ID Q4K004_STREE Unreviewed; 455 AA.
AC Q4K004;
DT 02-AUG-2005, integrated into UniProtKB/TrEMBL.
DT 18-APR-2006, sequence version 2.
DT 13-SEP-2023, entry version 29.
DE SubName: Full=Undecaprenylphosphate glucosephosphotransferase WchA (Initial sugar transferase) {ECO:0000313|EMBL:CAI34052.2};
GN Name=wchA {ECO:0000313|EMBL:CAI34052.2};
GN ORFNames=SPC28F_0008 {ECO:0000313|EMBL:CAI34052.2};
OS Streptococcus pneumoniae.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=1313 {ECO:0000313|EMBL:CAI34052.2};
RN [1] {ECO:0000313|EMBL:CAI34052.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=34372 {ECO:0000313|EMBL:CAI34052.2};
RX PubMed=16532061; DOI=10.1371/journal.pgen.0020031;
RA Bentley S.D., Aanensen D.M., Mavroidi A., Saunders D., Rabbinowitsch E.,
RA Collins M., Donohoe K., Harris D., Murphy L., Quail M.A., Samuel G.,
RA Skovsted I.C., Kaltoft M.S., Barrell B., Reeves P.R., Parkhill J.,
RA Spratt B.G.;
RT "Genetic analysis of the capsular biosynthetic locus from all 90
RT pneumococcal serotypes.";
RL PLoS Genet. 2:262-268(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the bacterial sugar transferase family.
CC {ECO:0000256|ARBA:ARBA00006464}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CR931693; CAI34052.2; -; Genomic_DNA.
DR AlphaFoldDB; Q4K004; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR InterPro; IPR003362; Bact_transf.
DR InterPro; IPR017475; EPS_sugar_tfrase.
DR NCBIfam; TIGR03025; EPS_sugtrans; 1.
DR PANTHER; PTHR30576; COLANIC BIOSYNTHESIS UDP-GLUCOSE LIPID CARRIER TRANSFERASE; 1.
DR PANTHER; PTHR30576:SF10; SLL5057 PROTEIN; 1.
DR Pfam; PF02397; Bac_transf; 1.
DR Pfam; PF13727; CoA_binding_3; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CAI34052.2};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 9..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 33..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 63..88
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 100..121
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 264..288
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 262..449
FT /note="Bacterial sugar transferase"
FT /evidence="ECO:0000259|Pfam:PF02397"
SQ SEQUENCE 455 AA; 52150 MW; 29CC9DE9A86BD1F3 CRC64;
MNGKILRSSL AIIQSFLVIL LTYLLSAVRE TEIVSTTAIA LYILHYFVFY ISDYGQDFFK
RRYLIELVQT LKYILFFALA ISISNFFLED RFSISRRGMI YFLTLHALLV YVLNLFIKWY
WKRAYPNFKG SKKILLLTET SRVEKVLDRL IESNEVVGKL VAVSVLDKPD FQHDCLKVVA
EGEIVNFATH EVVDEVFINL PSEKYNIGEL VSQFETMGID VIVNLNAFDR SLACNKQIRE
MAGLNVVTFS TTFYKTSHVI AKRIIDIVGA LVGLILCGLV SIVLVPLIRK DGGSAIFAQT
RIGKNGRQFT FYKFRSMCVD AEAKKRELME QNTMQGGMFK VDDDPRITKI GCFIRKTSLD
ELPQFYNVLK GDMSLVGTRP PTVDEYEHYT PEQKRRLSFK PGITGLWQVS GRSEIKNFDE
VVKLDVAYID DWTIWKDIEI LLKTVKVVLM KDGAK
//
