ID Q4FKS8_TRYB2 Unreviewed; 482 AA.
AC Q4FKS8;
DT 30-AUG-2005, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2005, sequence version 1.
DT 22-FEB-2023, entry version 49.
DE SubName: Full=Nucleoside transporter 1, putative {ECO:0000313|EMBL:CAJ16333.1};
GN ORFNames=Tb09.v4.0106 {ECO:0000313|EMBL:CAJ16333.1};
OS Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=185431 {ECO:0000313|EMBL:CAJ16333.1};
RN [1] {ECO:0000313|EMBL:CAJ16333.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=927/4 GUTat10.1 {ECO:0000313|EMBL:CAJ16333.1};
RA Lennard N., Barron A., Clark L., Corton C., Harris B., Line A.,
RA Berriman M., Hertz-Fowler C., Renauld H., Bohme U., Arrowsmith C.,
RA Cronin C., Davies R., Doggett J., Fraser A., Johnson D., Larke N.,
RA Leech V., Lord A., MacLeod A., Norbertczak H., Ormand D., Quail M.,
RA Rabbinowitsch E., Rajandream M., Reitter C., Sharp S., Woodward J.,
RA Hall N., Melville S.and.Barrell.B.;
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
CC {ECO:0000256|ARBA:ARBA00007965}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CT009751; CAJ16333.1; -; Genomic_DNA.
DR AlphaFoldDB; Q4FKS8; -.
DR VEuPathDB; TriTrypDB:Tb09.v4.0106; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005337; F:nucleoside transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR002259; Eqnu_transpt.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR10332; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER; 1.
DR PANTHER; PTHR10332:SF82; TRANSPORTER 2, PUTATIVE-RELATED; 1.
DR Pfam; PF01733; Nucleoside_tran; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 98..117
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 129..150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 162..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 204..223
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 319..340
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 352..372
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 384..407
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 413..437
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 449..472
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 247..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 482 AA; 52881 MW; 8C9686D2B03AB7BD CRC64;
MLGFGSVHEL LAYITFMCFG MSVMVVSNTV LSFLEFFLQF YLFAAKDGEN IKLETEEQKF
FWKNVFTYYL ATTFIVECLV VSLMLTNFGK RIPITLRLYI GLVFPIILVF SVMMVTIGKT
TETGARVTII LIGLINGAST ALCSSCAVAL AGPFPTKFLS AYVWGVSVCG VITSTFAIVI
KASTESNFKR TEDRVASRLT QSRIYFGLVM IMQSISCGLL LLLRKNPYAM KYTADFRYAA
RKGNAVEGDD AGDDNEPSSL GKGPADQDDD LKADCKAGKS NVMTSTVDPD TMRDTDQVEN
ITNSQQMLKA SALSVFRRVW PMLAVCFIAF FTAFLIYPGV FFAVKLGPDD NGWYMVIIPM
MFNLGDFVAR LFVQFKTLHA SPLFVVIGTF ARLLLVIPIV LCAYSVIKGT TFPYILCFLW
SLTYGYVGGL AGVYAPRTGS LTTAGERSLA ANWAVSSLLF GIFAGCTCAL GVNSALPKNE
SQ
//
