ID Q4Q259_LEIMA Unreviewed; 845 AA.
AC Q4Q259;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 138.
DE SubName: Full=Elongation factor 2 {ECO:0000313|EMBL:CAJ08970.1};
GN Name=EF2-2 {ECO:0000313|EMBL:CAJ08970.1};
GN Synonyms=EF2-1 {ECO:0000313|EMBL:CAJ08969.1};
GN ORFNames=LMJF_36_0180 {ECO:0000313|EMBL:CAJ08969.1}, LMJF_36_0190
GN {ECO:0000313|EMBL:CAJ08970.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ08970.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ08970.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Friedlin {ECO:0000313|EMBL:CAJ08970.1}, and MHOM/IL/81/Friedlin
RC {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ08970.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Friedlin {ECO:0000313|EMBL:CAJ08970.1}, and MHOM/IL/81/Friedlin
RC {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
RN [3] {ECO:0000313|EMBL:CAJ08970.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Friedlin {ECO:0000313|EMBL:CAJ08970.1};
RA Aslett M.;
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FR796432; CAJ08969.1; -; Genomic_DNA.
DR EMBL; FR796432; CAJ08970.1; -; Genomic_DNA.
DR RefSeq; XP_001686588.1; XM_001686536.1.
DR RefSeq; XP_001686589.1; XM_001686537.1.
DR AlphaFoldDB; Q4Q259; -.
DR STRING; 5664.Q4Q259; -.
DR EnsemblProtists; CAJ08969; CAJ08969; LMJF_36_0180.
DR EnsemblProtists; CAJ08970; CAJ08970; LMJF_36_0190.
DR GeneID; 5655266; -.
DR GeneID; 5655267; -.
DR KEGG; lma:LMJF_36_0180; -.
DR KEGG; lma:LMJF_36_0190; -.
DR VEuPathDB; TriTrypDB:LmjF.36.0180; -.
DR VEuPathDB; TriTrypDB:LMJFC_360007900; -.
DR VEuPathDB; TriTrypDB:LMJLV39_360007100; -.
DR VEuPathDB; TriTrypDB:LMJSD75_360007000; -.
DR eggNOG; KOG0469; Eukaryota.
DR HOGENOM; CLU_002794_11_2_1; -.
DR InParanoid; Q4Q259; -.
DR OMA; NRHNRFY; -.
DR Proteomes; UP000000542; Chromosome 36.
DR GO; GO:0097014; C:ciliary plasm; ISO:GeneDB.
DR GO; GO:0005737; C:cytoplasm; ISO:GeneDB.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0043022; F:ribosome binding; IBA:GO_Central.
DR GO; GO:0003746; F:translation elongation factor activity; IBA:GO_Central.
DR GO; GO:0006414; P:translational elongation; IBA:GO_Central.
DR CDD; cd01681; aeEF2_snRNP_like_IV; 1.
DR CDD; cd04096; eEF2_snRNP_like_C; 1.
DR CDD; cd01885; EF2; 1.
DR CDD; cd16268; EF2_II; 1.
DR CDD; cd16261; EF2_snRNP_III; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.240; -; 1.
DR Gene3D; 3.30.70.870; Elongation Factor G (Translational Gtpase), domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR041095; EFG_II.
DR InterPro; IPR035647; EFG_III/V.
DR InterPro; IPR000640; EFG_V-like.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR42908:SF10; ELONGATION FACTOR 2; 1.
DR PANTHER; PTHR42908; TRANSLATION ELONGATION FACTOR-RELATED; 1.
DR Pfam; PF00679; EFG_C; 1.
DR Pfam; PF14492; EFG_III; 1.
DR Pfam; PF03764; EFG_IV; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SMART; SM00838; EFG_C; 1.
DR SMART; SM00889; EFG_IV; 1.
DR SUPFAM; SSF54980; EF-G C-terminal domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Elongation factor {ECO:0000313|EMBL:CAJ08970.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000313|EMBL:CAJ08970.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000542}.
FT DOMAIN 17..344
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 845 AA; 94133 MW; 6B3DDE076B080817 CRC64;
MVNFTVDQVR ELMDYPDQIR NMSVIAHVDH GKSTLSDSLV GAAGIIKMEE AGDKRIMDTR
ADEIARGITI KSTAISMHYH VPKEMIGDLD DDKRDFLINL IDSPGHVDFS SEVTAALRVT
DGALVVVDCV EGVCVQTETV LRQALTERIR PVVFINKVDR AILELQLDPE EAYQGFVKTL
QNVNVVVATY NDPSMGDVQV SPEKGTVAIG SGLQAWAFSL TRFANMYAAK FGVDELKMRE
RLWGDNFFDA KNKKWIKQET NADGERVRRA FCQFCLDPIY QIFDAVMNEK KDKVDKMLKS
LHVTLTAEER EQVPKKLLKT VMMKFLPAAE TLLQMIVAHL PSPKKAQAYR AEMLYSGEAS
PEDKYFMGIK NCDPAAPLML YISKMVPTAD RGRFFAFGRI FSGKVRSGQK VRIMGNNYVY
GKKQDLYEDK PVQRSVLMMG RYQEAVEDMP CGNVVGLVGV DKYIVKSATI TDDGESPHPL
RDMKYSVSPV VRVAVEAKNP SDLPKLVEGL KRLAKSDPLV VCSIEESGEH IVAGAGELHL
EICLKDLQED FMNGAPLKIS EPVVSFRETV TDVSSQQCLS KSANKHNRLF CRGAPLTEEL
ALAMEEGTAG PEADPKVRAR FLADNYEWDV QEARKIWCYG PDNRGPNVVV DVTKGVQNMA
EMKDSFVAAW QWATREGVLC DENMRGVRVN VEDVTMHADA IHRGGGQIIP TARRVFYACC
LTASPRLMEP MFVVDIQTVE HAMGGIYGVL TRRRGVIIGE ENRPGTPIYN VRAYLPVAES
FGFTADLRAG TGGQAFPQCV FDHWQEYPGD PLEPKSLANT TTLGIRTRKG LKPDIPGLDQ
FMDKL
//
