ID Q4K0T5_STREE Unreviewed; 227 AA.
AC Q4K0T5;
DT 02-AUG-2005, integrated into UniProtKB/TrEMBL.
DT 02-AUG-2005, sequence version 1.
DT 24-JAN-2024, entry version 65.
DE RecName: Full=Tyrosine-protein kinase CpsD {ECO:0000256|ARBA:ARBA00019200};
DE EC=2.7.10.2 {ECO:0000256|ARBA:ARBA00011903};
GN Name=wze {ECO:0000313|EMBL:CAI33715.1};
GN ORFNames=SPC20_0007 {ECO:0000313|EMBL:CAI33715.1};
OS Streptococcus pneumoniae.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=1313 {ECO:0000313|EMBL:CAI33715.1};
RN [1] {ECO:0000313|EMBL:CAI33715.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=34365 {ECO:0000313|EMBL:CAI33715.1};
RX PubMed=16532061; DOI=10.1371/journal.pgen.0020031;
RA Bentley S.D., Aanensen D.M., Mavroidi A., Saunders D., Rabbinowitsch E.,
RA Collins M., Donohoe K., Harris D., Murphy L., Quail M.A., Samuel G.,
RA Skovsted I.C., Kaltoft M.S., Barrell B., Reeves P.R., Parkhill J.,
RA Spratt B.G.;
RT "Genetic analysis of the capsular biosynthetic locus from all 90
RT pneumococcal serotypes.";
RL PLoS Genet. 2:262-268(2006).
RN [2] {ECO:0000313|EMBL:AFN40461.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=5931-06 {ECO:0000313|EMBL:AFN40461.1}, and 6320
RC {ECO:0000313|EMBL:AFN40477.1};
RX PubMed=22736767; DOI=10.1074/jbc.M112.380451;
RA Calix J.J., Porambo R.J., Brady A.M., Larson T.R., Yother J.,
RA Abeygunwardana C., Nahm M.H.;
RT "Biochemical, Genetic, and Serological Characterization of Two Capsule
RT Subtypes among Streptococcus pneumoniae Serotype 20 Strains: DISCOVERY OF A
RT NEW PNEUMOCOCCAL SEROTYPE.";
RL J. Biol. Chem. 287:27885-27894(2012).
CC -!- FUNCTION: Involved in the regulation of capsular polysaccharide
CC biosynthesis. Autophosphorylation of CpsD attenuates its activity and
CC reduces the level of encapsulation. May be part of a complex that
CC directs the coordinated polymerization and export to the cell surface
CC of the capsular polysaccharide. {ECO:0000256|ARBA:ARBA00024964}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001149};
CC -!- PATHWAY: Capsule biogenesis; capsule polysaccharide biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005132}.
CC -!- SIMILARITY: Belongs to the CpsD/CapB family.
CC {ECO:0000256|ARBA:ARBA00007316}.
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DR EMBL; JQ653093; AFN40461.1; -; Genomic_DNA.
DR EMBL; JQ653094; AFN40477.1; -; Genomic_DNA.
DR EMBL; CR931679; CAI33715.1; -; Genomic_DNA.
DR RefSeq; WP_001142505.1; NZ_UHGO01000005.1.
DR UniPathway; UPA00934; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0045227; P:capsule polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05387; BY-kinase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR025669; AAA_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005702; Wzc-like_C.
DR NCBIfam; TIGR01007; eps_fam; 1.
DR PANTHER; PTHR32309; TYROSINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR32309:SF13; TYROSINE-PROTEIN KINASE ETK-RELATED; 1.
DR Pfam; PF13614; AAA_31; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Capsule biogenesis/degradation {ECO:0000256|ARBA:ARBA00022903};
KW Exopolysaccharide synthesis {ECO:0000256|ARBA:ARBA00023169};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:CAI33715.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CAI33715.1};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT DOMAIN 36..166
FT /note="AAA"
FT /evidence="ECO:0000259|Pfam:PF13614"
SQ SEQUENCE 227 AA; 24946 MW; 6BF2271975450859 CRC64;
MPTLEIAQKK LEFIKKAEEY YNALCTNIQL SGDKLKVISV TSVNPGEGKT TTSVNIARSF
ARAGYKTLLI DGDTRNSVIS GVFKSREKIT GLTEFLSGTA DLSHGLCDTN IENLFVIQSG
SVSPNPTALL QSKNFNDMIE TLRKYFDYII VDTAPIGIVI DAAIITQKCD ASILVTATGE
VNKRDVQKAK QQLEQTEKLF LGVILNKFDV QHEKYGSYGG YGNYGKK
//
