ID Q4Q636_LEIMA Unreviewed; 380 AA.
AC Q4Q636;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 24-JAN-2024, entry version 90.
DE SubName: Full=Putative 3,2-trans-enoyl-CoA isomerase,mitochondrial {ECO:0000313|EMBL:CAJ08414.1};
DE EC=5.3.3.8 {ECO:0000313|EMBL:CAJ08414.1};
GN ORFNames=LMJF_31_2250 {ECO:0000313|EMBL:CAJ08414.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ08414.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ08414.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ08414.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC {ECO:0000256|ARBA:ARBA00005254, ECO:0000256|RuleBase:RU003707}.
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DR EMBL; FR796427; CAJ08414.1; -; Genomic_DNA.
DR RefSeq; XP_001685212.1; XM_001685160.1.
DR AlphaFoldDB; Q4Q636; -.
DR STRING; 5664.Q4Q636; -.
DR EnsemblProtists; CAJ08414; CAJ08414; LMJF_31_2250.
DR GeneID; 5654157; -.
DR KEGG; lma:LMJF_31_2250; -.
DR VEuPathDB; TriTrypDB:LmjF.31.2250; -.
DR VEuPathDB; TriTrypDB:LMJFC_310037000; -.
DR VEuPathDB; TriTrypDB:LMJLV39_310031800; -.
DR VEuPathDB; TriTrypDB:LMJSD75_310031800; -.
DR eggNOG; KOG1683; Eukaryota.
DR HOGENOM; CLU_009834_7_5_1; -.
DR InParanoid; Q4Q636; -.
DR OMA; DIMEMYQ; -.
DR Proteomes; UP000000542; Chromosome 31.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0004165; F:delta(3)-delta(2)-enoyl-CoA isomerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IBA:GO_Central.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 6.10.250.170; -; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR PANTHER; PTHR11941; ENOYL-COA HYDRATASE-RELATED; 1.
DR PANTHER; PTHR11941:SF156; ISOMERASE, MITOCHONDRIAL, PUTATIVE-RELATED; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000313|EMBL:CAJ08414.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000542}.
FT REGION 68..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..102
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 380 AA; 42876 MW; 3D7DA5DC8D7B531C CRC64;
MKSSLRRRVR QASNEDPPYP TFLSHRLFVC CRRSTSAIMR RVISSSLTRG AGTLGVMSGL
FQLTQYRFQS QPPPGVPQGR HQDLNAAHAG SKHSDDAQPE FVPPKKPTEV PKLVRINTNE
KGITNVQLAR APVNSMSLEL FQELNQWMLW LGSNEETKAV IISSAIPTVF SAGLDLVEVH
NPKPDRVAVF WQSFQEMWLI LNSFPKPIIA AITGNSPAAG CIIAMGCDYR VMARGPKGNT
NNNRLYRIGL NETKLGLVAP PWVMPAYAYL LGSRQAERML QLGETPVADD ARNLGLIDEV
AADEERAIEV AYQQAERFLS VPQQSRWMAR DMMRREYLQM LASDEERNYD TEFFTQFVQS
PEVQKNLESY LERLKSCSRK
//
