ID Q4H3F9_CIOIN Unreviewed; 602 AA.
AC Q4H3F9; A0A1W2VPM7;
DT 30-AUG-2005, integrated into UniProtKB/TrEMBL.
DT 30-AUG-2005, sequence version 1.
DT 08-NOV-2023, entry version 93.
DE RecName: Full=Frizzled-4 {ECO:0000256|ARBA:ARBA00018149};
GN Name=Ci-Fz4 {ECO:0000313|EMBL:BAE06468.1};
OS Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis).
OC Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia;
OC Cionidae; Ciona.
OX NCBI_TaxID=7719 {ECO:0000313|EMBL:BAE06468.1};
RN [1] {ECO:0000313|EMBL:BAE06468.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12736827; DOI=10.1007/s00427-003-0330-z;
RA Satou Y., Satoh N.;
RT "Genomewide surveys of developmentally relevant genes in Ciona
RT intestinalis.";
RL Dev. Genes Evol. 213:211-212(2003).
RN [2] {ECO:0000313|EMBL:BAE06468.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15269171; DOI=10.1242/dev.01270;
RA Imai K.S., Hino K., Yagi K., Satoh N., Satou Y.;
RT "Gene expression profiles of transcription factors and signaling molecules
RT in the ascidian embryo: towards a comprehensive understanding of gene
RT networks.";
RL Development 131:4047-4058(2004).
RN [3] {ECO:0000313|EMBL:BAE06468.1}
RP NUCLEOTIDE SEQUENCE.
RA Satou Y.;
RT "Expressed genes in Ciona intestinalis.";
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000256|ARBA:ARBA00008077}.
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DR EMBL; AB210463; BAE06468.1; -; mRNA.
DR RefSeq; NP_001071724.1; NM_001078256.1.
DR AlphaFoldDB; Q4H3F9; -.
DR GeneID; 100177470; -.
DR KEGG; cin:100177470; -.
DR CTD; 31659; -.
DR OrthoDB; 5483535at2759; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd07448; CRD_FZ4; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR000539; Frizzled/Smoothened_7TM.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR041765; FZ4_CRD.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF23; FRIZZLED-4; 1.
DR Pfam; PF01534; Frizzled; 1.
DR Pfam; PF01392; Fz; 1.
DR PRINTS; PR00489; FRIZZLED.
DR SMART; SM00063; FRI; 1.
DR SMART; SM01330; Frizzled; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 2: Evidence at transcript level;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:BAE06468.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 228..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 262..282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 325..342
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 354..373
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 393..421
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 442..465
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 485..504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 51..172
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 226..511
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT DISULFID 56..117
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 64..110
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 101..139
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 128..169
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 132..156
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 602 AA; 68763 MW; 8EDB1F73AB0E0BE4 CRC64;
MEIRQTSTYF VAFRLVLTAL IAAEFVSSNR SYKLPTSKYD RRLPSDPIFD EDDNRCEPIQ
IKMCQGLGYN ATRMPNRFGQ YRQTEAGIEL NSYQVLLQYN CSSELPMFLC AAFLPMCEPG
LERTIGPCEG MCLSIKKLCL PALKSFGYPW PEILNCSNFP KDNKQNMMCM TGTHPHVKDE
QPLIRPTKIK RSYCRQPQIS LQSNEGCGWR CGYQQGMFST EDKEFADLWM GVCSGVCFIS
TVFTVLTFLI DASRFRYPER PIILIAMCYN IYSISYILRL LVGRNNISCQ RNTEGEMFLI
KEGLGNTGCT VVFLLSYFFG MASYLWWVIL TLTWFLAAGM KWSHEAIERH SSYFHLVAWS
IPSIKIVIIL ILRHVDGDEL TGMCYVGNQD MNALTGFVLA PLFTYLVIGT SFLLAGFFSL
FRIKSYMEKE GSKTDKLERL MVKIGVFSVL YIVPASIVIG CYFYEHAVRR LWAQNRNVTP
SATIYFLRIL MQLIIGVFTG FWVWSKKSMQ SWRQCSHSVL ALSPKHQLKQ TIDNRATCVT
SQHKLPDVIT PQECIPTHCP HTGHPLFVAM PTSSGAFSRT YRFEGKIQEP LLLSNNRVEG
IP
//
