ID Q4E0D8_TRYCC Unreviewed; 837 AA.
AC Q4E0D8;
DT 13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Calpain-like cysteine peptidase, putative {ECO:0000313|EMBL:EAN98249.1};
GN ORFNames=Tc00.1047053508999.190 {ECO:0000313|EMBL:EAN98249.1};
OS Trypanosoma cruzi (strain CL Brener).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=353153 {ECO:0000313|EMBL:EAN98249.1, ECO:0000313|Proteomes:UP000002296};
RN [1] {ECO:0000313|EMBL:EAN98249.1, ECO:0000313|Proteomes:UP000002296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CL Brener {ECO:0000313|EMBL:EAN98249.1,
RC ECO:0000313|Proteomes:UP000002296};
RX PubMed=16020725; DOI=10.1126/science.1112631;
RA El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G.,
RA Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G.,
RA Westenberger S.J., Caler E., Cerqueira G.C., Branche C., Haas B.,
RA Anupama A., Arner E., Aslund L., Attipoe P., Bontempi E., Bringaud F.,
RA Burton P., Cadag E., Campbell D.A., Carrington M., Crabtree J., Darban H.,
RA da Silveira J.F., de Jong P., Edwards K., Englund P.T., Fazelina G.,
RA Feldblyum T., Ferella M., Frasch A.C., Gull K., Horn D., Hou L., Huang Y.,
RA Kindlund E., Klingbeil M., Kluge S., Koo H., Lacerda D., Levin M.J.,
RA Lorenzi H., Louie T., Machado C.R., McCulloch R., McKenna A., Mizuno Y.,
RA Mottram J.C., Nelson S., Ochaya S., Osoegawa K., Pai G., Parsons M.,
RA Pentony M., Pettersson U., Pop M., Ramirez J.L., Rinta J., Robertson L.,
RA Salzberg S.L., Sanchez D.O., Seyler A., Sharma R., Shetty J., Simpson A.J.,
RA Sisk E., Tammi M.T., Tarleton R., Teixeira S., Van Aken S., Vogt C.,
RA Ward P.N., Wickstead B., Wortman J., White O., Fraser C.M., Stuart K.D.,
RA Andersson B.;
RT "The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas
RT disease.";
RL Science 309:409-415(2005).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00239}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN98249.1}.
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DR EMBL; AAHK01000064; EAN98249.1; -; Genomic_DNA.
DR RefSeq; XP_820100.1; XM_815007.1.
DR AlphaFoldDB; Q4E0D8; -.
DR SMR; Q4E0D8; -.
DR PaxDb; 353153-Q4E0D8; -.
DR EnsemblProtists; EAN98249; EAN98249; Tc00.1047053508999.190.
DR GeneID; 3552672; -.
DR KEGG; tcr:508999.190; -.
DR eggNOG; KOG0045; Eukaryota.
DR InParanoid; Q4E0D8; -.
DR OMA; VKLRNAW; -.
DR OrthoDB; 142935at2759; -.
DR Proteomes; UP000002296; Unassembled WGS sequence.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00044; CysPc; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR022684; Calpain_cysteine_protease.
DR InterPro; IPR015232; DUF1935.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR InterPro; IPR036310; Smp-1-like_sf.
DR PANTHER; PTHR47047:SF4; CYSTEINE PEPTIDASE, PUTATIVE CYSTEINE PEPTIDASE, CLAN CA, FAMILY C2, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR47047; PUTATIVE-RELATED-RELATED; 1.
DR Pfam; PF09149; DUF1935; 1.
DR Pfam; PF00648; Peptidase_C2; 1.
DR PRINTS; PR00704; CALPAIN.
DR SMART; SM00230; CysPc; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF101601; Smp-1-like; 1.
DR PROSITE; PS50203; CALPAIN_CAT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002296}.
FT DOMAIN 332..641
FT /note="Calpain catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50203"
FT REGION 1..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..52
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..143
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 569
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1"
FT ACT_SITE 591
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1"
SQ SEQUENCE 837 AA; 95767 MW; 8849BFCC1F0B0D47 CRC64;
MSAENQWEEL EDLPQQNKEA SAEIDNDLQD GSHSDADKAN GEVGEIQETS EYPVEKAEAN
NQPEFCDQEV QEPRPHPPEE EYPAEEPNTY PEEEPHNEEV NKREVPVEEG VVRGENKESN
EDEFPPHTQE VHHLVKPRKT PLKKPTRWDP IEYDLREDSD DEFEMATALR PVYEEEEEFG
VPKFKNGEPD YQGEYLSCFD EPNLLYRILN REEKTWAFYN DTRHYEMHVR FIFGKNSVLE
ALGNTKIHTR SDGEHVAEVF VYPGETEMFI KGRVNGFTSK LRAVPLSEEY HQRRQEVAED
AIQREVAQIK AIVGDERSAE KVLEACLENN LPFVDLEFPP CQASLDTGAK KPFKHLPWAR
PSSYLPDELL DQVRLFRGPI RPSSIDQGEL GDAWLMCSIA AISENPQSIL KMFRHPVSAE
IGRKERAIGA YRVTFNKNGL WRSVIVDNYL PISGGKPKYA KSTHDLAEIW PSILEKAFAK
LHGSYAHICS GDPLHAIQDL TGYSYCRFDD AFTKASQSGK DDLFQDWLKY NKAHYQMMLS
TPGKDPNDKG SSDPKLVKLY QSVGLISGHA YTVLDTQYFA DHELRLVKLR NAWGRTAEWN
GDWCGDDEKW EQYPDVAEAC KFQKDDNSAF WMSWEACLYY FNGGGVSFSH PSLNDYRVPS
KFVECTPSCV LEVSVEQPTW ICFTISQQDR RGRQDAVEYQ PVMLSIAQPF EKGLYKVVQN
SSADAYSPSC DKWIFLQARD VSLIHKFLPE HSPYLVIPRL MSMTGQEGEV PYALGFSCNR
VVGHDGVTVQ FKALDKENKV MHNFPKFDPE ATPVVVDYQV KSPHKGYPEM KQGQTVY
//