ID Q4DTM3_TRYCC Unreviewed; 680 AA.
AC Q4DTM3;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE SubName: Full=Heat shock protein 70, putative {ECO:0000313|EMBL:EAN95892.1};
GN ORFNames=Tc00.1047053511211.220 {ECO:0000313|EMBL:EAN95892.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN95892.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN95892.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN95892.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC {ECO:0000256|RuleBase:RU003322}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN95892.1}.
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DR EMBL; AAHK01000184; EAN95892.1; -; Genomic_DNA.
DR RefSeq; XP_817743.1; XM_812650.1.
DR AlphaFoldDB; Q4DTM3; -.
DR SMR; Q4DTM3; -.
DR STRING; 353153.Q4DTM3; -.
DR PaxDb; 353153-Q4DTM3; -.
DR EnsemblProtists; EAN95892; EAN95892; Tc00.1047053511211.220.
DR GeneID; 3549805; -.
DR KEGG; tcr:511211.220; -.
DR eggNOG; KOG0101; Eukaryota.
DR InParanoid; Q4DTM3; -.
DR OMA; IQINVTH; -.
DR OrthoDB; 168423at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR Gene3D; 3.30.30.30; -; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR018181; Heat_shock_70_CS.
DR InterPro; IPR029047; HSP70_peptide-bd_sf.
DR InterPro; IPR013126; Hsp_70_fam.
DR PANTHER; PTHR19375; HEAT SHOCK PROTEIN 70KDA; 1.
DR PANTHER; PTHR19375:SF515; SHOCK PROTEIN 70, PUTATIVE-RELATED; 1.
DR Pfam; PF00012; HSP70; 1.
DR PRINTS; PR00301; HEATSHOCK70.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR SUPFAM; SSF100920; Heat shock protein 70kD (HSP70), peptide-binding domain; 1.
DR PROSITE; PS00297; HSP70_1; 1.
DR PROSITE; PS00329; HSP70_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU003322};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003322};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Stress response {ECO:0000313|EMBL:EAN95892.1}.
FT REGION 621..680
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 635..649
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 665..680
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 680 AA; 73714 MW; 686ED0D49D7A1AA1 CRC64;
MEEFDGTIGI DLGTTYSCVA VFRSDAVEVI PNDQGNRTTP SCVAFHNGDV LVGDSAKQLA
SRGVTGVVYD AKRMIGRKFG EKTIHDDVKR WPFAVEKGEN DGVLIRVEHN GETLRLEPEQ
ISARVLAYLK LCAEQFIGKR VKKAVITVPA YFNDAQRERT RAAARIAGLE VLRIVNEPTA
AALCYGLGLG SGAGAQGADC PVNVLVFDFG GGTFDVSIIA IDNGSFAVRS TAGDTHLGGQ
DVDTELLRYV LNDLKNRHGV DATSQPRLLA KLLARCEQAK RVLSHATTEE IVMDGILTGG
EEYALSLSRA KLEELCAKIF ARCMAVVQKA MKDAAVTPDD IDDVILVGGS SRIPALRVML
QEMFKGKRLC SSVHPDEAVA IGAAVQASII STSAEQQSEK TANVVLMDVV PLSIGVEVDD
GKFDVIIRRN TTIPYCATKE YSTVEDNQDE VEVQVFEGER PLTRHNHKLG AFILDGISRA
KKGDPTITVT FSVDADGILT ITASEELANV KKTLIVENTE RLSDEAVQKM IEVAQKFSAK
DAVAVSIMDA TQRLTSGFTE LETALAAMPL PLSKKLQRHV AFLTHGKQWL EQQLPNYTET
HAVDVKTTKI MKLVQKAMKT LQRESRKGTE NNNESDSGSD DDDDTNENDG DALGGSGGST
PRDSSTGRKR MRSNPRNDEG
//
