ID   Q4LD16_9INFB            Unreviewed;       746 AA.
AC   Q4LD16;
DT   02-AUG-2005, integrated into UniProtKB/TrEMBL.
DT   02-AUG-2005, sequence version 1.
DT   08-NOV-2023, entry version 62.
DE   RecName: Full=RNA-directed RNA polymerase catalytic subunit {ECO:0000256|ARBA:ARBA00020035, ECO:0000256|RuleBase:RU004330};
DE            EC=2.7.7.48 {ECO:0000256|ARBA:ARBA00012494, ECO:0000256|RuleBase:RU004330};
DE   Flags: Fragment;
GN   Name=PB1 {ECO:0000313|EMBL:CAG96509.1};
OS   Influenza B virus (B/Hong Kong/692/01).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Insthoviricetes; Articulavirales; Orthomyxoviridae; Betainfluenzavirus;
OC   Betainfluenzavirus influenzae; Influenza B virus.
OX   NCBI_TaxID=279337 {ECO:0000313|EMBL:CAG96509.1};
RN   [1] {ECO:0000313|EMBL:CAG96509.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=B/Hong Kong/692/01 {ECO:0000313|EMBL:CAG96509.1};
RA   Wright H.G., Gregory V., Lin Y., Bennett M., Hay A.J.;
RT   "Reassortment of surface and internal genes of Influenza B viruses.";
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.48; Evidence={ECO:0000256|RuleBase:RU004330};
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DR   EMBL; AJ781180; CAG96509.1; -; Genomic_RNA.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR   Gene3D; 6.10.140.720; -; 1.
DR   HAMAP; MF_04065; INFV_RDRP; 1.
DR   InterPro; IPR007099; RNA-dir_pol_NSvirus.
DR   InterPro; IPR001407; RNA_pol_PB1_influenza.
DR   Pfam; PF00602; Flu_PB1; 1.
DR   PIRSF; PIRSF000827; RdRPol_OMV; 1.
DR   PROSITE; PS50525; RDRP_SSRNA_NEG_SEG; 1.
PE   3: Inferred from homology;
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484,
KW   ECO:0000256|RuleBase:RU004330};
KW   Transferase {ECO:0000256|ARBA:ARBA00022695};
KW   Viral RNA replication {ECO:0000256|ARBA:ARBA00022953}.
FT   DOMAIN          280..476
FT                   /note="RdRp catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50525"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:CAG96509.1"
FT   NON_TER         746
FT                   /evidence="ECO:0000313|EMBL:CAG96509.1"
SQ   SEQUENCE   746 AA;  83537 MW;  6D825F68D6C56460 CRC64;
     FLFIDVPIQA AISTTFPYTG VPPYSHGTGT GHTIDTVIRT HEYSNKGKQY VSDITGCTMV
     DPTNGPLPED NEPSAYAQLD CVLEALDRMD EEHPGLFQAA SQNAMEALMV TTVDKLTQGR
     QTFDWTVCRN QPAATALNTT ITSFRLNDLN GADKGGLVPF CQDIIDSLDK PEMTFFSVKN
     IKKKLPAKNR KGFLIKRIPM KVKDRISRVE YIKRALSLNT MTKDAERGKL KRRAIATAGI
     QIRGFVLVVE NLAKNICENL EQSGLPVGGN EKKAKLSNAV AKMLSNCPPG GISMTVTGDN
     TKWNECLNPR IFLAMTERIT RDSPIWFRDF CSIAPVLFSN KIARLGKGFM ITSKTKRLKA
     QIPCPDLFSI PLERYNEETR AKLKRLKPFF NEEGTASLSP GMMMGMFNML STVLGVAALG
     IKNIGNKEYL WDGLQSSDDF ALFVNAKDEE TCMEGINDFY RTCKLLGINM SKKKSYCNET
     GMFEFTSMFY RDGFVSNFAM EIPSFGVAGV NESADMAIGM TIIKNNMINN GMGPATAQTA
     IQLFIADYRY TYKCHRGDSK VEGKRMKIIK ELWENTKGRD GLLVADGGPN IYNLRNLHIP
     EIVLKYSLMD PEYKGRLLHP QNPFVGHLSI EGIKEADITP AHGPVKKMDY DAVSGTHSWR
     TKRNRSILNT DQRNMILEEQ CYAKCCNLFE ACFNSASYRK PVGQHSMLEA MAHRLRMDAR
     LDYESGRMSK DDFEKAMAHL GEIGYI
//