ID Q4Q6T7_LEIMA Unreviewed; 370 AA.
AC Q4Q6T7;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE RecName: Full=SP-RING-type domain-containing protein {ECO:0000259|PROSITE:PS51044};
GN ORFNames=LMJF_30_3490 {ECO:0000313|EMBL:CAJ06856.1}, LMJF_30_3510
GN {ECO:0000313|EMBL:CAJ06860.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ06860.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ06860.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Friedlin {ECO:0000313|EMBL:CAJ06860.1}, and MHOM/IL/81/Friedlin
RC {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ06860.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Friedlin {ECO:0000313|EMBL:CAJ06860.1}, and MHOM/IL/81/Friedlin
RC {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
RN [3] {ECO:0000313|EMBL:CAJ06860.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Friedlin {ECO:0000313|EMBL:CAJ06860.1};
RA Aslett M.;
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FR796426; CAJ06856.1; -; Genomic_DNA.
DR EMBL; FR796426; CAJ06860.1; -; Genomic_DNA.
DR RefSeq; XP_001684959.1; XM_001684907.1.
DR RefSeq; XP_001684961.1; XM_001684909.1.
DR AlphaFoldDB; Q4Q6T7; -.
DR STRING; 5664.Q4Q6T7; -.
DR EnsemblProtists; CAJ06856; CAJ06856; LMJF_30_3490.
DR EnsemblProtists; CAJ06860; CAJ06860; LMJF_30_3510.
DR GeneID; 5653900; -.
DR GeneID; 5653902; -.
DR KEGG; lma:LMJF_30_3490; -.
DR KEGG; lma:LMJF_30_3510; -.
DR VEuPathDB; TriTrypDB:LmjF.30.3490; -.
DR VEuPathDB; TriTrypDB:LMJFC_300047400; -.
DR VEuPathDB; TriTrypDB:LMJLV39_300043900; -.
DR VEuPathDB; TriTrypDB:LMJSD75_300043000; -.
DR eggNOG; KOG2169; Eukaryota.
DR HOGENOM; CLU_748975_0_0_1; -.
DR InParanoid; Q4Q6T7; -.
DR OMA; IQCARQN; -.
DR Proteomes; UP000000542; Chromosome 30.
DR GO; GO:0061665; F:SUMO ligase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016925; P:protein sumoylation; IBA:GO_Central.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR004181; Znf_MIZ.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR10782:SF101; SP-RING-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR10782; ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF02891; zf-MIZ; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51044; ZF_SP_RING; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000000542};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00452}.
FT DOMAIN 248..329
FT /note="SP-RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51044"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 370 AA; 40992 MW; 80B8E59FDCA6D609 CRC64;
MHALSEALPA ARSAAKRTSG RSSSLLSAGD GEGGDASEED EDALPFVRAA RRHVLEVLRH
EVFENPSRFV LSPVYHFMDM LGAVVVENSN LTTTLPAPHT LHERPAEGFS PQRRVLLVPL
TEAYEHTTGW MVPTEMEGAQ LAMSLYVNDT PVSLPPNWQL SPAKEAAAVK TAMAVDITPL
VLSIERDLFS LQVIFSGDVA EMEMWRGVIA CVLVEEVELA QLGERIVSTY HKRRAPVIRR
SPLSSCGERG VVAITEVSVK IQCPITTLTM EIPVRGMYCE HLQCMELAAV LIQCARQNVW
NCPLCSAAMK PEDIIVNHRL KDWIASHSRE VVAQVEYIVE TELGRPLKIV YKAARPEQHS
TIEVIDDEEK
//
