ID Q4DR62_TRYCC Unreviewed; 869 AA.
AC Q4DR62;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 112.
DE RecName: Full=Palmitoyltransferase {ECO:0000256|RuleBase:RU079119};
DE EC=2.3.1.225 {ECO:0000256|RuleBase:RU079119};
GN ORFNames=Tc00.1047053504033.220 {ECO:0000313|EMBL:EAN95027.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN95027.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN95027.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN95027.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-
CC hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-
CC COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151;
CC EC=2.3.1.225; Evidence={ECO:0000256|RuleBase:RU079119};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- DOMAIN: The DHHC domain is required for palmitoyltransferase activity.
CC {ECO:0000256|RuleBase:RU079119}.
CC -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
CC {ECO:0000256|RuleBase:RU079119}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN95027.1}.
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DR EMBL; AAHK01000237; EAN95027.1; -; Genomic_DNA.
DR RefSeq; XP_816878.1; XM_811785.1.
DR AlphaFoldDB; Q4DR62; -.
DR SMR; Q4DR62; -.
DR STRING; 353153.Q4DR62; -.
DR PaxDb; 353153-Q4DR62; -.
DR EnsemblProtists; EAN95027; EAN95027; Tc00.1047053504033.220.
DR GeneID; 3548835; -.
DR KEGG; tcr:504033.220; -.
DR eggNOG; KOG1315; Eukaryota.
DR eggNOG; KOG4177; Eukaryota.
DR InParanoid; Q4DR62; -.
DR OMA; PLRAQYC; -.
DR OrthoDB; 131049at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001594; Palmitoyltrfase_DHHC.
DR PANTHER; PTHR24161; ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR24161:SF85; LD20463P-RELATED; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01529; DHHC; 1.
DR SMART; SM00248; ANK; 5.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS50216; DHHC; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU079119};
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Membrane {ECO:0000256|RuleBase:RU079119};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|RuleBase:RU079119};
KW Transmembrane {ECO:0000256|RuleBase:RU079119};
KW Transmembrane helix {ECO:0000256|RuleBase:RU079119}.
FT TRANSMEM 406..430
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 480..499
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 577..599
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT TRANSMEM 619..639
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU079119"
FT REPEAT 76..127
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 128..160
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 270..302
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 537..654
FT /note="Palmitoyltransferase DHHC"
FT /evidence="ECO:0000259|Pfam:PF01529"
FT REGION 727..746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 869 AA; 95494 MW; 7AF94645D23DDF4B CRC64;
MQVFGARMAS RGGRTLPLTY FMQSELTTAE EAPPVDVFTA KLGNRTFHES LRNDSGFAIV
TAFLLGGVDV NVRDKNGATP LHVAVSRAAP TPGNDDDESV LLSSEGPNNL IISFLIDNGA
DINSRNATGE TPLMIAAATQ NISALRIILS RGADTSLRDD IGNTVLHHAA CHPHVLQTLH
SWIDDLPAQA ARENLLHMVC RQGRGAEFAA LFLIEQLGVD VNVREGETAA TTGVHDADHH
YRPIEANTAT TTAAIQRCDS APHSGVIVKE GRTPLHCAVL VGDTLLLRLL LLKGADVEKP
DATGRTPIQL ANDCAMSSSP SLLTSLLSFI RFQCSFLGLT QRNGRTAKNI DPWKVYTILD
AHSKEASSAK REANLQREAA ADTSLWRLNT ISDILSFGAA AALPHFLMAL CALMGMPLWI
LIVFATIELI SCNGFKVKDE RRLNVRPLRS VGFLVGYTLV LLACSISLED AMEPRRMNTR
PWLFLCTIGS SLCAFLVMWM DPGIVESTAG QRVGIYKTIF YTKGAPPEDV RQGIDLSCMV
KKPLRAQRCR HLGRVVLRYD HYCTWLASAI GGGNHRLYIA FLLFYTVLLG ICCRSTYWLS
PKQMNNEMFL DDLHFRRFAN VYILFVLPVA FIFSLYTLLQ QLWYIARGVT AYDVAQPSRC
PWCFQLGSRT YSLFDAGFWR NVCGFFFLRE KFLNISYRMP VMSARLQKMA KRHQALQLSS
CHDGHCHSHE NGGHGHSHNG HLGQLHQYNP QQRSNAPLNT ALSNVAEGIG SPATTAVVIN
SSTPASALAS DPFPSLAVDT TAAATQLGFE ASVGRLFQLM VQHGDTDLTA VAAANEIRAS
VLPEKWLEIV EKAQSMYGFF KSTMNNANN
//