ID Q4Q2X5_LEIMA Unreviewed; 1931 AA.
AC Q4Q2X5;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:CAJ07938.1};
GN ORFNames=LMJF_34_2250 {ECO:0000313|EMBL:CAJ07938.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ07938.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ07938.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ07938.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796430; CAJ07938.1; -; Genomic_DNA.
DR RefSeq; XP_001686323.1; XM_001686271.1.
DR STRING; 5664.Q4Q2X5; -.
DR EnsemblProtists; CAJ07938; CAJ07938; LMJF_34_2250.
DR GeneID; 5654992; -.
DR KEGG; lma:LMJF_34_2250; -.
DR VEuPathDB; TriTrypDB:LmjF.34.2250; -.
DR VEuPathDB; TriTrypDB:LMJFC_340030900; -.
DR VEuPathDB; TriTrypDB:LMJLV39_340027200; -.
DR VEuPathDB; TriTrypDB:LMJSD75_340028100; -.
DR eggNOG; KOG0379; Eukaryota.
DR HOGENOM; CLU_235198_0_0_1; -.
DR InParanoid; Q4Q2X5; -.
DR OMA; MKGSAPG; -.
DR Proteomes; UP000000542; Chromosome 34.
DR GO; GO:0035869; C:ciliary transition zone; ISO:GeneDB.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 2.
DR InterPro; IPR011043; Gal_Oxase/kelch_b-propeller.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR PANTHER; PTHR23244; KELCH REPEAT DOMAIN; 1.
DR PANTHER; PTHR23244:SF471; KELCH REPEAT-CONTAINING PROTEIN 1-RELATED; 1.
DR Pfam; PF13418; Kelch_4; 1.
DR SUPFAM; SSF50965; Galactose oxidase, central domain; 1.
DR SUPFAM; SSF117281; Kelch motif; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000542}.
FT REGION 61..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 449..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 640..670
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 961..1008
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1053..1081
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1198..1236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1248..1305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1345..1371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1451..1493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1516..1538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1716..1741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..82
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 456..470
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1057..1076
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1248..1281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1350..1371
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1476..1493
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1931 AA; 205044 MW; 5BD1284765D4267B CRC64;
MSSASPPLPQ RGDAVQVQLV NADGSTIAQR PIHIEELLQQ KDHTVDIGAG IALRLEALNA
EQDYSDDNDT SAPDDSADDE EETKGSAEGA GARDESAAAA APPPGTQATM DWYDVLDALR
REQLDVKRNA AEVEDTMRKS GEGEGRLVTR HFNESRSAAT PLKWFSKATG LEGKAVAADD
AARSLPPPGA SRREVWASLA PAKNNTHPPN YKVLRYVSYM PVLEYRRFRP TALAFHAAAS
YLSRKDFGQR LLVYGGVSFG ARTVEQELYE FSILTGNWRR VEGRQLVPAG HYGHTMTVVE
SFDRLVVVGG IGPGGAAVSK EKRQAWVTDP LRAPRYRCLC PLLHCRAGQA ATALARADRT
AAPLPLSVSH VSVGFVSLLF DMNLSDQTWR AIQPATQFPL VYHTTVHFGK ELFVFGGLTD
DLRVSGQLLA INSATYAVRR IKTSAGSSSR FRQGVAPDDE AGEMHSGSDL DEGEAAGPGP
RFLHTAVRYG PYMIVYGGYD AQNEVLGDCW AFDMANERWE QLRCRGEAAG RAGHDCCVVG
CRMLVTGGFE SSLDEAGKAA SPVTTVMELN LVPTVHGEHI WRAEVRAHPP LPPLAFTRCA
PCGDDHSFLL FGGLTKRARH PSQSRSVGKR FASAKRHAAA SAAEESGADD AVDSDVDVDS
RPASHKVSER GASLAARHGL WKRLAPFDDG LVLTFPEKRR RSKGAKDEPV VNARGIEVAA
DELPEHLKAF VRRQEDFVRK KDAAAAETIR KTTLEEQEEM EPALYLTDAE IELLLHRSEE
CCVAFAERYK MNTLPSNVPD REERVHLIEE CISKSRQIRD VMRSMKGSAP GVTAVKSKTH
RKRAGQKFED YSAAKPFRRV VVMHLLESIK QHLSRMHRLN KALLTVDWPE KEGFLEAVDD
MQNSVHAVSR AINGVLNKYI QHRVESLMKG VDKHKEVMRL LTQVVEKNLH DKIWGIEAAR
DEKRQKHQRA RAAVAAPGQP AAAARSGSSS PAARRGRSAR SRSLGGGYHA DESKAVVCMM
DREWHGLLNR ARMVEKCAGH LRRYCEEGAA TSDTAPLSAL PPPPAPPPPR PSVEGPLSLP
LAPQQAPSLM MQVQPSLQAP TLAPGGLMAP PVLLPASVPL AGLLTSEAPE VPPVAAPAST
AGEAGAARPR EIMIQRSNEL RMTTATVAEE VRKAALDFHA ALAQAAAALP SASSAHASSA
TTTVSHPTAA PPRTTVGADI VAPTTPTPQL PVPAVMSSHT TTAAAIPGPT LAFQSSPSGA
SSSSSSGSSR SSSSSGSSGP AAATVMRGPS LQLPPGGSLP FATAAPPEST GFVRLQQPVT
ASVGLSTEAP LANVQQPQLI LAATSSHDAA PGASRGSRNP KTTSAAPAQA STVQGHAVSL
SVLRPILAAK ESLQQLQDKV TLIRLNEWDV SDLAGAPQDV KVEKLYRRLS KLLTGVAQCV
TATFLAKAGA RPPRLRPTSV SVGPPPQRPR SKKSTGEART SGAATKRASQ SKSLTSVAEA
RAISASAVFS QTLFSGAGGD KGDPSREGRG AAVGALPGAA DGNVGDTLRL MPLPPPVHNQ
VDDADDGWLS KRSRPTYGEA AGVPLVSHEA LLRDVRPAVV PTAAAFTSAA GPSAVEVHAV
YPDARTVPNA SATSLLCGSV APPAIAAGPW APAVSSVQRS GTAPVVALSV VPKVVMPAGA
NDVSTDEAGA AYMTQSPRRR RRSTIADLTQ LRHLSQNRLH DGSFGDGTAS SGDGIDPVTR
EPVTNITRGN FVVNADYLSR VAPHALLAAT TAEIELQGGA GGMQQAWSDI DEDYFYFGRP
VGKRATAAET VVSGPPYISN RPRGGVGVSP PVGTVMGSPR VNAELAASPI RGIPGVIPAS
TALRTRSSTA RGSSSGRRVS DHYLSSTASQ LLKLHTARPV VLKSGSKHSF FTPGELHLMQ
ARERLRSKSS M
//
