ID Q4MZQ0_THEPA Unreviewed; 1249 AA.
AC Q4MZQ0;
DT 02-AUG-2005, integrated into UniProtKB/TrEMBL.
DT 02-AUG-2005, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=NFACT RNA-binding domain-containing protein {ECO:0008006|Google:ProtNLM};
GN OrderedLocusNames=TP03_0467 {ECO:0000313|EMBL:EAN31211.1};
OS Theileria parva (East coast fever infection agent).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC Theileriidae; Theileria.
OX NCBI_TaxID=5875 {ECO:0000313|EMBL:EAN31211.1, ECO:0000313|Proteomes:UP000001949};
RN [1] {ECO:0000313|EMBL:EAN31211.1, ECO:0000313|Proteomes:UP000001949}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Muguga {ECO:0000313|EMBL:EAN31211.1,
RC ECO:0000313|Proteomes:UP000001949};
RX PubMed=15994558; DOI=10.1126/science.1110439;
RA Gardner M.J., Bishop R., Shah T., de Villiers E.P., Carlton J.M., Hall N.,
RA Ren Q., Paulsen I.T., Pain A., Berriman M., Wilson R.J.M., Sato S.,
RA Ralph S.A., Mann D.J., Xiong Z., Shallom S.J., Weidman J., Jiang L.,
RA Lynn J., Weaver B., Shoaibi A., Domingo A.R., Wasawo D., Crabtree J.,
RA Wortman J.R., Haas B., Angiuoli S.V., Creasy T.H., Lu C., Suh B.,
RA Silva J.C., Utterback T.R., Feldblyum T.V., Pertea M., Allen J.,
RA Nierman W.C., Taracha E.L.N., Salzberg S.L., White O.R., Fitzhugh H.A.,
RA Morzaria S., Venter J.C., Fraser C.M., Nene V.;
RT "Genome sequence of Theileria parva, a bovine pathogen that transforms
RT lymphocytes.";
RL Science 309:134-137(2005).
CC -!- SIMILARITY: Belongs to the NEMF family.
CC {ECO:0000256|ARBA:ARBA00008318}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAN31211.1}.
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DR EMBL; AAGK01000005; EAN31211.1; -; Genomic_DNA.
DR RefSeq; XP_763494.1; XM_758401.1.
DR AlphaFoldDB; Q4MZQ0; -.
DR STRING; 5875.Q4MZQ0; -.
DR EnsemblProtists; EAN31211; EAN31211; TP03_0467.
DR GeneID; 3499997; -.
DR KEGG; tpv:TP03_0467; -.
DR VEuPathDB; PiroplasmaDB:TpMuguga_03g00467; -.
DR eggNOG; KOG2030; Eukaryota.
DR InParanoid; Q4MZQ0; -.
DR OMA; DICAMVH; -.
DR Proteomes; UP000001949; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0072344; P:rescue of stalled ribosome; IEA:UniProt.
DR Gene3D; 2.30.310.10; ibrinogen binding protein from staphylococcus aureus domain; 1.
DR InterPro; IPR021846; NFACT-C.
DR InterPro; IPR008532; NFACT_RNA-bd.
DR PANTHER; PTHR15239; NUCLEAR EXPORT MEDIATOR FACTOR NEMF; 1.
DR PANTHER; PTHR15239:SF6; RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF; 1.
DR Pfam; PF11923; NFACT-C; 1.
DR Pfam; PF05670; NFACT-R_1; 1.
DR Pfam; PF05833; NFACT_N; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000001949}.
FT DOMAIN 499..635
FT /note="NFACT RNA-binding"
FT /evidence="ECO:0000259|Pfam:PF05670"
FT DOMAIN 1158..1219
FT /note="NFACT protein C-terminal"
FT /evidence="ECO:0000259|Pfam:PF11923"
FT REGION 395..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 680..820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 857..937
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 969..1032
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1080..1137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 317..344
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 432..459
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 680..814
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 861..932
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 977..1003
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1004..1024
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1083..1137
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1249 AA; 142800 MW; 30A1869FDB4D35DF CRC64;
MAKERLNAVD VAVVVSNLKK LISNLTLVNI YDITNRIFIL KFSKNENKIY ILIEIGCRIH
ATQFLRSVDH LPSNFNAKLR KHLRNRRLRD ISQISQDRVI DFTFSSEEYA HHLIVQLFLP
GNIYLTDHEY KVLTVLRPQN TGDKFFKVGS NYVYDMEYNS WFEKLRRPLV EELIVGNKLT
DIIKNLFPSI HHSFIFSVLK LKLKNTKGDG VDPKDLDRVY NLEDLDTVYH YVECIRTYLS
ELLSGKDKIG GYLYKNQKGE MEDFGLFEQE NSEYFEDFND AVDAFFTKHE LAKQEKKTQD
KKPTKLNKIK IDQDKREQKL VEDIRKLDLE IKLLEENVDI AENCLNLTKA LIASGASWND
IYEQLQIQRK QNHPLVHYIK EINIPTQTLI FHNPISGSDQ LSQGGQSGKP GKSGTQSKLS
KDLTASVSLD YRLNSHQNLK KLYNERKRLE NKLERTKIGK EYALKKVTKS LKKQETKKTD
KNKRDVRISS VRKRFWFEKF YWFITSQGYL VLAGRDALQN ELLVKKYLTN GDLYFHADIH
GAASVILKTN SNSSSFNLTT GTTSDNTETT NTSPPYDMIK SVKESIDEAG NFAVCLSTAW
NEKFSVQSWW VYWHQVSKTP PTGEYVPQGS FVIRGKKNYL PPQKLEMGIT YLFQVHPFHS
LEPTNFQDTL DGEGTVDNVV DEEDVVDDED EEDVEDDEVD VEDDEVDEDD SDDEDTVEDD
GDEVTVEGSD DTIVDEEITP EDDQDDSEDL GDDEDEETSV EEEENENSED SLEEDDEDVS
DSAEDPESEE NTVEDVEDED TEGNTVEDVE DVEDVEDKSV RIGHAEMLEE YEANIQKRTR
GRLPTAHPLK SKLLKLKHQL QKLNLTKTSK SSKSSSTQIS TKSSKDMQPQ PTQQSEHVTN
VKPVTNVKPV TKVESVSKVE LDSNSASPES CDNVERKSVR ILEPEKLEHS EEAVRKIRSR
KLTAVNPKFP KFNDFIPLNS GDSSNSRTSS DVKSTTNSDT KLKPSENTKL KPSENTKLKP
ENTKLKPFEN TNVNVKLEMT QVKSRGSSRM MRFINQKVSK IKKKYAQDDE ETQELRRLLT
GSKKIQAKTQ KSQSTNQKSQ STNQKSQSSN QKSQSSNQKS QFTPNQVGKI SYGNSVSTGQ
SEKFKEIETI SDKELEYYMK QLSCLTKELK EDDDVINVIP MCAPFSAIKH YKNALKLVPG
NAKKGTIATQ SLQHFIKNDP ERAHYLKLIT TDQLTLTLIG NCKFTNSKI
//
