ID Q4DX72_TRYCC Unreviewed; 553 AA.
AC Q4DX72;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=Dynein regulatory complex subunit 3 {ECO:0000256|ARBA:ARBA00040950};
GN ORFNames=Tc00.1047053506945.280 {ECO:0000313|EMBL:EAN97140.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN97140.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN97140.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN97140.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme
CC {ECO:0000256|ARBA:ARBA00004611}.
CC -!- SIMILARITY: Belongs to the DRC3 family.
CC {ECO:0000256|ARBA:ARBA00038378}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN97140.1}.
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DR EMBL; AAHK01000113; EAN97140.1; -; Genomic_DNA.
DR RefSeq; XP_818991.1; XM_813898.1.
DR AlphaFoldDB; Q4DX72; -.
DR SMR; Q4DX72; -.
DR STRING; 353153.Q4DX72; -.
DR PaxDb; 353153-Q4DX72; -.
DR EnsemblProtists; EAN97140; EAN97140; Tc00.1047053506945.280.
DR GeneID; 3551330; -.
DR KEGG; tcr:506945.280; -.
DR eggNOG; KOG0531; Eukaryota.
DR InParanoid; Q4DX72; -.
DR OMA; SFMEMMT; -.
DR OrthoDB; 24160at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45973:SF12; DYNEIN REGULATORY COMPLEX SUBUNIT 3; 1.
DR PANTHER; PTHR45973; PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED; 1.
DR Pfam; PF14580; LRR_9; 1.
DR SMART; SM00365; LRR_SD22; 5.
DR SMART; SM00369; LRR_TYP; 4.
DR SUPFAM; SSF52075; Outer arm dynein light chain 1; 1.
DR PROSITE; PS51450; LRR; 4.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00022846};
KW Cilium {ECO:0000256|ARBA:ARBA00022846};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Flagellum {ECO:0000256|ARBA:ARBA00022846};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000002296};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
SQ SEQUENCE 553 AA; 64528 MW; 1635A96261534877 CRC64;
MSKGYTVVSV MKQTQETVIN ESLIRDCIYL PPACTTEEER LRFVGVREEN QRHQRVKTTM
ETMELHKVTT LLASYRRIGK IENLVGLCNL TKLALDNNNI SVVCNLGHLK KLQWLDLSFN
QITEICGLED LVELETLSLF SNNISVIQGL ETLKKLTSLS LGNNRIEALE DAARYLHRLG
SLRILTLKGN RVEKQPHYKL RLLAFVPTLQ FLDGCVIDPN EVVSAREEQR ENLMPVDEED
ERAAEVAKVE QELEKARKDY ERFNCPDETN FYDELFHLEL DGRGVVELLR VDIIASLSKE
LLEKYQMEFT EKARELTEAM KAIRTRRDED ESAFNTASAR YRQKNADACK AIIKQFEKEV
KAHIPRTMWC REVDTGAIPS EVLSQLQIRL REVRHQLLEK EADQYDALES LNAGTIGKWK
GDGIDVILQT AFENFLKMEA DFQVALRQLF DSVFEMRQKQ EHATDSYHLI KQDESIMAII
DNKEDYQKFL GDWFELRRKR LEEMEQMYIS NEEKLLRERS TRILDEEQSR HRARLNEIHE
FVEQMKGLLE CAW
//
