETLS MTSQEQLKGG NVGS
//
