ID Q4DWY5_TRYCC Unreviewed; 725 AA.
AC Q4DWY5;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Trans-sialidase, putative {ECO:0000313|EMBL:EAN97045.1};
DE Flags: Fragment;
GN ORFNames=Tc00.1047053510197.229 {ECO:0000313|EMBL:EAN97045.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN97045.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN97045.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN97045.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN97045.1}.
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DR EMBL; AAHK01000118; EAN97045.1; -; Genomic_DNA.
DR RefSeq; XP_818896.1; XM_813803.1.
DR AlphaFoldDB; Q4DWY5; -.
DR SMR; Q4DWY5; -.
DR PaxDb; 353153-Q4DWY5; -.
DR EnsemblProtists; EAN97045; EAN97045; Tc00.1047053510197.229.
DR GeneID; 3551240; -.
DR KEGG; tcr:510197.229; -.
DR eggNOG; ENOG502SNPZ; Eukaryota.
DR InParanoid; Q4DWY5; -.
DR OrthoDB; 132268at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011040; Sialidase.
DR InterPro; IPR026856; Sialidase_fam.
DR InterPro; IPR036278; Sialidase_sf.
DR InterPro; IPR008377; Sialidase_trypan.
DR PANTHER; PTHR10628; SIALIDASE; 1.
DR PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR Pfam; PF13859; BNR_3; 1.
DR PRINTS; PR01803; TCSIALIDASE.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50939; Sialidases; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 96..455
FT /note="Sialidase"
FT /evidence="ECO:0000259|Pfam:PF13859"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 165..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..37
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 725
FT /evidence="ECO:0000313|EMBL:EAN97045.1"
SQ SEQUENCE 725 AA; 78848 MW; 08F4115A8C84B18D CRC64;
MLSRVAAVKA PRTHNRRRVT GSSGRRREGR ESEPQRSKMS RHLFYSAVLL LFFVMICCGT
GSASSKEKSP VQIPPPKTYF DWRDVKVEET VSSLRVPSLL KVNGDVFAVA EALCTGKKDT
GEGSFTGIAS EVLELTGENP KEELGKNKLK TQVLEECTFE GGNCPSQNAA EEGGSRSQTT
VHVSRPTTVV EGSDIYMLAG SYSWTLTADD QAGGWGLMLV KGNVSTVDSK KRIYWSDTYG
LPWSYKVKQN EPLMRLVGSG GSGVQLEDGT LVFPLEGTKK LNGAAEDGKT TTVSLIIHSV
KDIASWKLSE GMSADGCGDP SVVEWEKDKL MMMTACDDGR RRVYESGDKG ESWTEALGTL
SRVWGNKKGV KVELVGSGFI TAKIGDDRDV MLVTLPVYSS KDGNGKGVLH LWLTDNTHIV
DIGPVSEKEE EDVTASSLLY KSVEGKKDEL IALYEKKKGV EETSSGMVSV RLTAQLQRVK
KVLATWKKAD ERVSQLCTSE SVGRDTLTGT ACSADIKITD GLVGFLSGNF SENTWRDEYL
GVNATLDNEG VEQVETGVKF KGRGAGAEWP VGKQGDNQLY HFANYNFTLV ATVSIDGEPT
EGNIPLLGVL LDGEKKTTLM ELSYDREKKW ILLCGGETHK KHSSTWDPET TKKHHVVILL
RNGNQSSAYV DGKRVGEDVP CALGNTDSKV ISHFYIGGDG KSAVSPGNGE DVSVTVTNVL
LYNRP
//
